A5038234207- Maternal Mental Health During Pregnancy and Postpartum
- Pregnancy and Medication Impact
- Child and Adolescent Psychosocial and Emotional Development
- Cardiovascular Issues in Pregnancy
- Pregnancy and preeclampsia studies
- Pharmacological Effects and Toxicity Studies
- Birth, Development, and Health
- Breastfeeding Practices and Influences
- Autism Spectrum Disorder Research
- Pharmaceutical studies and practices
- Prenatal Substance Exposure Effects
- Child and Adolescent Health
- Infant Development and Preterm Care
- Folate and B Vitamins Research
- Prenatal Screening and Diagnostics
- Research in Social Sciences
- Electrolyte and hormonal disorders
- Genetics and Neurodevelopmental Disorders
- Schizophrenia research and treatment
- Reproductive System and Pregnancy
- Assisted Reproductive Technology and Twin Pregnancy
- Maternal and Perinatal Health Interventions
- Thyroid Disorders and Treatments
- Reproductive Health and Contraception
- Vitamin D Research Studies
University of Helsinki
2012-2024
Helsinki University Hospital
2014-2024
University of Turku
2012-2024
Columbia University Irving Medical Center
2017
Columbia University
2013-2016
Turku University Hospital
2015-2016
Nordic School of Public Health
2011-2015
Hospital District of Helsinki and Uusimaa
2011-2015
Norwegian Institute of Public Health
2015
University of Bergen
2015
In Brief OBJECTIVE: To study the effects of selective serotonin reuptake inhibitors (SSRIs) on pregnancy outcome. METHODS: We performed a population-based women exposed to SSRIs during (n = 1782). Data were derived from national project in Finland, established by 3 governmental organizations. that project, Drug Reimbursement Register, Medical Birth Register Congenital Malformations, and Induced Abortions have been linked. Comparisons made between with SSRI purchases matched controls...
To estimate the risk of major congenital anomalies after exposure to selective serotonin reuptake inhibitors during pregnancy.A retrospective cohort study based on national population-based registers (years 1996-2006) births, anomalies, and terminations pregnancy because severe fetal (maintained by National Institute for Health Welfare, source offspring population n=635,583) drug reimbursements (Social Insurance Institution) linked a personal identification number. Offspring exposed first...
In 2005-2006, several studies noted an increased risk of cardiovascular birth defects associated with maternal use paroxetine compared other antidepressants in the same class. this study, authors sought to determine whether was infants women exposed drug during first trimester pregnancy.From teratology information services around world, collected prospectively ascertained, unpublished cases early pregnancy and them unexposed cohort. The also contacted published database on as a class how...
Abstract BACKGROUND Azathioprine (AZP) interferes with nucleic acid synthesis and is teratogenic in animals. In view of the paucity information on use AZP during pregnancy we investigated this subject a prospective, controlled, multicenter study. Our objective was too determine whether exposure to increases risk for major malformations effect outcome. METHODS Pregnant women who contacted one seven teratogen services were compared cohort pregnant two took nonteratogenic treatments their...
Objective High‐dose methotrexate (MTX) exposure during pregnancy is associated with embryopathy. The teratogenic potential of MTX at dosages typically used in the treatment rheumatic diseases remains uncertain. aim this study was to evaluate risk spontaneous abortion, major birth defects, elective termination pregnancy, shortened gestational age delivery, and reduced weight women exposed MTX. Methods Pregnancy outcome taking (≤30 mg/week) either after conception or within 12 weeks before...
<b>Objective</b> To assess whether use of specific selective serotonin reuptake inhibitors (SSRIs) or venlafaxine in early pregnancy is associated with an increased risk birth defects, emphasis on cardiovascular defects even when accounting for lifestyle other familial confounding. <b>Design</b> Multicountry population based cohort study, including sibling controlled design. <b>Setting</b> Nordic (Denmark, Finland, Iceland, Norway, and Sweden) identified from nationwide health registers at...
Aims TNF‐α inhibitors are considered relatively safe in pregnancy but experience is still limited. The aim of this study was to evaluate the risk major birth defects, spontaneous abortion, preterm and reduced weight after first trimester exposure inhibitors. Methods Pregnancy outcomes women on adalimumab, infliximab, etanercept, certolizumab pegol or golimumab were evaluated a prospective observational cohort compared with non‐exposed random sample. samples drawn from pregnancies identified...
