A5101449593- Maternal Mental Health During Pregnancy and Postpartum
- Birth, Development, and Health
- Adolescent and Pediatric Healthcare
- Autism Spectrum Disorder Research
- Tryptophan and brain disorders
- Child and Adolescent Psychosocial and Emotional Development
- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Memory Processes and Influences
- Child Nutrition and Feeding Issues
- Family and Disability Support Research
- Infant Development and Preterm Care
- Breastfeeding Practices and Influences
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Folate and B Vitamins Research
- Attention Deficit Hyperactivity Disorder
- Genetics and Neurodevelopmental Disorders
- Health, Environment, Cognitive Aging
- Pregnancy and preeclampsia studies
- Smoking Behavior and Cessation
- Diet and metabolism studies
- Vitamin D Research Studies
- Face Recognition and Perception
- Influenza Virus Research Studies
Columbia University
2016-2025
Columbia University Irving Medical Center
2014-2024
New York Psychoanalytic Society and Institute
2008-2024
New York State Psychiatric Institute
2013-2022
Johns Hopkins University Applied Physics Laboratory
2022
Syngenta (United Kingdom)
2022
University of Turku
2013-2018
Finnish Institute for Health and Welfare
2018
Turku University Hospital
2014-2017
University of Oulu
2016-2017
Some, but not all, previous studies suggest that prenatal influenza exposure increases the risk of schizophrenia. These used dates epidemics and maternal recall infection to define exposure, suggesting discrepant findings may have resulted from misclassification.To examine whether serologically documented schizophrenia.Nested case-control study a large birth cohort, born 1959 through 1966, followed up for psychiatric disorders 30 38 years later.Population-based cohort.Cases were 64 cohort...
Accumulating evidence suggests that prenatal exposure to infection contributes the etiology of schizophrenia. This line investigation has been advanced by birth cohort studies utilize prospectively acquired data from serologic assays for infectious and immune biomarkers. These investigations have provided further support this hypothesis permitted new pathogens in relation schizophrenia risk. Prenatal infections associated with include rubella, influenza, toxoplasmosis. Maternal cytokines,...
OBJECTIVE: The authors examined the relationship between maternal antibody to toxoplasmosis and risk of schizophrenia other spectrum disorders in offspring. Toxoplasmosis is known adversely affect fetal brain development. METHOD: In a nested case-control design large birth cohort born 1959 1967, conducted serological assays for Toxoplasma on serum specimens from pregnancies giving rise 63 cases 123 matched comparison subjects. immunoglobulin (Ig)G was quantified by using Sabin-Feldman dye...
OBJECTIVE: Many studies have implicated prenatal infection in the etiology of schizophrenia. Cytokines, a family soluble polypeptides, are critically important immune response to and other inflammatory processes. The goal this study was determine whether second-trimester levels four cytokines—interleukin-8 (IL-8), interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)—are higher mothers offspring who later developed schizophrenia spectrum disorders than matched...
Immigrant groups in Western Europe have markedly increased rates of schizophrenia. The highest are found ethnic that predominantly black. Separating minority race/ethnicity from immigration is difficult; the US, these issues can be examined separately. Here we compared schizophrenia between whites and African Americans evaluated whether association was mediated by socioeconomic status (SES) family origin a US birth cohort.Study subjects were offspring women enrolled during pregnancy at...
Gestational influenza has been associated previously with schizophrenia in offspring, but the relationship between this exposure and bipolar disorder (BD) is unclear. The identification of gestational as a risk factor for BD may have potential preventive approaches.To test hypothesis that maternal during pregnancy related to among offspring.Nested case-control study population-based birth cohort from Child Health Development Study (CHDS). From January 1, 1959, through December 31, 1966, CHDS...
Maternal inflammation level during pregnancy was related to risk of schizophrenia in offspring, adding new evidence for the association infection and immune activation with development disorder.
Converging evidence suggests that a neurodevelopmental disruption plays role in the vulnerability to schizophrenia. The authors review supporting utero exposure nutritional deficiency as determinant of We first describe studies demonstrating early gestational Dutch Hunger Winter 1944--1945 and severe famine China are each associated with an increased risk schizophrenia offspring. plausibility several candidate micronutrients potential factors for biological mechanisms may underlie these...
We sought to examine the relationship between maternal exposure adult respiratory infections and schizophrenia spectrum disorder (SSD) in Prenatal Determinants of Schizophrenia (PDS) Study, a large birth cohort investigation. Previous work suggests that second trimester infection may be risk factor for SSD. therefore examined whether this class was associated with For purpose, we capitalized on several design advantages PDS including comprehensive, prospective data base physician-diagnosed...
Background Prenatal and perinatal factors have been linked to affective disorders. We therefore undertook an exploratory study determine whether prenatal exposure severe famine was associated with increased risk of Method Monthly birth cohorts that were exposed unexposed the Dutch Hunger Winter 1944–45 identified. The cumulative incidences psychoses neurotic depression (ICD–9 criteria) compared between during each trimester gestation. Results relative (RR) psychosis (broad restricted...
Objective: In this birth cohort study, the authors examined relation between prenatal exposure to maternal genital/reproductive (G/R) infections and schizophrenia in offspring. Method: The consisted of 7,794 offspring pregnancies with prospectively acquired data on G/R from obstetric records. diagnosed 71 cases other spectrum disorders cohort. relationship risk was modeled. Results: Exposure during periconceptional period associated a significantly increased disorders, adjustment for race,...