A5010704885- Pregnancy and Medication Impact
- Pharmacological Effects and Toxicity Studies
- Pregnancy and preeclampsia studies
- Pharmaceutical studies and practices
- Cardiovascular Issues in Pregnancy
- Maternal Mental Health During Pregnancy and Postpartum
- Breastfeeding Practices and Influences
- Prenatal Substance Exposure Effects
- Neonatal Respiratory Health Research
- Epilepsy research and treatment
- Reproductive Health and Contraception
- Reproductive System and Pregnancy
- Drug-Induced Adverse Reactions
- Birth, Development, and Health
- Health and Medical Studies
- Child and Adolescent Health
- Cancer Risks and Factors
- Forensic Toxicology and Drug Analysis
- Assisted Reproductive Technology and Twin Pregnancy
- Eosinophilic Esophagitis
- Contact Dermatitis and Allergies
- Drug Transport and Resistance Mechanisms
- Trace Elements in Health
- Orthopaedic implants and arthroplasty
- Acute Lymphoblastic Leukemia research
Humboldt-Universität zu Berlin
2017-2025
Freie Universität Berlin
2017-2025
Charité - Universitätsmedizin Berlin
2016-2025
Barmherzige Brüder Klinikum St. Elisabeth in Straubing
2016-2024
Auguste-Viktoria-Klinik
2019
Berliner Hochschule für Technik
2017
University of Graz
2016
Medical University of Graz
2016
Universitätskinderklinik
2016
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2015
Recent studies have suggested a possible association between maternal use of selective serotonin reuptake inhibitors (SSRIs) in early pregnancy and cardiovascular anomalies. The aim the present study was to evaluate teratogenic risk paroxetine fluoxetine.
Abstract Background A specific phenotype of methimazole (MMI) induced malformations has recently been postulated. MMI embryopathy is characterized by minor dysmorphic features, choanal atresia and/or esophageal atresia, growth retardation, and developmental delay. Methods We prospectively studied the outcome pregnancy in 241 women counseled 10 Teratology Information Services (TIS) European Network (ENTIS) because exposure, compared them with those 1,089 pregnant referred to TIS exposure...
After maternal exposure to mycophenolate in pregnancy a high number of fetal losses and specific pattern birth defects consisting microtia, cleft lip, other anomalies have been reported. However, so far, prospective data on outcome allowing quantitative risk assessment are missing. We report 57 prospectively ascertained pregnancies after therapy with (mycophenolate mofetil or sodium) identified by European Teratology Information Services (ETIS) through their consultation process. The these...
Objective High‐dose methotrexate (MTX) exposure during pregnancy is associated with embryopathy. The teratogenic potential of MTX at dosages typically used in the treatment rheumatic diseases remains uncertain. aim this study was to evaluate risk spontaneous abortion, major birth defects, elective termination pregnancy, shortened gestational age delivery, and reduced weight women exposed MTX. Methods Pregnancy outcome taking (≤30 mg/week) either after conception or within 12 weeks before...
Aims TNF‐α inhibitors are considered relatively safe in pregnancy but experience is still limited. The aim of this study was to evaluate the risk major birth defects, spontaneous abortion, preterm and reduced weight after first trimester exposure inhibitors. Methods Pregnancy outcomes women on adalimumab, infliximab, etanercept, certolizumab pegol or golimumab were evaluated a prospective observational cohort compared with non‐exposed random sample. samples drawn from pregnancies identified...
Background There is still uncertainty about the management of pregnant women exposed to immunomodulatory therapy for treatment multiple sclerosis (MS) in pregnancy. Objective To assess safety interferon (IFN)-β1a, IFN-β1b, and glatiramer acetate (GA) MS during Methods A prospective observational cohort study was performed with patients enrolled through a drug risk assessment by Teratology Information Service (TIS), Berlin, from 1996 2007. Pregnancy outcomes four groups were compared: two...
Article AbstractObjective: To assess the safety of butyrophenone neuroleptics haloperidol and penfluridol in pregnancy. Method: The rate major anomalies was compared between a cohort pregnant women counseled for gestational exposure to or control group nonteratogen exposure. This multicenter, prospective, controlled study conducted within European Network Teratology Information Services (ENTIS) included who contacted 1 4 teratology information services counseling January 1989 December 2001....
Abstract BACKGROUND Like angiotensin converting enzyme (ACE) inhibitors II (AT II)‐receptor‐antagonists may cause persistent or even lethal fetotoxic defects when used during the late second third trimester. There are insufficient data on first‐trimester exposure to these substances in terms of teratogenicity. The two databases Berlin Teratology Information Service (TIS) were evaluated for pregnancy outcome following AT II‐receptor‐antagonists. One database covers case reports newborns with...
Summary Background : Proton pump inhibitors are used to treat gastro‐oesophageal reflux and peptic ulcers. Gastro‐oesophageal is a common condition in pregnancy. Human pregnancy experience with lansoprazole or pantoprazole very limited. More data exist on the safety of omeprazole Aim To assess proton Methods The rate major anomalies was compared between pregnant women exposed omeprazole, lanzoprazole, control group counselled for non‐teratogens. study design multicentre ( n = 8),...
Concerns have been raised about the use of topical retinoids since publication isolated cases characteristic retinoid embryopathy, originally described after oral use. A collaborative study European Network Teratology Information Services was carried out to evaluate rate congenital malformations following first-trimester exposure. population 235 exposed pregnant women compared with 444 controls. No significant differences were observed between groups regard rates spontaneous abortion (odds...
Background Restless legs syndrome ( RLS ) is related to parity, and its symptoms may worsen during pregnancy. Treatment with levodopa or dopamine agonists the first‐line therapy for ; however, there are limited data on treatment in We therefore assessed safety of levodopa, pramipexole, rotigotine, ropinirole Methods Prospective documentation pregnancies exposed between 1998 2011 was evaluated as their outcome (teratogenicity fetotoxicity) by B erlin I nstitute C linical T eratology D rug R...
Published experience on first trimester exposure to methyldopa is still limited, although it recommended as first-line treatment for hypertensive disorders in pregnancy most countries. The primary aim of this prospective observational cohort study was analyze the rate major birth defects and spontaneous abortions women with therapy chronic hypertension. Outcomes 261 pregnancies 526 comparison without hypertension reported German Embryotox pharmacovigilance institute were evaluated. exposed...
Abstract Background Non-steroidal anti-inflammatory drugs (NSAID) are frequently used to treat pain, fever and inflammatory conditions. Due evidenced fetotoxicity, treatment with NSAID metamizole should be avoided in the 3rd trimester of pregnancy. There is an ongoing debate on fetotoxic risk 2nd use which why we have conducted this study. Methods In observational cohort study outcome pregnancies and/or exposure (study n = 1092) was compared exposed 1st only (comparison cohort, 1154). The...