A5088544413- Prenatal Screening and Diagnostics
- Congenital Anomalies and Fetal Surgery
- Pregnancy and preeclampsia studies
- Congenital limb and hand anomalies
- Congenital Heart Disease Studies
- Assisted Reproductive Technology and Twin Pregnancy
- Urological Disorders and Treatments
- Cleft Lip and Palate Research
- Folate and B Vitamins Research
- Cardiovascular Issues in Pregnancy
- Gestational Diabetes Research and Management
- Child and Adolescent Health
- Maternal and fetal healthcare
- Pregnancy and Medication Impact
- Maternal Mental Health During Pregnancy and Postpartum
- Pharmacological Effects and Toxicity Studies
- Prenatal Substance Exposure Effects
- Parvovirus B19 Infection Studies
- Tracheal and airway disorders
- Maternal and Perinatal Health Interventions
- Genomic variations and chromosomal abnormalities
- Craniofacial Disorders and Treatments
- Reproductive Health and Technologies
- Esophageal and GI Pathology
- Research in Social Sciences
Finnish Institute for Health and Welfare
2013-2024
NTL Institute for Applied Behavioral Science
2011
Nordic School of Public Health
2011
Research Council of Finland
1999-2010
Aalto University
2010
National Institutes of Health
2010
Weatherford College
2005
New Orleans Public Library
2005
University of Oulu
2002
Helsinki University Hospital
1989
What are the long term trends in total (live births, fetal deaths, and terminations of pregnancy for anomaly) live birth prevalence neural tube defects (NTD) Europe, where many countries have issued recommendations folic acid supplementation but a policy mandatory fortification food does not exist?This was population based, observational study using data on 11,353 cases NTD associated with chromosomal anomalies, including 4162 anencephaly 5776 spina bifida from 28 EUROCAT (European...
Objective To validate the estimates of Global Burden Disease (GBD) due to congenital anomaly for Europe by comparing infant mortality data collected EUROCAT registries with WHO Mortality Database, and assessing significance stillbirths terminations pregnancy fetal (TOPFA) in interpretation statistics. Design, setting outcome measures is a network collecting on live births, deaths from 20 weeks’ gestation TOPFA. Data 29 19 countries were analysed 2005–2009, (deaths births at age <1 year)...
<h3>Abstract</h3> <b>Objectives</b> To evaluate the effectiveness of policies and recommendations on folic acid aimed at reducing occurrence neural tube defects. <b>Design</b> Retrospective cohort study births monitored by birth defect registries. <b>Setting</b> 13 defects registries monitoring rates from 1988 to 1998 in Norway, Finland, Northern Netherlands, England Wales, Ireland, France (Paris, Strasbourg, Central East), Hungary, Italy (Emilia Romagna Campania), Portugal, Israel. Cases...
To estimate the risk of major congenital anomalies after exposure to selective serotonin reuptake inhibitors during pregnancy.A retrospective cohort study based on national population-based registers (years 1996-2006) births, anomalies, and terminations pregnancy because severe fetal (maintained by National Institute for Health Welfare, source offspring population n=635,583) drug reimbursements (Social Insurance Institution) linked a personal identification number. Offspring exposed first...
Data provided by nine registries based in European and Latin America countries were analyzed to assess whether there is an excess of malformations twins compared singletons. Specific congenital coded according the ninth revision International Classification Diseases (ICD). Malformation rates rate ratios (RR) for singletons calculated each registry, homogeneity RRs was tested using test Breslow Day. If departure from different not significant, registry-adjusted with 95% confidence intervals...
Background and aims. Effects of caseload organization care on outcomes biliary atresia (BA) remain unclear. We compared before after national centralization BA treatment in Finland with a population 5.4 million people 60,000 live births/year. Methods. All children born from 1987 to 2010 were included. Complete patient identification was ascertained the Register Congenital Malformations. Hospital records reviewed for confirmation diagnosis, treatment, follow-up data. Clearance jaundice (serum...
