A5015130580- Infant Development and Preterm Care
- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Infant Nutrition and Health
- Children's Physical and Motor Development
- Maternal Mental Health During Pregnancy and Postpartum
- Obesity, Physical Activity, Diet
- Cerebral Palsy and Movement Disorders
- Advanced Neuroimaging Techniques and Applications
- Anesthesia and Neurotoxicity Research
- EEG and Brain-Computer Interfaces
- Bariatric Surgery and Outcomes
- Sleep and related disorders
- Child Nutrition and Feeding Issues
- Infant Health and Development
- Attention Deficit Hyperactivity Disorder
- Family and Disability Support Research
- Research in Social Sciences
- Fetal and Pediatric Neurological Disorders
- Child and Adolescent Psychosocial and Emotional Development
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Circadian rhythm and melatonin
University of Helsinki
2015-2025
Helsinki University Hospital
2015-2025
Helsinki Children's Hospital
2015-2022
University of Warwick
2017-2018
Children's Hospital
2013-2016
It remains unclear whether it is more detrimental to be born too early or small in relation symptoms of attention deficit/hyperactivity disorder (ADHD). Thus, we tested preterm birth and body size at adjusted for gestational age are independently associated with ADHD children. A longitudinal regional cohort study comprising 1535 live-born infants between 03/15/1985 03/14/1986 admitted the neonatal wards 658 randomly recruited non-admitted infants, Finland. The present sample comprised 828...
OBJECTIVE. The aim of the study was to investigate whether weight, length, BMI (kilograms per meter squared), and head circumference at birth their postnatal growth are associated with cognitive abilities 56 months age among infants born term. PATIENTS AND METHODS. Our sample composed 1056 Finnish children term, (37 41 weeks) free any major impairments. Weight, were measured 5, 20, age, calculated. We assessed by conducting tests general reasoning, visual-motor integration, verbal...
Objective Low physical activity (PA) is a major risk factor for cardiovascular and metabolic disorders in all age groups. We measured intensity volume of PA examined the associations between syndrome (MS), its components body composition among young Finnish adults. Research Design Methods The study comprises 991 men women born 1985-86, who participated clinical during years 2009-11 which included assessments metabolism, PA. Objectively (SenseWear Armband) five-day data was available from 737...
Preterm birth is the greatest risk factor for lifelong neurocognitive deficits, globally. The effect of prematurity on early cortical network function has, however, remained poorly understood. Here, we developed a novel methodology that allows reliable assessment functional connectivity in neonatal brain activity at millisecond and multisecond scales terms phase amplitude correlations, respectively. We measured scalp electroencephalography term-equivalent age infants exposed to very as well...
<i>Background:</i> Dexamethasone treatment is associated with an increased risk of cerebral palsy (CP). Early hydrocortisone (HC) may decrease the incidence bronchopulmonary dysplasia; however, long-term effects are still under evaluation. Follow-up randomized studies concerning early HC essential to confirm safety. <i>Objective:</i> We hypothesized that in very preterm infants does not impair neurologic outcome. <i>Methods:</i> report follow-up data from...
Atypical sensory processing is common in children born extremely prematurely. We investigated abilities low gestational age (ELGA) and analysed associated neonatal risk factors, neuroanatomical findings neurodevelopmental outcome.We carried out a prospective study of 44 ELGA children, including 42 who had undergone brain magnetic resonance imaging (MRI) at term-equivalent age, when they were 2 years corrected age. Their assessed with the Infant/Toddler Sensory Profile questionnaire their...
Infants are well known to seek eye contact, and they prefer fixate on developmentally meaningful objects, such as the human face. It is also known, that visual abilities important for developmental cascades of cognition from later infancy childhood. less understood, however, whether newborn relate cognitive development, ability fixation can be assigned early microstructural maturation. Here, we investigate relationship between (VF) gaze behavior (GB) performance in visuomotor reasoning tasks...
Maternal gestational diabetes mellitus (GDM) and prepregnancy overweight/obesity [body mass index (BMI) ≥25 kg/m2] might adversely affect offspring cardiometabolic health.To assess the associations between maternal GDM with adult risk factors.Longitudinal cohort study (ESTER Pregnancy Disorders Study Arvo Ylppö Longitudinal Study).Province of Uusimaa Northern Finland.At a mean age 24.1 ± 1.3 years, we classified as mothers regardless BMI (OGDM; n = 193); normoglycemic (ONO; 157); <25 kg/m2...
Abstract Background Extremely low gestational age newborns (ELGANs) are at risk of neurodevelopmental impairments that may originate in early NICU care. We hypothesized oxygen saturations (SpO 2 ), arterial pO levels, and supplemental (FiO ) would associate with later neuroanatomic changes. Methods SpO , blood gases, FiO from 73 ELGANs (GA 26.4 ± 1.2; BW 867 179 g) during the first 3 postnatal days were correlated white matter injury (WM, MRI, n = 69), secondary cortical somatosensory...
<h3>Background:</h3> Weekly repeated antenatal corticosteroid treatment improves respiratory outcome but decreases fetal growth and may impair neurodevelopmental outcome. We have previously reported that a single repeat betamethasone (BM) dose neither decreased nor improved the of preterm infants during first hospitalisation. <h3>Objective:</h3> To study prospectively whether BM influences neurodevelopment within 2 years. <h3>Design:</h3> Women with imminent delivery before 34.0 gestational...
Early mother‐child interaction is one of the factors suggested to have an impact on neurocognitive development extremely low gestational age ( ELGA ) children. Our aim was examine associations with outcome, neurological impairments and neonatal brain injuries in A prospective study 48 children, born before 28 weeks (26.3 ± 1.2 weeks, birth weight 876 g 194 g), 16 term controls. Brain MRI performed at term‐equivalent age. At two years corrected age, assessed a structured play situation using...
We evaluated the neurodevelopment and growth of five- to seven-year-old children who had participated in a randomised trial early low-dose hydrocortisone treatment prevent bronchopulmonary dysplasia.The 51 infants original study birthweights 501-1250 g gestational ages 23-30 weeks, required mechanical ventilation during first 24 hours received or placebo for 10 days. The majority (80%) 90% survived seven years age this follow-up their growth, neuromotor, cognitive speech development were...
Summary Experimental sleep deprivation studies suggest that insufficient and circadian misalignment associates with poorer executive function. It is not known whether this association translates to naturally occurring patterns. A total of 512 full‐term‐born members the Arvo Ylppö Longitudinal Study [mean age = 25.3, standard deviation ( SD ) 0.65] (44.3% men) wore actigraphs define duration, its irregularity rhythm (sleep mid‐point) during a 1‐week period (mean 6.9 nights, 1.7)....
Empirical evidence suggests that prenatal growth is associated with attention deficit/hyperactivity disorder (ADHD) and its symptoms. Data on the importance of postnatal is, however scanty. We studied whether pre- up to 56 months symptoms ADHD in children. A longitudinal regional birth cohort study comprising 893 children followed months. The associations between parent-rated child were analyzed multiple linear regression analyses repeated-measures analyzes covariance. Children born lighter,...
We explored whether repeated dose of antenatal betamethasone and variation in intrauterine growth prematurely born children predict temperament characteristics at the age 2 years.The patients (n = 142) were (mean gestational age: 31.0 weeks; range: 24.6-35.0 weeks) who participated a randomized blinded trial testing effects imminent preterm birth. Fetal was estimated as weight, length, head circumference SDs according to Finnish charts. Parents assessed their toddlers' with 201 items Early...