A5004390379- Pharmaceutical studies and practices
- Antibiotics Pharmacokinetics and Efficacy
- Pregnancy and Medication Impact
- Cannabis and Cannabinoid Research
- Epilepsy research and treatment
- Drug Transport and Resistance Mechanisms
- Pharmacological Effects and Toxicity Studies
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Acute Lymphoblastic Leukemia research
- Antibiotic Resistance in Bacteria
- Receptor Mechanisms and Signaling
- Pneumonia and Respiratory Infections
- Blood disorders and treatments
- Neonatal Respiratory Health Research
- Breastfeeding Practices and Influences
- Biosimilars and Bioanalytical Methods
- Forensic Toxicology and Drug Analysis
- Dialysis and Renal Disease Management
- Antimicrobial Resistance in Staphylococcus
- Child Nutrition and Feeding Issues
- Multiple Myeloma Research and Treatments
- Gestational Diabetes Research and Management
- Neuroscience of respiration and sleep
- Acute Kidney Injury Research
University Hospital of Lausanne
2012-2025
University of Lausanne
2012-2024
Civil Service
2019
Sarah Lawrence College
2017
Oregon Health & Science University
2010
Michigan State University
2010
Haverford College
2008
NACE International
1990
The dose-dependent toxicity of the main psychoactive component cannabis in brain regions rich cannabinoid CB1 receptors is well known animal studies. However, research humans does not show common findings across studies regarding that are affected after long-term exposure to cannabis. In present study, we investigate (using Voxel-based Morphometry) gray matter changes a group regular smokers comparison with occasional matched by years use. We provide evidence use associated volume reduction...
Objectives Glucagon-like peptide 1 receptor agonists (GLP1-RA) are indicated for the treatment of type 2 diabetes and more recently weight loss. The aim this study was to assess risks associated with GLP1-RA exposure during early pregnancy. Design This multicentre, observational prospective cohort compared pregnancy outcomes in women exposed either or obesity those two reference groups: (1) at least one non-GLP1-RA antidiabetic drug first trimester (2) a group overweight/obese without...
The 2023-2024 updates on teratovigilance, with a focus antiseizure medications, highlight several key points. American medical societies have revised their recommendations: maintaining effective seizure control is essential for both maternal and fetal health; lamotrigine, levetiracetam, oxcarbazepine are preferred first-line treatments, whereas valproic acid topiramate should be avoided if possible. In March 2024, an update indicated increased risk of neurodevelopmental disorders prenatal...
Objective To gain medical insight into the clinical course and safety of otolaryngologic disorders following immunisation with severe acute respiratory coronavirus (SARS-CoV-2) mRNA-based vaccines.Design Case description.Study sample We report four cases transient audio-vestibular symptoms, which occurred shortly after inoculation two BNT162b2 (Pfizer-BioNTech®) mRNA-1273 (Moderna®) vaccines.Results Hearing loss was unilateral in all recovered at least partially: it associated persistent...
Some forensic and clinical circumstances require knowledge of the frequency drug use. Care patient, administrative, legal consequences will be different if subject is a regular or an occasional cannabis smoker. To this end, 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THCCOOH) has been proposed as criterion to help distinguish between these two groups users. However, date indicator not adequately assessed under experimental conditions. We carried out controlled administration study smoked with...
Abstract Purpose/Background Trazodone is indicated for the treatment of major depressive disorder, but more frequently prescribed off-label at lower doses insomnia in women childbearing age. The aim this study was to assess risks linked trazodone exposure during pregnancy which limited safety data are available. Methods/Procedures This multicenter, observational prospective cohort compared outcomes exposed early against those a reference group selective serotonin reuptake inhibitors (SSRIs)...
Introduction: Broad-spectrum beta-lactams are commonly prescribed for empirical or selective treatment of bacterial infections in children with malignancies. In the immunocompromised, appropriate concentration exposure is crucial to ensure antimicrobial efficacy. Augmented renal clearance (ARC) increasingly recognized this population, and raises concern unmet targets. We conducted a retrospective evaluation meropenem piperacillin our hospital's pediatric hematology-oncology patients....
Abstract Background The activities of Rac1 and Cdc42 are essential for HRas-induced transformation rodent fibroblasts. What is more, expression constitutively activated mutants and/or sufficient their malignant transformation. role these two Rho GTPases in HRas-mediated human fibroblasts has not been studied. Here we evaluated the contribution to maintaining fibroblasts, determined ability or induce a fibroblast cell strain. Methods Under control tetracycline regulatable promoter, dominant...
