A5054400319- Balance, Gait, and Falls Prevention
- Cerebral Palsy and Movement Disorders
- Stroke Rehabilitation and Recovery
- Dementia and Cognitive Impairment Research
- Geriatric Care and Nursing Homes
- Physical Activity and Health
- Diet and metabolism studies
- Advanced Neuroimaging Techniques and Applications
- Frailty in Older Adults
- Acute Ischemic Stroke Management
- Osteoarthritis Treatment and Mechanisms
- Occupational Therapy Practice and Research
- Nutrition and Health in Aging
- Musculoskeletal pain and rehabilitation
- Obesity, Physical Activity, Diet
- Chronic Disease Management Strategies
- Health disparities and outcomes
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Telemedicine and Telehealth Implementation
- Injury Epidemiology and Prevention
- Intracranial Aneurysms: Treatment and Complications
- Neurological Disease Mechanisms and Treatments
- Total Knee Arthroplasty Outcomes
- Nutritional Studies and Diet
University of Tasmania
2016-2025
Monash University
2016-2025
National Ageing Research Institute
2022-2024
Peninsula Health
2016-2024
Menzies School of Health Research
2008-2024
Menzies Institute for Medical Research
2015-2024
Australian Regenerative Medicine Institute
2014-2024
Monash Health
2013-2022
Murdoch Children's Research Institute
2015-2022
Cabrini Hospital
2022
<h3>Objectives:</h3> Our objective is to report prevalence of motoric cognitive risk syndrome (MCR), a newly described predementia characterized by slow gait and complaints, in multiple countries, its association with dementia risk. <h3>Methods:</h3> Pooled MCR analysis individual data from 26,802 adults without disability aged 60 years older 22 cohorts 17 countries. We also examined incident impairment (Mini-Mental State Examination decline ≥4 points) associated 4,812 individuals baseline...
Background: gait variability may be an important predictor of falls risk, but its characteristics are poorly understood.
it is uncertain as to which measures of gait best predict those who are likely fall. Our aim was investigate the associations and variability with incident falls risk.individuals aged 60-86 years (n = 412) were randomly selected from Tasmanian electoral roll. Average collected on a computerised walkway. Falls recorded prospectively over 12 months. Log multinomial regression used estimate relative risk single multiple associated measures. Covariates included age, sex, sensorimotor cognitive...
<h3>Objective:</h3> Our objective was to investigate whether type 2 diabetes mellitus (T2DM) influences neurodegeneration in a manner similar Alzheimer disease (AD), by promoting brain β-amyloid (Aβ) or tau. <h3>Methods:</h3> We studied the cross-sectional associations of T2DM with cortical thickness, Aβ load, and CSF levels tau sample people from Alzheimer9s Disease Neuroimaging Initiative diagnoses AD dementia, mild cognitive impairment, normal cognition. All (n = 816) received MRI,...
<h3>Importance</h3> Dual decline in gait speed and cognition has been found to be associated with increased dementia risk previous studies. However, it is unclear if risks are conferred by a domain-specific gait. <h3>Objective</h3> To examine associations between dual (ie, global, memory, processing speed, verbal fluency) of dementia. <h3>Design, Setting, Participants</h3> This cohort study used data from older adults Australia the US who participated randomized clinical trial testing...
Background and Purpose— The association between cerebral white matter lesions (WMLs) the risk of falls in older people is uncertain, with no supporting prospective evidence. We aimed to determine incident associated WML volume, interactions gait, other sensorimotor factors leading falls. Methods— conducted a prospective, population-based study (n=294, mean age 72.3 years, independently mobile). Volumetric MRI, computerized gait measures, measures were obtained at baseline. Incident recorded...
Gait impairments are associated with falls and loss of independence. The study factors poorer gait may assist in developing methods to preserve mobility older people. aim this was examine the associations between a range cognitive functions variability population-based sample intra-individual measures were obtained using GAITRite walkway people, aged 60–85 years (N = 422), randomly selected from Tasmanian electoral roll. Raw scores battery subjected principal component analyses deriving four...
