A5062488020- Gestational Diabetes Research and Management
- Bariatric Surgery and Outcomes
- Obesity and Health Practices
- Diabetes Management and Research
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Heart Rate Variability and Autonomic Control
- Cardiovascular Issues in Pregnancy
- Adipose Tissue and Metabolism
- Physical Activity and Health
- Obesity, Physical Activity, Diet
- Regulation of Appetite and Obesity
- Emotion and Mood Recognition
- Pregnancy-related medical research
- Apelin-related biomedical research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Fatty Acid Research and Health
- Mental Health via Writing
- Ovarian function and disorders
- Cardiovascular Disease and Adiposity
- Adrenal Hormones and Disorders
- Blood Coagulation and Thrombosis Mechanisms
- Behavioral Health and Interventions
- Diabetes Treatment and Management
Helsinki University Hospital
2008-2023
University of Helsinki
2015-2022
Tampere University
2018
Jorvi Hospital
2002-2016
GTx (United States)
2012
Central University
2012
OBJECTIVE To assess whether gestational diabetes mellitus (GDM) can be prevented by a moderate lifestyle intervention in pregnant women who are at high risk for the disease. RESEARCH DESIGN AND METHODS Two hundred ninety-three with history of GDM and/or prepregnancy BMI ≥30 kg/m2 were enrolled study <20 weeks gestation and randomly allocated to group (n = 155) or control 138). Each subject received individualized counseling on diet, physical activity, weight from trained nurses, had...
Maternal overweight, obesity and consequently the incidence of gestational diabetes are increasing rapidly worldwide. The objective study was to assess efficacy cost-effectiveness a combined diet physical activity intervention implemented before, during after pregnancy in primary health care setting for preventing diabetes, later type 2 other metabolic consequences.RADIEL is randomized controlled multi-center trial women at high risk (a previous history or prepregnancy BMI ≥30 kg/m2)....
Good metabolic control maintained throughout pregnancy reduces maternal and fetal complications in diabetic women. The long-acting insulin analogue glargine has 24-h persistence a peakless action profile, could contribute to more stable daily plasma glucose levels improved glycemic control. We evaluated the associated with during comparison conventional basal therapy.Retrospective case-control analysis of 100 type 1 pregnancies intermediate-acting NPH or prior conception...
Lifestyle intervention studies performed during pregnancy have shown inconsistent results in relation to prevention of gestational diabetes mellitus (GDM). Therefore, the aim this study was assess effect an initiated already before GDM high-risk women.A randomized controlled trial conducted four Finnish maternity hospitals between years 2008 and 2014. Altogether 228 women planning were (n=116) or a control group (n=112). The risk factors body mass index ≥30 kg/m2 (n=46), prior (n=120), both...
Objective Postmenopausal phase expresses many unfavourable physiological changes that lead to increased risk for cardiovascular disease. We compared the effect of two sympatholytic antihypertensive drug treatments, centrally acting imidazoline receptor-1 agonist moxonidine and peripherally β-blocking agent atenolol on sensitive inflammatory markers in overweight postmenopausal women with diastolic hypertension. Methods This was a multicentre, multinational double-blinded, prospective study...
Objective To study the incidence of gestational diabetes mellitus (GDM) in relation to phenotypic characteristics and weight gain (GWG) among women at high risk for GDM.
Diabet. Med. 27, 988–994 (2010) Abstract Aims Autonomic nervous system dysfunction is observed in Type 2 diabetes. As gestational diabetes a potent risk factor of later diabetes, we set out to determine whether autonomic imbalance could already be women with this condition. Because activity the sympathetic tends relatively stable nocturnal hours, performed study at night. Research design and methods We studied 41 22 healthy pregnant controls 14 non‐pregnant controls. assayed plasma...
This study examined the associations of cardiorespiratory fitness (CRF) and leisure-time physical activity (LTPA) with health-related quality life (HRQoL) in women at risk for gestational diabetes mellitus (GDM). The participants were 39 planning pregnancy a history GDM and/or BMI >29 kg/m2 . We assessed CRF by measuring maximal oxygen consumption (VO2max ) during incremental cycle ergometer exercise until voluntary fatigue. LTPA was self-reported, HRQoL SF-36 Health Survey (SF-36). mean...
We examined serum cholesterol synthesis and absorption markers their association with neonatal birth weight in obese pregnancies affected by gestational diabetes mellitus (GDM). Pregnant women at risk for GDM (BMI >30 kg/m2) were enrolled from maternity clinics Finland. was determined the results of an oral glucose tolerance test. Serum samples collected six time-points, one each trimester pregnancy, 6 weeks, months, 12 months postpartum. Analysis squalene noncholesterol sterols gas-liquid...
Abstract Background Gestational diabetes is a prediabetic state. Sub‐clinical inflammation may play role in the transition from gestational to type 2 diabetes; of autonomic nervous system as mediating has been raised. We aimed study association sympathetic and sub‐clinical women with diabetes. Methods studied 41 Caucasian 22 healthy pregnant 14 non‐pregnant controls. assayed plasma noradrenaline, insulin, C‐reactive protein, interleukin‐6, insulin growth factor‐1, serum amyloid A, steroid...
Gestational diabetes is associated with increased risk for venous thromboembolism. Activation of sympathetic nervous system affects blood coagulation, fibrinolysis and platelet activation by several mechanisms. We aimed to study the relationship system, coagulation function in gestational diabetes. Forty-one white women diabetes, 22 healthy pregnant 14 nonpregnant controls were studied. assayed serial nocturnal (at 12 p.m., 4 a.m. 7 a.m.) changes adrenergic transmitter noradrenaline,...
In polycystic ovary syndrome (PCOS), cardiovascular risk is increased. Peak O2 uptake (V˙O2peak) predicts the risk. We were first to examine contribution of systemic delivery and arteriovenous difference V˙O2peak in overweight obese women with PCOS. Fifteen or PCOS 15 age-, anthropometry-, physical activity-matched control performed a maximal incremental cycling exercise test. Alveolar gas exchange (volume turbine mass spectrometry), arterial saturation (pulse oximetry), cardiac output (CO)...
Major problems with gestational diabetes (GDM) have been the high frequency of fetal macrosomia, and perinatal complications, especially among mothers needing insulin in addition to diet therapy (1). Both long-acting (LAI) short-acting (SAI) are used, former reduce basal glucose level latter control postprandial peaks after meals. Despite many improvements, has not solved above-mentioned problems. We compared effects SAI LAI on outcome insulin-requiring GDM. hypothesized that monitoring...
Abstract Background Insulin resistance (IR) is a globally prevalent condition in which tissues’ response to insulin diminished. Cardiorespiratory fitness (peak O2 uptake (VO2peak)) determined by Fick’s equation (VO2 = cardiac output (CO) × arteriovenous difference (Ca-vO2) heart rate stroke volume (SV) Ca-vO2) and diffusion law diffusive conductance (DO2) constant k venous pressure (PvO2)). Several studies suggest an association between IR decreased VO2peak, but the has been questioned...
Data attrition has been a common problem in longitudinal lifestyle interventions. The contributors to technology-supported physical activity interventions have not thoroughly studied.The present study examined the roles of personality characteristics and indicators psychological well-being data within technology-supported, intervention with overweight adults.Participants (N=89) were adults from Motivation Makes Move! study. was studied after 3-month follow-up. Participants' using Short Five...