BACKGROUND: Two crucial issues relative to the benefits and impact of folic acid in prevention birth defects are whether supplementation recommendations alone, without fortification, effective reducing population-wide rates neural tube (NTDs), such policies can reduce occurrence other defects. Using data from 15 registries, we assessed trends 14 major defects, including NTDs, areas with official or fortification assess effectiveness on a wide range METHODS: We evaluated surveillance through...
STUDY QUESTIONIs there a different risk for major congenital anomalies (CAs) in children born after frozen–thawed embryo transfer (FET) compared with fresh (ET)?
The aim of this population-based nationwide drugs and pregnancy surveillance system was to get basic information on the use prescribed during achieve more detailed drug exposure-outcome associations with data obtained from Finnish national health registers.The are based all pregnancies ending in births (n = 632,629) or termination (TOP) 117,255) Finland between 1996 2006. containing maternal background factors, chronic diseases purchases pregnancy, born children, induced abortions, perinatal...
Abstract Aim The birth prevalence of sacrococcygeal teratoma ( SCT ) has been reported to range from 1:27 000 1:40 000. We assessed the population‐based and clinical presentation over 22 years. Methods identified all cases , including live births, stillbirths terminations pregnancy TOP s), in Finnish Register Congenital Malformations, covering 1987–2008. Data on prenatal diagnoses, outcomes, infant deaths associated anomalies were collected. Results One hundred twenty four among 1 331 699...
The study evaluated the sex distribution of major isolated malformations and common trisomies among a large geographically varied sample. Eighteen registries from 24 countries contributed cases, which were centrally reviewed classified in three clinical types as isolated, associated, or syndromic. We selected cases 26 defects (n = 108,534); trisomy 21, 18, 13 30,114); other syndromes 2,898); multiple congenital anomalies 24,197), for total 165,743 cases. observed significant deviation...
Abstract Arthrogryposis multiplex congenita is a heterogeneous group of disorders characterized by multiple contractures with an estimated frequency 1 in 3,000 births. With improving diagnostic methods, increasing numbers fetuses arthrogryposis are found. The pathogenetic mechanisms relatively well known but the epidemiology and genetics prenatally lethal forms less known. In this study we collected all cases diagnosed Finland during 1987–2002 including live born infants, stillbirths,...
Objectives: To identify preferential associations between oral clefts (CL = cleft lip only, CLP with palate, CP palate) and nonoral anomalies, to interpret them on clinical grounds, and, based the patterns of associated defects, establish whether CL are different conditions. Design And Settings: Included were 1416 cases 131, 565, 720), among 8304 live- stillborn infants multiple congenital from 6,559,028 births reported International Clearinghouse for Birth Defects Surveillance Research by...
Some, though not all studies have reported an increased risk for mental health problems after induced abortion. Problems with design and data compromised these the generalisation of their results. The Finnish Medication Pregnancy database (N = 622 671 births 114 518 abortions other than fetal reasons) in 1996-2006 was utilised to study use psychotropic drugs three months before a pregnancy ending birth or In total 2.1% women 5.1% abortion had used medicine 0-3 pregnancy. Psychotropic drug...
Abstract Objective. To study perinatal mortality associated with placental abruption. Design. Retrospective population using the Finnish Hospital Discharge Register and Medical Birth data. Setting. Finland, 1987–2005. Population. Pregnancies abruption all other births without Methods. The national were used to identify pregnancies Demographic data delivery outcomes collected retrospectively. Perinatal was compared that in births. Potential risk factors analysed. Main outcome measures....
Offspring of cancer survivors (CS) may be at risk for congenital anomalies due to the mutagenic therapies received by their parents. Our population‐based cohort study aimed investigate in offspring CS compared siblings. Using Finnish Cancer Registry, Central Population Register, and Hospital Discharge we identified hospital contacts 6,862 (early‐onset between 1953 2004) 35,690 Associations were evaluated using generalized linear regression modelling. The ratio (3.2%) was slightly, but...