Ivermectin has been used since the 1980s as an anthelmintic and antiectoparasite agent worldwide. Currently, only available oral formulation is tablets designed for adult patients. A patient-friendly orodispersible tablet pediatric use (CHILD-IVITAB) developed entering early phase clinical trials. To inform program of CHILD-IVITAB, 16 healthy adults were enrolled in a I, single-center, open-label, randomized, 2-period, crossover, single-dose trial which aimed to compare palatability,...
Abstract The initial Phase-I single centre, dose, randomized, double-blind, cross-over study was planned to assess the pharmacokinetic and pharmacodynamic bioequivalence of trastuzumab biosimilar (MYL-1401O) compared reference Herceptin ® . Their respective immunomodulation profile presented in this paper involved healthy males receiving a infusion both monoclonals, separated by washout period. Sixty parameters were assessed total, including serum cytokines, peripheral mononuclear cell...
Abstract Midazolam is commonly used to treat refractory seizures in newborns and as a first‐line anti‐epileptic drug children. Its use treatment of neonatal has not been investigated so far. We retrospectively studied the tolerability midazolam 72 newborn infants who received i.v. or i.n. for seizures. No major side‐effect exclusively due was reported. The route 20 patients (27.8%). Effectiveness could be formally evaluated absence systematic electroencephalogram recording while...
Abstract A pilot study was conducted aiming at specifying sultiame's pharmacokinetic profile, completed by in vitro assays evaluating the intraerythrocytic transfer of sultiame and a model assessing its distribution. Single oral doses (Ospolot ® 50, 100, 200 mg) were administered open‐label to four healthy volunteers. Serial plasma, whole blood, urine samples collected. spiking experiment also performed characterize exchanges between plasma erythrocytes vitro. Pharmacokinetic parameters...
Abstract We report the case of a drug interaction between methotrexate (MTX) and chloral hydrate (CH) observed in child treated for acute leukemia. Significantly slower MTX clearance increased exposure occurred on first three courses high‐dose chemotherapy when co‐administered with CH despite normal renal function, adequate hydration, alkalinization. Mean area under curve associated administration was 1,134 µmol hours/L, compared to 608 hours/L after discontinuation CH. This possibly...
The incidence of diabetes mellitus (both pregestational and gestational) is increasing worldwide, hyperglycemia during pregnancy associated with adverse outcomes. Evidence on the safety efficacy metformin has accumulated resulting in an increase its prescription many reports.
In this article, we reported the case of a child patient who was admitted to our PICU for severe acute respiratory distress syndrome (ARDS) while being treated with trimethoprim-sulfamethoxazole (TMP-SMX) osteomyelitis. Based on timing exposure, lack alternative explanations, and clinical course similar previously described cases, suspect that TMP-SMX may have triggered ARDS. Despite meeting criteria extracorporeal membrane oxygenation cannulation, conservative management lung recruitment...
Ethosuximide, the first-line therapy for childhood absence epilepsy, is currently formulated as a syrup (Zarontin®, Pfizer) with bitter taste and high sugar content, poorly adapted to children, ketogenic diet. The collaborative European FP7 project KIEKIDS aimed at developing an innovative sugar-free, tasteless formulation convenient pediatric use. This dual Phase-I study evaluated two granule formulations based on lipid multiparticulate (LMP) technology. Two panels of 6 healthy adult...
Imipenem is a broad-spectrum antibacterial agent used in critically ill neonates after failure of first-line treatments. Few studies have described imipenem disposition this population. The objectives our study were: (i) to characterize population pharmacokinetics (PK) cohort neonates; and (ii) conduct model-based simulations evaluate the performance six different dosing regimens aiming at optimizing PK target attainment.A total 173 plasma samples from 82 were collected over 15 years...
The antiparasitic drug ivermectin is approved for persons > 15 kg in the US and EU. A pharmacometric (PMX) population model with clinical PK data was developed (i) to characterize effect of patient-friendly formulation CHILD-IVITAB on absorption process (ii) evaluate dosing studies children < kg. Simulations were performed identify associated similar exposure coverage ≥ as observed adults receiving reference STROMECTOL®. total 448 concentrations available from 16 healthy adults. rate...
Background: A marker chromosome (MC) is a fragmented whose origin cannot be identified from an existing autosomal or sex chromosome. Recently, MC was found to result chromothripsis. Chromothripsis catastrophic phenomenon by which chromosomes are shattered into tens hundreds of fragments, and half the cases related TP53 gene mutation. relatively common abnormality its incidence in acute myeloid leukemia (AML) approximately 15%. Although AML with reported have poor prognosis after intensive...