A5026751971- Osteoarthritis Treatment and Mechanisms
- Bone health and osteoporosis research
- Vitamin D Research Studies
- Nutrition and Health in Aging
- Total Knee Arthroplasty Outcomes
- Rheumatoid Arthritis Research and Therapies
- Hip and Femur Fractures
- Knee injuries and reconstruction techniques
- Musculoskeletal pain and rehabilitation
- Lower Extremity Biomechanics and Pathologies
- Physical Activity and Health
- Bone and Joint Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Body Composition Measurement Techniques
- Obesity, Physical Activity, Diet
- Health Systems, Economic Evaluations, Quality of Life
- Nutritional Studies and Diet
- Hip disorders and treatments
- Primary Care and Health Outcomes
- Bone health and treatments
- Diabetic Foot Ulcer Assessment and Management
- Birth, Development, and Health
- Balance, Gait, and Falls Prevention
- Sports injuries and prevention
- Musculoskeletal synovial abnormalities and treatments
University of Tasmania
2015-2024
Menzies School of Health Research
2014-2023
Menzies Institute for Medical Research
2015-2023
Zhujiang Hospital
2020
Southern Medical University
2020
Anhui Medical University
2020
Third Affiliated Hospital of Sun Yat-sen University
2020
Sun Yat-sen University
2020
Australian Regenerative Medicine Institute
2020
Monash University
2013-2020
To compare the effect of a single infusion zoledronic acid (ZA) with placebo on knee pain and bone marrow lesions (BMLs).Adults aged 50-80 years (n=59) clinical osteoarthritis BMLs were randomised to receive either ZA (5 mg/100 ml) or placebo. determined using proton density-weighted fat saturation MR images at baseline, 6 12 months. Pain function measured visual analogue scale (VAS) injury outcome score (KOOS) scale.At mean VAS was 54 mm total BML area 468 mm(2). scores significantly...
<h3>Importance</h3> Observational studies suggest that vitamin D supplementation is associated with benefits for knee osteoarthritis, but current trial evidence contradictory. <h3>Objective</h3> To compare the effects of vs placebo on pain and cartilage volume in patients symptomatic osteoarthritis low levels. <h3>Design, Setting, Participants</h3> A multicenter randomized, double-blind, placebo-controlled clinical Tasmania Victoria, Australia. Participants 25-hydroxyvitamin (12.5-60 nmol/L)...
Summary Objective Low 25‐hydroxyvitamin D (25OHD) levels may be associated with both sarcopenia (the age‐related decline in muscle mass and function) low physical activity (PA). Our objective was to describe prospective associations between 25OHD, parameters, PA community‐dwelling older adults. Design Prospective, population‐based study a mean follow‐up of 2·6 ± 0·4 years. Patients Six hundred eighty‐six adults (49% women; SD 62 7 years old). Measurements Appendicular lean percentage (%ALM)...
The Cochrane Musculoskeletal Group (CMSG), one of 53 groups the not-for-profit, international Collaboration, prepares, maintains, and disseminates systematic reviews treatments for musculoskeletal diseases. It is important that authors conducting CMSG readers our be aware use updated, state-of-the-art review methodology. One hundred sixty have been published. Previous method guidelines interventions in field published 2006 substantially updated to incorporate methodological advances are...
ABSTRACT Osteoporosis and osteopenia are increasingly prevalent conditions among older adults. Not only do the fractures associated with poor bone health have significant consequences for individual, but also their economic impact is placing increasing financial burden on governments society. This study aimed to determine direct cost of osteoporosis, osteopenia, Australians aged 50 years in 2017. uses previous Australian data incidence prevalence osteoporosis together recent service...
Abstract Introduction The aim of this study was to describe the relationship between accelerometer‐determined physical activity (PA), muscle mass, and lower‐limb strength in community‐dwelling older adults. Methods Six hundred thirty‐six adults (66 ± 7 years) were studied. Muscle mass measured using dual‐energy x‐ray absorptiometry, whilst lower limb via dynamometry. We minutes/day spent sedentary, light, moderate, vigorous intensity Actigraph GT1M accelerometers. Results Participants a...
Purpose: To compare the performance of low muscle mass and function with falls risk, incident fracture mortality over 10 years.
<h3>Importance</h3> A proof-of-principle study suggested that intravenous zoledronic acid may reduce knee pain and the size of bone marrow lesions in people with osteoarthritis, but data from large trials are lacking. <h3>Objective</h3> To determine effects on cartilage volume loss patients symptomatic osteoarthritis lesions. <h3>Design, Setting, Participants</h3> 24-month multicenter, double-blind placebo-controlled randomized clinical trial conducted at 4 sites Australia (1 research center...
Background: Current pharmacologic therapies for patients with osteoarthritis are suboptimal. Objective: To determine the efficacy of Curcuma longa extract (CL) reducing knee symptoms and effusion–synovitis in symptomatic effusion–synovitis. Design: Randomized, double-blind, placebo-controlled trial. (Australian New Zealand Clinical Trials Registry: ACTRN12618000080224) Setting: Single-center study from southern Tasmania, Australia. Participants: 70 participants ultrasonography-defined...
Abstract Background To describe demographic and clinical factors associated with the presence incidence of depression explore temporal relationship between joint symptoms in patients symptomatic knee osteoarthritis (OA). Methods Three hundred ninety-seven participants were selected from a randomized controlled trial people OA vitamin D deficiency (age 63.3 ± 7.1 year, 48.6% female). Depression severity assessed using patient health questionnaire (PHQ-9) Western Ontario McMaster Universities...
Osteoporosis knowledge is an important contributor to improving exercise and calcium intake behaviour. However, there are few validated instruments for measuring osteoporosis levels. The aim of this study was design a valid reliable instrument measure in Australian women. A 20 item with true, false don't know responses drafted, based on the Australia Prevention Self-management course information leaflet "Understanding Osteoporosis". scoring range 1 20. This administered 467...
There are conflicting data on the natural history and clinical significance of bone marrow lesions (BMLs). The aims this study were to describe MRI-detected BMLs at knee using a quantitative measure examine association with pain, function stiffness scores, total replacement (TKR) surgery. A 395 older males females randomly selected from general population (mean age 63 years, range 52 79) measured baseline approximately 2.7 years later. determined T2-weighted fat saturation MRI by measuring...
Objectives This study describes the longitudinal association between objectively assessed physical activity (PA) and knee structural change measured using MRI. Methods 405 community-dwelling adults aged 51–81 years were at baseline approximately 2.7 later. MRI of right follow-up was performed to evaluate bone marrow lesions (BMLs), meniscal pathology, cartilage defects, volume. PA by pedometer (steps/day). Results Doing ≥10 000 steps/day associated with BML increases (RR 1.97, 95% CI 1.19...
Recent evidence suggests that bone marrow lesions (BMLs) play a pivotal role in knee osteoarthritis (OA). The aims of this study were to determine: 1) whether baseline BML presence and/or severity predict site-specific cartilage defect progression and volume loss; 2) defects progression. A total 405 subjects (mean age 63 years, range 52 79) measured at approximately 2.7 years later. Magnetic resonance imaging (MRI) the right was performed measure volume, (0 4), BMLs 3) medial tibial (MT),...