A5102014711- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Neurotransmitter Receptor Influence on Behavior
- Neuroendocrine regulation and behavior
- Photoreceptor and optogenetics research
- Treatment of Major Depression
- Mental Health and Psychiatry
- Congenital heart defects research
- Tryptophan and brain disorders
- Health, Environment, Cognitive Aging
- Neuropeptides and Animal Physiology
- Health and Medical Research Impacts
- Mental Health Treatment and Access
- Retinal Development and Disorders
- Attention Deficit Hyperactivity Disorder
- Maternal Mental Health During Pregnancy and Postpartum
- Genetics and Neurodevelopmental Disorders
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Schizophrenia research and treatment
New York State Psychiatric Institute
2011-2025
Columbia University Irving Medical Center
2016-2025
National Institute of Neurological Disorders and Stroke
2018-2024
National Institutes of Health
2010-2024
Columbia University
2010-2024
National Institute of Mental Health
2016-2024
Office of the Director
2022-2023
Government of the United States of America
2023
National Institute on Minority Health and Health Disparities
2022
University at Buffalo, State University of New York
2020
An activity-dependent form of synaptic plasticity underlies the fine tuning connections in developing primary visual cortex mammals such as cat and monkey. Studies effects manipulations experience during a critical period have demonstrated that correlation-based competitive process governs this plasticity. The cellular mechanisms underlying competition, however, are poorly understood. Transgenic gene-targeting technologies led to development new category reagents potential help answer...
Although cortico-striato-thalamo-cortical (CSTC) circuit dysregulation is correlated with obsessive compulsive disorder (OCD), causation cannot be tested in humans. We used optogenetics mice to simulate CSTC hyperactivation observed OCD patients. Whereas acute orbitofrontal cortex (OFC)-ventromedial striatum (VMS) stimulation did not produce repetitive behaviors, repeated over multiple days generated a progressive increase grooming, mouse behavior related OCD. Increased grooming persisted...
Despite the increasing use of optogenetics in vivo, effects direct light exposure to brain tissue are understudied. Of particular concern is potential for heat induced by prolonged optical stimulation. We demonstrate that high-intensity light, delivered through an fiber, capable elevating firing rate locally, even absence opsin expression. Predicting severity and spatial extent any temperature increase during optogenetic stimulation therefore considerable importance. Here, we describe a...
Cross-frequency coupling supports the organization of brain rhythms and is present during a range cognitive functions. However, little known about whether how long-range cross-frequency across distant regions subserves working memory. Here we report that theta-slow gamma between hippocampus medial prefrontal cortex (mPFC) augmented in genetic mouse model dysfunction. This increased observed specifically when mice successfully perform spatial memory task. In wild-type mice, increasing task...
The US Centers for Disease Control and Prevention reported a decrease in the 2019 suicide rate, from 14.2 per 100 000 individuals 2018 to 13.9 2019, representing 833 fewer suicides.1 This is first national year-over-year since 1999, but efforts need consider trends among subgroups. Growing concerns regarding increasing rates of suicides Black youth2 led us examine subgroup over past 2 decades.
In 2013, a few years after the launch of National Institute Mental Health's Research Domain Criteria (RDoC) initiative, Cuthbert and Insel published paper titled "Toward future psychiatric diagnosis: seven pillars RDoC." The RDoC project is translational research effort to encourage new ways studying psychopathology through focus on disruptions in normal functions (such as reward learning or attention) that are defined jointly by observable behavior neurobiological measures. outlined...