A5069808930- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Infant Development and Preterm Care
- Neonatal and fetal brain pathology
- Vitamin D Research Studies
- Pregnancy and preeclampsia studies
- Infant Nutrition and Health
- Neuroscience of respiration and sleep
- Gestational Diabetes Research and Management
- Congenital Diaphragmatic Hernia Studies
- Obesity, Physical Activity, Diet
- Maternal Mental Health During Pregnancy and Postpartum
- Breastfeeding Practices and Influences
- Child Nutrition and Feeding Issues
- Preterm Birth and Chorioamnionitis
- Bone health and osteoporosis research
- Maternal and fetal healthcare
- Congenital Heart Disease Studies
- Respiratory Support and Mechanisms
- Vitamin C and Antioxidants Research
- Stress Responses and Cortisol
- Sleep and related disorders
- Bariatric Surgery and Outcomes
- Sepsis Diagnosis and Treatment
- Parathyroid Disorders and Treatments
Helsinki University Hospital
2015-2024
University of Helsinki
2015-2024
Lappeenranta-Lahti University of Technology
2024
Children's Hospital
1989-2019
University of Warwick
2017-2018
Karolinska University Hospital
2018
Helsinki Children's Hospital
2003-2017
Royal Women's Hospital
2016
The University of Melbourne
2016
RELX Group (Netherlands)
2014
OBJECTIVE To assess whether gestational diabetes mellitus (GDM) can be prevented by a moderate lifestyle intervention in pregnant women who are at high risk for the disease. RESEARCH DESIGN AND METHODS Two hundred ninety-three with history of GDM and/or prepregnancy BMI ≥30 kg/m2 were enrolled study <20 weeks gestation and randomly allocated to group (n = 155) or control 138). Each subject received individualized counseling on diet, physical activity, weight from trained nurses, had...
Microbial colonization of the neonatal gut involves maternal seeding, which is partially disrupted in cesarean-born infants and after intrapartum antibiotic prophylaxis. However, other physically close individuals could complement such seeding. To assess role both parents induced we analyzed two longitudinal metagenomic datasets (health early life microbiota [HELMi]: N = 74 infants, 398 samples, SECFLOR: 7 35 samples) with who received fecal transplantation (FMT). We found that father...
Spontaneous transients of correlated activity are a characteristic feature immature brain structures, where they thought to be crucial for the establishment precise neuronal connectivity. Studies on experimental animals have shown that this kind early in cortical structures is composed long-lasting, intermittent network events, which undergo developmental decline closely paralleled by maturation GABAergic inhibition. In order examine whether similar events occur human cortex, we performed...
By means of a multivariate regression analysis, we have studied the importance atopy, “wet” and “dry” occupations, domestic work as risk factors for hand eczema. Hand eczema was identified by questionnaire. The cohort consisted 2452 newly employed hospital workers with median follow‐up lime 20 months. Of total studied. 86% were female. occurrence in 4 occupational groups were: nursing staff 41% kitchen workers/cleaners 37%, office 25% caretakers craftsmen 17%. A topic dermatitis increased...
Children with very low birth weight (<1500 g) are at increased risk for attention deficit hyperactivity disorder (ADHD). Whether this continues into adulthood is unknown. The authors assessed behavioral symptoms of ADHD in a well-characterized cohort very-low-birth-weight young adults who were either small gestational age (less than two standard deviations below the Finnish mean) or appropriate (within mean).A total 162 subjects (small age: N=52; N=110) and 172 term comparison 18 to 27 years...
It remains unclear whether it is more detrimental to be born too early or small in relation symptoms of attention deficit/hyperactivity disorder (ADHD). Thus, we tested preterm birth and body size at adjusted for gestational age are independently associated with ADHD children. A longitudinal regional cohort study comprising 1535 live-born infants between 03/15/1985 03/14/1986 admitted the neonatal wards 658 randomly recruited non-admitted infants, Finland. The present sample comprised 828...
Little is known about the mental health outcomes of very low-birth-weight (VLBW) (< 1500 g) infants in young adulthood.To test whether adults aged 18 to 27 years with VLBW differ from term control subjects depressive symptoms, current use antidepressant medication, and rate depression diagnosed by a physician.Retrospective longitudinal study.Academic research.A total 162 (response rate, 65.1%) 172 54.8%) born between February 22, 1978, November 8, 1985, Helsinki, Finland.Antidepressant use,...
OBJECTIVE. The aim of the study was to investigate whether weight, length, BMI (kilograms per meter squared), and head circumference at birth their postnatal growth are associated with cognitive abilities 56 months age among infants born term. PATIENTS AND METHODS. Our sample composed 1056 Finnish children term, (37 41 weeks) free any major impairments. Weight, were measured 5, 20, age, calculated. We assessed by conducting tests general reasoning, visual-motor integration, verbal...
In this prospective study, 87 children were followed up from birth to 14 months with data on maternal vitamin D status during the pregnancy. Postnatal supplementation improved but only partly eliminated differences in bone variables induced by fetal period.
Simultaneous maternal heart rate registration during external fetal monitoring reduces the incidence of neonatal asphyxia-related outcomes.
Leptin is an adipocyte-derived peptide hormone regulating energy balance in experimental animals.Although the physiological function of leptin humans still unclear, its secretion closely related to fat mass adult humans.To examine how fetal growth correlates with levels at birth, umbilical cord venous blood sample was obtained delivery from 50 term newborn infants.Twenty-eight infants had birth weights appropriate for gestational age (AGA; mean Ϯ SEM, 3362 90 g; relative weight, Ϫ0.08 0.2...
OBJECTIVE. We investigated whether very low birth weight (&lt;1500 g) is associated with the risk of sleep-disordered breathing in young adulthood. METHODS. The study was a retrospective longitudinal 158 adults born and 169 term-born control subjects (aged 18.5–27.1 years). principal outcome variable defined as chronic snoring. RESULTS. crude prevalence snoring similar both groups: 15.8% for group versus 13.6% group. However, after controlling confounding variables multivariate logistic...
Context: Guidelines in Finland recommend 10 μg of vitamin D3 daily for all infants. Recent observations suggest that this may be insufficient to maintain optimal serum 25-hydroxyvitamin D (S-25-OHD). Objective: The aim the study was evaluate effects various doses and determine a dose ensuring S-25-OHD at least 80 nmol/liter infants without signs excess. Design: We conducted randomized double-blind intervention study. Cord blood obtained birth S-25-OHD; 113 were receive 10, 30, or 40 μg/d...
Neonatal outcomes vary by gestational age. We evaluated the association of early-term, full-term, and postterm birth with asphyxia, neurologic morbidity, perinatal mortality.Our register-based study used retrospective data on 214 465 early-term (37(+0)-38(+6) weeks), 859 827 full-term (39(+0)-41(+6)), 55 189 (≥42(+0)) live-born singletons during 1989-2008 in Finland. Asphyxia parameters were umbilical cord pH Apgar score at 1 5 minutes. Neurologic morbidity outcome measures cerebral palsy...
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BACKGROUND AND OBJECTIVES: Lung function attained in young adulthood is 1 of the strongest predictors obstructive airways disease later life. Adults born preterm at very low birth weight (VLBW; &lt;1500 g) who have experienced bronchopulmonary dysplasia (BPD) reduced lung function. We studied association with VLBW and BPD other prenatal neonatal conditions. METHODS: performed spirometry for 160 subjects (29 according to Northway criteria) aged 18 27 years 162 term control group-matched...