A5020458358- Pregnancy and Medication Impact
- Pharmacovigilance and Adverse Drug Reactions
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Forensic Toxicology and Drug Analysis
- Pharmaceutical studies and practices
- Cannabis and Cannabinoid Research
- Antibiotics Pharmacokinetics and Efficacy
- Electrolyte and hormonal disorders
- Drug-Induced Adverse Reactions
- Biosimilars and Bioanalytical Methods
- Reproductive System and Pregnancy
- Health, Medicine and Society
- Alcohol Consumption and Health Effects
- Pregnancy and preeclampsia studies
- Maternal Mental Health During Pregnancy and Postpartum
- Intramuscular injections and effects
- Complementary and Alternative Medicine Studies
- Multiple Sclerosis Research Studies
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Prenatal Substance Exposure Effects
- Healthcare Systems and Practices
- Breastfeeding Practices and Influences
- Acute Kidney Injury Research
University of Lausanne
2003-2025
University Hospital of Lausanne
2006-2024
Hôpital Orthopédique de la Suisse Romande
2020
Institute of Social and Preventive Medicine
2016
Informatica Tecnologie e Servizi (Italy)
2015
Newcastle upon Tyne Hospitals NHS Foundation Trust
2015
Newcastle University
2015
Collaborative Group (United States)
2010
Sanofi (Switzerland)
2005
Aims TNF‐α inhibitors are considered relatively safe in pregnancy but experience is still limited. The aim of this study was to evaluate the risk major birth defects, spontaneous abortion, preterm and reduced weight after first trimester exposure inhibitors. Methods Pregnancy outcomes women on adalimumab, infliximab, etanercept, certolizumab pegol or golimumab were evaluated a prospective observational cohort compared with non‐exposed random sample. samples drawn from pregnancies identified...
Abstract Complementary medicine (CM) is used by one third to half of cancer patients throughout the world. The objective this study was describe prevalence CM use and potential for interactions with treatments in an academic oncology centre. A cross-sectional conducted among undergoing current treatment. Among 132 included patients, 56% had since their diagnosis 45% were using during treatment at time survey. main green tea (35%), herbal homeopathy (27%), dietary supplements medicines (27%)....
To investigate pregnancy outcomes following maternal use of pregabalin.This multicenter, observational prospective cohort study compared in women exposed to pregabalin with those matched controls (not any medications known be teratogenic or antiepileptic drugs). Teratology Information Services systematically collected data between 2004 and 2013.Data were from 164 pregnancies 656 controls. A significantly higher major birth defect rate the group was observed after exclusion chromosomal...
To assess the effects of dronedarone on renal function and tubular cation handling.Twelve healthy males were enrolled in a randomized, cross-over, placebo-controlled, double-blind study. They received 400 mg or placebo twice daily for 7 days. Baseline on-treatment tests performed under strict standardization intakes, by assessing creatinine, sinistrin, para-amino-hippurate (PAH) N-methylnicotinamide (NMN) CLs, electrolyte excretion.Compared with placebo, significantly decreased creatinine CL...
Abstract Background Cannabis is the most commonly used illegal drug and its therapeutic aspects have a growing interest. Short-term psychotic reactions been described but not clearly with synthetic oral THC, especially in occasional users. Case presentations We report two cases of healthy subjects who were regular cannabis users without psychiatric history developed transient symptoms (depersonalization, paranoid feelings derealisation) following administration cannabis. In contrast to other...
Delta(9)-Tetrahydrocannabinol (THC) is frequently found in the blood of drivers suspected driving under influence cannabis or involved traffic crashes. The present study used a double-blind crossover design to compare effects medium (16.5 mg THC) and high doses (45.7 hemp milk decoctions dose dronabinol (20 synthetic THC, Marinol on several skills required for safe driving. Forensic interpretation cannabinoids concentrations were attempted using models proposed by Daldrup (cannabis...
Concerns have been raised about the use of topical retinoids since publication isolated cases characteristic retinoid embryopathy, originally described after oral use. A collaborative study European Network Teratology Information Services was carried out to evaluate rate congenital malformations following first-trimester exposure. population 235 exposed pregnant women compared with 444 controls. No significant differences were observed between groups regard rates spontaneous abortion (odds...
