A5033274421- Advanced Neuroimaging Techniques and Applications
- Pharmacological Effects and Toxicity Studies
- Neonatal and fetal brain pathology
- Functional Brain Connectivity Studies
- Fetal and Pediatric Neurological Disorders
- Epilepsy research and treatment
- Pregnancy and Medication Impact
- Maternal Mental Health During Pregnancy and Postpartum
- Child and Adolescent Psychosocial and Emotional Development
- Atrial Fibrillation Management and Outcomes
- COVID-19 and Mental Health
- Traumatic Brain Injury Research
- COVID-19 Clinical Research Studies
- Neuroendocrine regulation and behavior
- Cardiac Arrhythmias and Treatments
- Memory and Neural Mechanisms
- Dementia and Cognitive Impairment Research
- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced MRI Techniques and Applications
- Health disparities and outcomes
- Evolutionary Psychology and Human Behavior
- Hemispheric Asymmetry in Neuroscience
- Intensive Care Unit Cognitive Disorders
- Long-Term Effects of COVID-19
Aston University
2017-2024
Deakin University
2019-2024
Murdoch Children's Research Institute
2014-2024
Mid Cheshire Hospitals NHS Foundation Trust
2024
NHS Lothian
2024
University of Ottawa
2024
University of Calgary
2024
University of Birmingham
2010-2023
Newcastle upon Tyne Hospitals NHS Foundation Trust
2019-2023
Great North Children's Hospital
2019-2023
Plasticity is an intrinsic property of the central nervous system, reflecting its capacity to respond in a dynamic manner environment and experience via modification neural circuitry. In context healthy development, plasticity considered beneficial, facilitating adaptive change response environmental stimuli enrichment, with research documenting establishment new connections mapping between activity behaviour. Less known about impact this young, injured brain. This review seeks explore...
Type 2 diabetes (T2DM) is associated with brain atrophy and cerebrovascular disease. We aimed to define the regional distribution of in T2DM examine whether or lesions are feasible links between cognitive function.This cross-sectional study used magnetic resonance imaging (MRI) scans tests 350 participants 363 without T2DM. With voxel-based morphometry, we studied measured (infarcts, microbleeds, white matter hyperintensity [WMH] volume) (gray matter, hippocampal volumes) while blinded...
Gait impairments are associated with falls and loss of independence. The study factors poorer gait may assist in developing methods to preserve mobility older people. aim this was examine the associations between a range cognitive functions variability population-based sample intra-individual measures were obtained using GAITRite walkway people, aged 60–85 years (N = 422), randomly selected from Tasmanian electoral roll. Raw scores battery subjected principal component analyses deriving four...
Abstract The neuropeptide oxytocin (OXT) plays an important role in complex socio-affective behaviours such as affiliation, attachment, stress and anxiety. Previous studies have focused on the amygdala target of OXT's effects. However, effects OXT connectivity with cortical regions medial frontal cortex, mediator social cognition emotion regulation, remain unexplored. In a randomized, double-blind, cross-over design, 15 volunteers received intranasal or placebo prior to resting-state...
Generalized social anxiety disorder (GSAD) is associated with heightened limbic and prefrontal activation to negative cues conveying threat (e.g. fearful faces), but less known about brain response non-threatening stimuli. The neuropeptide oxytocin (Oxt) has been shown attenuate (and normalize) fear-related reactivity emotionally cues. Here, we examined the effects of intranasal Oxt on cortical sad faces in patients GSAD matched controls (Con). In a double-blind placebo-controlled...
To examine the impact of COVID-19 restrictions among children with attention-deficit/hyperactivity disorder (ADHD).Parents 213 Australian (5-17 years) ADHD completed a survey in May 2020 when were place (i.e., requiring citizens to stay at home except for essential reasons).Compared pre-pandemic, had less exercise (Odds Ratio (OR) = 0.4; 95% CI 0.3-0.6), outdoor time (OR and enjoyment activities 6.5; 4.0-10.4), while television 4.0; 2.5-6.5), social media 2.4; 1.3-4.5), gaming 2.0; 1.3-3.0),...