Speech/language, scholastic, and motor disorders are common in children. It is unknown whether exposure to selective serotonin reuptake inhibitors (SSRIs) during pregnancy influences susceptibility these disorders.To examine SSRI associated with speech/language, offspring up early adolescence.This prospective birth cohort study examined national population-based register data Finland from 1996 2010. The sampling frame includes 845 345 pregnant women their singleton on maternal use of...
Objective: Using national register data, the authors examined relationship between prenatal selective serotonin reuptake inhibitor (SSRI) treatment and pregnancy complications, accounting for psychiatric diagnoses related to SSRI use. Method: This was a population-based prospective birth cohort study using data. The sampling frame included 845,345 offspring, representing all singleton live births in Finland 1996 2010. Pregnancies were classified as exposed SSRIs (N=15,729), unexposed but...
Summary Background : Proton pump inhibitors are used to treat gastro‐oesophageal reflux and peptic ulcers. Gastro‐oesophageal is a common condition in pregnancy. Human pregnancy experience with lansoprazole or pantoprazole very limited. More data exist on the safety of omeprazole Aim To assess proton Methods The rate major anomalies was compared between pregnant women exposed omeprazole, lanzoprazole, control group counselled for non‐teratogens. study design multicentre ( n = 8),...
A pattern of major and minor congenital anomalies, facial dysmorphic features, neurodevelopmental difficulties, including cognitive social impairments has been reported in some children exposed to sodium valproate (VPA) during pregnancy. Recognition the increased risks utero exposure VPA for malformations, effects particular, taken many years but these are now acknowledged following publication outcomes several prospective studies registries. As with other teratogens, can have variable...
Concerns have been raised about the use of topical retinoids since publication isolated cases characteristic retinoid embryopathy, originally described after oral use. A collaborative study European Network Teratology Information Services was carried out to evaluate rate congenital malformations following first-trimester exposure. population 235 exposed pregnant women compared with 444 controls. No significant differences were observed between groups regard rates spontaneous abortion (odds...
The aim of this population-based nationwide drugs and pregnancy surveillance system was to get basic information on the use prescribed during achieve more detailed drug exposure-outcome associations with data obtained from Finnish national health registers.The are based all pregnancies ending in births (n = 632,629) or termination (TOP) 117,255) Finland between 1996 2006. containing maternal background factors, chronic diseases purchases pregnancy, born children, induced abortions, perinatal...
This multicenter, observational prospective cohort study addresses the risk associated with exposure to mirtazapine during pregnancy. Pregnancy outcomes after were compared 2 matched control groups: (1) any selective serotonin reuptake inhibitor (SSRI, subjects a psychiatric condition) and (2) no medication known be teratogenic or antidepressant (general subjects). Data collected by members of European Network Teratology Information Services between 1995 2011. Observations from 357 exposed...
Abstract Purpose To study if second-generation antipsychotic (S-GA) use during pregnancy is associated with an increased risk of and neonatal complications. Methods A population-based birth cohort using national register data extracted from the “Drugs Pregnancy” database in Finland, years 1996–2016. The sampling frame included 1,181,090 pregnant women their singleton births. Women were categorized into three groups: exposed to S-GAs ( n = 4225), first-generation antipsychotics (F-GAs) 1576),...
To study if second-generation antipsychotic (S-GA) use during the first trimester of pregnancy is associated with an increased risk major congenital malformations (MCM).A population-based birth cohort using national register data extracted from Drugs and Pregnancy database in Finland, years 1996-2017. The sampling frame included 1,273,987 pregnant women. We singleton pregnancies ending live or stillbirth termination due to severe malformation. Pregnancies exposure known teratogens were...
BACKGROUND: Loperamide is a synthetic piperidine derivative used for the treatment of both acute and chronic diarrhea. Little known about its safety risk in pregnancy. Human data are limited to one surveillance study Michigan Medicaid patients, with 108 women exposed first trimester. In this there were six major birth defects, three which cardiovascular anomalies. OBJECTIVES: To determine whether loperamide use pregnancy associated an increased malformations. The secondary end points rates...