Aims Metformin is used to treat type 2 diabetes, polycystic ovary syndrome associated infertility, and gestational diabetes. This study aims evaluate the safety of metformin in early pregnancy. Method We evaluated risk major birth defects pregnancy losses a cohort pregnant women exposed during first trimester for different indications relative matched unexposed reference group. Results The was 5.1% (20/392) pregnancies 2.1% (9/431) group [adjusted odds ratio (OR) 1.70; 95% CI 0.70–4.38]....
Objective To gain medical insight into the clinical course and safety of otolaryngologic disorders following immunisation with severe acute respiratory coronavirus (SARS-CoV-2) mRNA-based vaccines.Design Case description.Study sample We report four cases transient audio-vestibular symptoms, which occurred shortly after inoculation two BNT162b2 (Pfizer-BioNTech®) mRNA-1273 (Moderna®) vaccines.Results Hearing loss was unilateral in all recovered at least partially: it associated persistent...
Abstract Background Model-informed precision dosing (MIPD) combines population pharmacokinetic knowledge with therapeutic drug monitoring (TDM) to optimize dosage adjustment. It could improve target concentration attainment over empirical TDM, still widely practised for broad-spectrum antibiotics. Objectives To evaluate the respective performance of TDM and MIPD in achieving piperacillin exposure. Methods Measurements from 80 courses intermittent infusions, each two samples, were...
This multicenter, observational prospective cohort study addresses the risk associated with exposure to mirtazapine during pregnancy. Pregnancy outcomes after were compared 2 matched control groups: (1) any selective serotonin reuptake inhibitor (SSRI, subjects a psychiatric condition) and (2) no medication known be teratogenic or antidepressant (general subjects). Data collected by members of European Network Teratology Information Services between 1995 2011. Observations from 357 exposed...
This prospective multicentre cohort study investigated pregnancy outcomes after fingolimod use for multiple sclerosis during pregnancy. Pregnancy of 63 and 62 interferon-β-exposed pregnancies were compared. Rates major congenital anomalies (MCA) 4.8% (2/42) in the group versus 2.3% (1/44) interferon-β (odds ratio, 2.2; 95% confidence interval, 0.2–24.6). The adjusted hazard ratio spontaneous abortion was 0.6 (95% 0.2–1.8). Further studies are needed to definitely rule out a moderately...
Introduction: Broad-spectrum beta-lactams are commonly prescribed for empirical or selective treatment of bacterial infections in children with malignancies. In the immunocompromised, appropriate concentration exposure is crucial to ensure antimicrobial efficacy. Augmented renal clearance (ARC) increasingly recognized this population, and raises concern unmet targets. We conducted a retrospective evaluation meropenem piperacillin our hospital's pediatric hematology-oncology patients....
Ivermectin has been used since the 1980s as an anthelmintic and antiectoparasite agent worldwide. Currently, only available oral formulation is tablets designed for adult patients. A patient-friendly orodispersible tablet pediatric use (CHILD-IVITAB) developed entering early phase clinical trials. To inform program of CHILD-IVITAB, 16 healthy adults were enrolled in a I, single-center, open-label, randomized, 2-period, crossover, single-dose trial which aimed to compare palatability,...
Abstract The initial Phase-I single centre, dose, randomized, double-blind, cross-over study was planned to assess the pharmacokinetic and pharmacodynamic bioequivalence of trastuzumab biosimilar (MYL-1401O) compared reference Herceptin ® . Their respective immunomodulation profile presented in this paper involved healthy males receiving a infusion both monoclonals, separated by washout period. Sixty parameters were assessed total, including serum cytokines, peripheral mononuclear cell...
Perampanel is one of the latest released antiepileptic drugs (AEDs). Early studies suggest no significant liver enzyme induction from this compound. We report on two patients with medically resistant epilepsy, who had perampanel added to their usual regimen. Both experienced a worsening epilepsy and presented in convulsive status epilepticus; concurrent drug levels (phenytoin, phenobarbital, rufinamide) were significantly decreased (<50%) comparison prior introduction. Intravenous load...