A5010319058- Pregnancy and Medication Impact
- Maternal Mental Health During Pregnancy and Postpartum
- Pharmacological Effects and Toxicity Studies
- Electrolyte and hormonal disorders
- Epilepsy research and treatment
- Pregnancy and preeclampsia studies
- Cardiovascular Issues in Pregnancy
- Pharmaceutical studies and practices
- Breastfeeding Practices and Influences
- COVID-19 Impact on Reproduction
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Dental Anxiety and Anesthesia Techniques
- Global Maternal and Child Health
- Eosinophilic Esophagitis
- Prenatal Screening and Diagnostics
- Reproductive Health and Contraception
- Nausea and vomiting management
- Reproductive System and Pregnancy
- Child Nutrition and Feeding Issues
- Ethics in Clinical Research
- Bariatric Surgery and Outcomes
- Demographic Trends and Gender Preferences
- Sexual function and dysfunction studies
- Research on Leishmaniasis Studies
Israel Ministry of Health
2015-2025
Royal Hospital for Women
2014
Hebrew University of Jerusalem
2002-2008
Recent studies have suggested a possible association between maternal use of selective serotonin reuptake inhibitors (SSRIs) in early pregnancy and cardiovascular anomalies. The aim the present study was to evaluate teratogenic risk paroxetine fluoxetine.
Objective High‐dose methotrexate (MTX) exposure during pregnancy is associated with embryopathy. The teratogenic potential of MTX at dosages typically used in the treatment rheumatic diseases remains uncertain. aim this study was to evaluate risk spontaneous abortion, major birth defects, elective termination pregnancy, shortened gestational age delivery, and reduced weight women exposed MTX. Methods Pregnancy outcome taking (≤30 mg/week) either after conception or within 12 weeks before...
Lithium taken during the first trimester of pregnancy appears to increase risk cardiovascular anomalies in infants, although some these resolve spontaneously. also raises likelihood miscarriage. On other hand, illness recurrence is high for women who discontinue taking medication pregnancy, and so decision should be made on an individual basis. It recommended that treated with lithium organogenesis receive fetal echocardiography level-2 ultrasound.
Objectives Glucagon-like peptide 1 receptor agonists (GLP1-RA) are indicated for the treatment of type 2 diabetes and more recently weight loss. The aim this study was to assess risks associated with GLP1-RA exposure during early pregnancy. Design This multicentre, observational prospective cohort compared pregnancy outcomes in women exposed either or obesity those two reference groups: (1) at least one non-GLP1-RA antidiabetic drug first trimester (2) a group overweight/obese without...
Article AbstractObjective: To assess the safety of butyrophenone neuroleptics haloperidol and penfluridol in pregnancy. Method: The rate major anomalies was compared between a cohort pregnant women counseled for gestational exposure to or control group nonteratogen exposure. This multicenter, prospective, controlled study conducted within European Network Teratology Information Services (ENTIS) included who contacted 1 4 teratology information services counseling January 1989 December 2001....
Metronidazole is an important antibacterial agent commonly used in women of reproductive age. Its use pregnancy a reason for concern and their health care providers. The objective was to examine the fetal safety metronidazole.The Israeli Teratogen Information Service prospectively collected followed up 228 exposed metronidazole pregnancy, 86.2% whom with first-trimester exposure. Pregnancy outcome compared that control group, who were counseled during same period nonteratogenic...
Summary Background : Proton pump inhibitors are used to treat gastro‐oesophageal reflux and peptic ulcers. Gastro‐oesophageal is a common condition in pregnancy. Human pregnancy experience with lansoprazole or pantoprazole very limited. More data exist on the safety of omeprazole Aim To assess proton Methods The rate major anomalies was compared between pregnant women exposed omeprazole, lanzoprazole, control group counselled for non‐teratogens. study design multicentre ( n = 8),...
Propylthiouracil (PTU) is presently considered to be the treatment of choice for hyperthyroidism in pregnancy. It known cross human placenta, and therefore may affect fetus. The major aims this study were evaluate rate anomalies report fetal goitre, accompanied by hypothyroidism, fetuses/ newborns mothers after utero exposure PTU.Prospective observational controlled cohort PTU-exposed pregnancies women counselled Israeli Teratology Information Service between years 1994 2004 compared with...
ABSTRACT On January 12, 2024 the safety committee of European Medicines Agency (EMA) recommended precautionary measures over a potential risk neurodevelopmental disorders in children born to men treated with valproate. These new recommend patient supervision by specialist management epilepsy, bipolar disorder, or migraine. In United Kingdom, and Healthcare products Regulatory (MHRA) issued far more stringent precaution, warning against prescribing valproate anyone under 55 years age. We,...
The Israeli Teratogen Information Service prospectively followed up 210 pregnancies with first trimester carbamazepine exposure. Pregnancy outcome was compared that of two overlapping controls, matched and general (<i>n</i> = 629), exposed to nonteratogenic agents. Our study suggests a twofold increase in the rate major congenital anomalies (12/160 [carbamazepine] versus 18/560 [general control]; relative risk 2.24; 95% CI 1.1–4.56) birth weight reduction approximately 250 g after utero...
Methylphenidate is a central nervous system stimulant medicinally used in the treatment of attention-deficit disorder with or without hyperactivity (ADD/ADHD). Data on its use human pregnancy are limited. The primary objective study was to evaluate risk major congenital anomalies after exposure methylphenidate for medical indications.In prospective, comparative, multicenter observational performed 4 participating Teratology Information Services (in Jerusalem, Berlin, Newcastle upon Tyne, and...
Introduction: Aligned with the Innovative Medicines Initiative (IMI) ConcePTION project’s goal of advancing drug safety research in pregnancy, we explored feasibility employing a standardized list core data elements (CDEs) and statistical outputs to harmonize collection analysis across various study partners. Methods: Study partners from public institutions pharmaceutical companies extracted pregnancy on disease-modifying therapies for multiple sclerosis their databases, mapped them CDE...