Objectives To investigate longitudinal associations between changes in brain structure and gait decline. Design Longitudinal. Setting Population‐based Tasmanian Study of Cognition Gait. Participants Two hundred twenty‐five individuals aged 60 to 86 (mean age 71.4 ± 6.8) randomly selected from the electoral roll with baseline follow‐up data. Measurements Volumes gray matter, white hippocampi, matter lesions ( WML ) were estimated using automated segmentation magnetic resonance imaging MRI )....
Background. Gait disorders, a highly prevalent condition in older adults, are associated with several adverse health consequences. analysis allows qualitative and quantitative assessments of gait that improves the understanding mechanisms disorders choice interventions. This manuscript aims 1) to give consensus guidance for clinical spatiotemporal based on recorded footfalls adults aged 65 years over, 2) provide reference values parameters healthy free cognitive impairment multi-morbidities....
Background. Adequate mobility is essential to maintain an independent and active lifestyle. The aim of this cross-sectional study examine the associations age with temporal spatial gait variables in a population-based sample older people, whether these are modified by sex.
To study longitudinal relationships between type 2 diabetes mellitus (T2DM), cortical thickness, and cognitive function in older people with normal cognition, mild impairment, Alzheimer disease (AD).The sample was derived from the Alzheimer's Disease Neuroimaging Initiative cohort who underwent brain MRI tests annually for 5 years. Presence of T2DM based on fasting blood glucose ≥7.0mml/L or use glucose-lowering agents. We used latent growth curve modeling to explore T2DM, function,...
Background and purpose The differences in gait abnormalities from the earliest to later stages of dementia different subtypes have not been fully examined. This study aims compare spatiotemporal parameters cognitively healthy individuals, patients with amnestic mild cognitive impairment ( MCI ) non‐amnestic , moderate Alzheimer's disease AD non‐Alzheimer's (non‐ ). Methods Based on a cross‐sectional design, 1719 participants (77.4 ± 7.3 years, 53.9% female) were recruited cohorts seven...
Purpose: To compare the performance of low muscle mass and function with falls risk, incident fracture mortality over 10 years.
Background: The Motoric Cognitive Risk Syndrome (MCR) is characterized by slow gait speed and cognitive complaints. Objectives: objective of this study was to determine if the presence MCR increases risk falls in older people. Methods: Individual participant data (n = 6,204) from five longitudinal studies three countries were used for analysis. diagnosis defined as both objectively measured subjective complaints those without dementia or mobility disability. Falls prospectively ascertained...
Background: the study of factors associated with age-related gait decline may assist in developing methods to preserve mobility older people.
Gait slowing and cognitive decline are both common in older people. Although cross-sectionally related, the longitudinal associations between specific functions gait speed less well understood. We aimed to determine whether domains associated with change speed. Participants aged 60–85, randomly selected from electoral roll, were assessed twice over 3 years. was obtained using GAITRite walkway. Raw scores a battery subjected principal component analyses deriving summary of executive function,...
There is a poor understanding of the interplay between cognitive and physiological functions in leading to falls. We hypothesized that poorer function would modify effect on increased risk falling older people.A range (executive function/attention, memory, processing speed, visuospatial ability) (vision, proprioception, sway, leg strength, reaction time) were measured using standardized tests 386 randomly selected adults aged 60-86. Incident falls recorded over 12 months. Log-multinomial...
Background and Purpose— Although cerebral white matter lesions (WMLs), silent infarcts (SIs), microbleeds (MBs) are individually associated with poorer gait balance, it is unknown if they interact. We studied the interactions of WML volume SI MB on postural stability. Methods— Participants in a population-based study aged 60 to 86 years underwent brain MRI, computerized measurement, physiological profile assessment Segmentation procedures standard rating methods were used measure WML, SI,...
Background Waist circumference (WC) is an indicator of intra-abdominal adipose tissue, high levels which confer increased risk cardiometabolic disease. Population data on WC should be more informative than body mass index (BMI), a general size. This study aimed to evaluate the importance relative BMI in cross-sectional relationships with blood pressure (BP), glucose, and total cholesterol (TC) adult population Vietnam. Methods The were collected population-based survey conducted during...