Summary Purpose The association between autism spectrum disorders ( ASD s) and prenatal anticonvulsant exposure is increasingly investigated, but comprehensive, blinded assessment using a validated instrument for within well‐characterized prospective cohort has not been conducted. Thus, existing studies may represent an underestimate of the true risk. Herein we present study in children exposed to anticonvulsants during pregnancy, with all assessments conducted by examiners who were...
<b><i>Objective:</i></b> To describe a protocol for use in young children and adolescents determining language representation. <b><i>Methods:</i></b> We performed 130 fMRI studies 48 17 adults. Verb generation (VG) orthographic lexical retrieval (OLR) were used. The localization lateralization of activation was rated visually. Regional voxel counts measured asymmetry extent activation. <b><i>Results:</i></b> Activation predominantly left-lateralized (children 85%, adults 94%), there no...
Fetal exposure to some antiepileptic drugs (AEDs) carries increased risk of major birth defects, and may be associated with reduced intellectual abilities. The impact on language remains unclear. This study aimed investigate the fetal AED skills.Women epilepsy their children were recruited this observational through Australian Pregnancy Register for Women Epilepsy Allied Disorders. Language skills 102 AED-exposed assessed using Clinical Evaluation Fundamentals, fourth edition (CELF-4)....
Niemann-Pick disease type C (NPC) is a progressive neurovisceral disorder with disrupted intracellular cholesterol metabolism that results in significant alterations to neuronal and axonal structure. Adult patients present ataxia, gaze palsy, impaired cognition, neuropsychiatric illness, but the neural substrate has not been well-characterized vivo. Our aim was investigate sample of adults confirmed NPC for gray white matter abnormalities.We utilized combination optimized voxel-based...
Prenatal exposure to sodium valproate (VPA) and polytherapy has been linked with increased risk of birth defects cognitive impairment in young children. We evaluated the impact prenatal VPA school-aged Fifty-seven children exposed (n = 23), 15), or without 19) were assessed using Wechsler Intelligence Scale for Children--Fourth Edition. Information on maternal epilepsy, pregnancy, medical history was obtained prospectively through Australian Pregnancy Register Women Epilepsy Allied...
Gait slowing and cognitive decline are both common in older people. Although cross-sectionally related, the longitudinal associations between specific functions gait speed less well understood. We aimed to determine whether domains associated with change speed. Participants aged 60–85, randomly selected from electoral roll, were assessed twice over 3 years. was obtained using GAITRite walkway. Raw scores a battery subjected principal component analyses deriving summary of executive function,...
There is a poor understanding of the interplay between cognitive and physiological functions in leading to falls. We hypothesized that poorer function would modify effect on increased risk falling older people.A range (executive function/attention, memory, processing speed, visuospatial ability) (vision, proprioception, sway, leg strength, reaction time) were measured using standardized tests 386 randomly selected adults aged 60-86. Incident falls recorded over 12 months. Log-multinomial...
The COVID-19 pandemic presents significant risks to the mental health and wellbeing of families. This study aimed examine: (1) patterns parent child (0–18 years) health, substance use, couple conflict, parenting practices, family functioning during compared pre-pandemic data; (2) associations between parent, child, outcomes both pre-existing risk factors stressors. Participants were Australian mothers (81%) fathers aged 18 years over who parents a 0–18 (N=2,365). Parents completed an online...
Portraits, both photographic and painted, are often produced with more of one side the face showing than other. Typically, left is overrepresented, head turned slightly to sitter's right. This leftward bias weaker for painted male portraits non-existent scientists from Royal Society. What mechanism might account this bias? Examination by left- right-handers self-portraits suggests that not determined a mechanical preference artist or viewer's aesthetics. The seems be sitters their desire...
The shape of the corpus callosum may differ in schizophrenia, although no study has compared first-episode with established illness.To investigate size and a large sample people schizophrenia.Callosal were determined using high-resolution magnetic resonance imaging on 76 patients schizophrenia-spectrum disorders, 86 schizophrenia 55 healthy participants.There significant differences total area across groups. Reductions callosal width seen region anterior genu disorder (P<0.005). Similar...