A5073470831- Bone health and osteoporosis research
- Hip and Femur Fractures
- Bone health and treatments
- Nutrition and Health in Aging
- Vitamin D Research Studies
- Bone fractures and treatments
- Body Composition Measurement Techniques
- Alkaline Phosphatase Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Bone Metabolism and Diseases
- Radiopharmaceutical Chemistry and Applications
- Hip disorders and treatments
- Acute Myeloid Leukemia Research
- Stress Responses and Cortisol
- Nursing Roles and Practices
- Climate Change and Health Impacts
- Artificial Intelligence in Healthcare and Education
- Genetic factors in colorectal cancer
- Nutritional Studies and Diet
- Medical Imaging and Analysis
- Cardiac Arrest and Resuscitation
- Hormonal and reproductive studies
- Cardiac Imaging and Diagnostics
- Adipokines, Inflammation, and Metabolic Diseases
- Genetic Associations and Epidemiology
Monash Health
2017-2024
Monash University
2017-2024
Hudson Institute of Medical Research
2023
The University of Melbourne
2014-2019
Western Health
2014-2019
Sunshine Hospital
2019
Objectives To examine whether combined vitamin D and calcium supplementation improves insulin sensitivity, secretion, β-cell function, inflammation metabolic markers. Design 6-month randomized, placebo-controlled trial. Participants Ninety-five adults with serum 25-hydroxyvitamin [25(OH)D] ≤55 nmol/L at risk of type 2 diabetes (with prediabetes or an AUSDRISK score ≥15) were randomized. Analyses included participants who completed the baseline final visits (treatment n = 35; placebo 45)....
ABSTRACT Osteoporosis and osteopenia are increasingly prevalent conditions among older adults. Not only do the fractures associated with poor bone health have significant consequences for individual, but also their economic impact is placing increasing financial burden on governments society. This study aimed to determine direct cost of osteoporosis, osteopenia, Australians aged 50 years in 2017. uses previous Australian data incidence prevalence osteoporosis together recent service...
We investigated change in health-related quality of life due to fracture Australian adults aged over 50 years. Fractures reduce with the loss sustained at least 12 months. At a population level, was equivalent 65 days full health per fracture. aimed quantify (HRQoL) that occurred as consequence using EQ-5D-3 L questionnaire. Adults ≥50 years low moderate energy were recruited from eight study centres across Australia. This prospective included an 18-month follow-up participants within 2...
Ageing, obesity and the metabolic syndrome (MetS) may all contribute to poor muscle health (sarcopenia). This study aimed determine cross-sectional associations between MetS (International Diabetes Federation classification) sarcopenia (revised European Working Group on Sarcopenia in Older People definition) 84 overweight obese older adults. Components of included strength (hand grip leg extension), physical performance (stair climb test short battery (SPPB), including gait speed repeated...
PURPOSE Suppression of ovarian function and aromatase inhibition (AI) increases disease-free survival in premenopausal women with estrogen receptor (ER)–positive early-stage breast cancer but accelerates bone loss. We therefore hypothesized that suppressing remodeling using denosumab (DMAB) would prevent loss these women. METHODS In a 12-month double-blind randomized trial, 68 ER-positive commencing suppression AI were randomly assigned to 60 mg DMAB (n = 34) or placebo (PBO; n once every 6...
Abstract Quantifying precision error for DXA, peripheral QCT (pQCT), and HR-pQCT is crucial monitoring longitudinal changes in body composition musculoskeletal outcomes. Agreement associations between bone variables assessed using pQCT second-generation are unclear. This study aimed to determine the of, agreement between, via pQCT, HR-pQCT. Thirty older adults (mean age: 64.2 ± 8.0 yr; women: 67%) were recruited. DXA scans performed at total hip, lumbar spine, whole body. Distal (4%)...
ABSTRACT Advancing age is accompanied by a reduction in bone formation and remodeling imbalance, which produces microstructural deterioration. This may be partly caused diversion of mesenchymal cells towards adipocytes rather than osteoblast lineage cells. We hypothesized that deterioration would associated with an increased marrow adiposity, each these traits independently nonvertebral fractures improve discrimination women from controls over achieved femoral neck (FN) areal mineral density...
Low vitamin D status commonly accompanies obesity, and both deficiency obesity have been associated with falls fracture risk in older adults. We aimed to determine the associations of serum 25-hydroxyvitamin (25(OH)D) concentrations physical performance bone health community-dwelling, overweight obese men women. Serum 25(OH)D were measured 84 participants body mass index ≥25 kg/m2 (mean ± SD age 62.4 7.9 years; 55% women). Physical function was determined by short battery, hand grip...
Abstract Objective In men, many effects of testosterone (T) on the skeleton are thought to be mediated by estradiol (E2), but trial evidence is largely lacking. This study aimed determine E2 bone health in men absence endogenous T. Design a 6-month randomized, placebo-controlled with hypothesis that would slow decline volumetric mineral density (vBMD) and microstructure, maintain areal (aBMD), reduce remodelling. Methods 78 participants receiving androgen deprivation therapy for prostate...
Despite well-defined criteria for radiographic diagnosis of atypical femur fractures (AFFs), missed and delayed is common. An AFF diagnostic software could provide timely detection to prevent progression incomplete or development contralateral AFFs. In this study, we investigated the ability an artificial intelligence (AI)-based application, using deep learning models (DLMs), particularly convolutional neural networks (CNNs), detect AFFs from femoral radiographs. A labelled Australian...
Summary Objectives To determine sex‐specific associations between insulin resistance and bone parameters measured by peripheral quantitative computed tomography in overweight obese community‐dwelling older adults. Study design Cross‐sectional study of 79 adults (mean ± SD age 62.8 7.9 years; body mass index 32.3 6.1 kg/m 2 ; 58% women). Main outcome measures Peripheral assessed distal radius tibia trabecular volumetric mineral density (vBMD) proximal cortical vBMD, periosteal circumference,...
This case describes a young man with an unusual cause of severe osteoporosis and markedly deranged bone microarchitecture resulting in multiple fractures. A potentially pathogenic germline variant the runt-related transcription factor 1 (RUNX1) gene was discovered by focused 51-gene myeloid malignancy panel during investigation for his unexplained normochromic normocytic anemia. Further bone-specific genetic testing pedigree analysis were declined patient. Recent experimental evidence...
Abstract Several small genetic association studies have been conducted for atypical femur fracture (AFF) without replication of results. We assessed previously implicated and novel genes associated with AFFs in a larger set unrelated AFF cases using whole exome sequencing (WES). performed gene-based analysis on 139 European 196 controls matched bisphosphonate use. tested all rare, protein-altering variants both candidate gene hypothesis-free approaches. In the latter, suggestively...
Aboriginal and Torres Strait Islander Australians have a substantially greater fracture risk, where men are 50% women 26% more likely to experience hip compared with non-Indigenous Australians. Fall-related injuries in this population also increased by 10%/year 4.3%/year This study aims determine why falls risk higher All clinical assessments will be performed at one centre Melbourne, Australia. At baseline, participants assessments, including questionnaires, anthropometry, bone structure,...
Based on the current paradigm, a healthy bone is one with adequate mass without microarchitectural decay. However, these two features may not be sufficient to ensure that healthy. In addition, components must correctly assembled and aligned. This ensures "the right amount of bone, at place" thus, an optimal cohesion or interplay between constituents. Disorganization independent contributor abnormalities including fragility fractures. Indeed, many diseases characterized by presence...