A5051498958- Venous Thromboembolism Diagnosis and Management
- Platelet Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Hemophilia Treatment and Research
- Atrial Fibrillation Management and Outcomes
- Heparin-Induced Thrombocytopenia and Thrombosis
- Blood properties and coagulation
- Peripheral Artery Disease Management
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Acute Myocardial Infarction Research
- Blood groups and transfusion
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Central Venous Catheters and Hemodialysis
- Blood disorders and treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lipoproteins and Cardiovascular Health
- Hemostasis and retained surgical items
- Research in Social Sciences
- Cerebrovascular and Carotid Artery Diseases
- Protease and Inhibitor Mechanisms
- Chronic Myeloid Leukemia Treatments
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
Helsinki University Hospital
2016-2025
University of Helsinki
2016-2025
Wihuri Research Institute
1999-2025
Finnish Institute for Health and Welfare
2021-2024
Finland University
2024
University Medical Center Utrecht
2023
Hospital District of Helsinki and Uusimaa
2001-2022
Tampere University
2018
Tampere University Hospital
2018
Invalidisäätiö
2017
AimsMore intense platelet-directed therapy for acute coronary syndrome (ACS) may increase bleeding risk. The aim of the current analysis was to determine rate, clinical impact, and predictors major fatal complications in PLATO study.
VEGF-C is a recently characterised endothelial growth factor structurally related to vascular (VEGF). We studied the expression of and VEGF in cells peripheral blood umbilical cord CD 34+ cells, representing haematopoietic progenitor cells. Expression was detected CD34+ In mRNA restricted platelets T-cells. contrast pattern VEGF-C, all cell fractions studied, also fresh bone marrow samples acute leukaemia patients, but did not show lineage specificity. polypeptides were present they released...
Patients with severe hemophilia A and factor VIII inhibitors are at increased risk for serious bleeding complications progression to end-stage joint disease. Effective strategies prevent in such patients have not yet been established.We enrolled who were older than 2 years of age, had high-titer inhibitors, used concentrates known as bypassing agents a prospective, randomized, crossover study comparing 6 months anti-inhibitor coagulant complex (AICC), infused prophylactically target dose 85...
Summary. As the management of haemophilia is complex, it essential that those with disorder should have ready access to a range services provided by multidisciplinary team specialists. This document sets out principles comprehensive care in Europe. Within each country there be national organization which oversees provision specialist Comprehensive Care Centres provide entire spectrum clinical and laboratory services. Depending upon size geographical distribution population, network smaller...
Cardiovascular disease is an emerging medical issue in patients with hemophilia (PWH) and its prevalence increasing up to 15% PWH the United States. Atrial fibrillation, acute chronic coronary syndromes, venous thromboembolism, cerebral thrombosis are frequent thrombotic or prothrombotic situations, which require a careful approach fine-tune delicate balance between hemostasis when using both procoagulant anticoagulant treatments. Generally, could be considered as being naturally...
Object. From the moment an intracranial aneurysm ruptures, cerebral blood flow is impaired, and this impairment mainly determines outcome in patients who survive after initial bleeding. The exact mechanism of unknown, but activation coagulation fibrinolysis correlate with clinical condition aneurysmal subarachnoid hemorrhage (SAH). purpose study was to determine whether enoxaparin, a low-molecular-weight heparin, which well-known anticoagulating agent, has any effect on SAH postoperatively....
Insulin resistance is associated with an increased risk of atherothrombotic vascular disease, but the mechanisms are poorly understood. We determined how insulin in vivo regulates platelet activation nonobese and obese subjects by using methods mimicking thrombus formation. Twelve (aged 42±2 years, body mass index 24.0±0.4 kg/m 2 ) 14 43±1 37.2±1.5 were studied under euglycemic hyperinsulinemic (3-hour infusion 1 mU · kg −1 min conditions. Before at end hyperinsulinemia, following...
Immunohistochemical studies of human atherosclerotic lesions have demonstrated the occurrence fibrin deposition and its degradation in arterial wall. We studied fibrinogen, generation thrombin, 40 patients with stable peripheral occlusive disease varying severity, as assessed by ankle/brachial pressure index duplex ultrasonography and/or angiography. Circulating fibrinogen (functional immunological), fibrinopeptide A, thrombin-antithrombin III complex, D-dimer were measured. The severity...
Background and aims: Obesity the metabolic syndrome are established risk factors of venous thromboembolism. As most coagulation produced exclusively by liver non-alcoholic fatty disease (NAFLD) is tightly related to disorders, we aimed at studying association fat with various factor activities. Methods: Plasma prothrombin (PT) activated partial thromboplastin time, activities vWF:RCo, FVII, FVIII, FIX, FXI, FXII, FXIII, fibrinogen D-dimer concentrations were measured in 54 subjects 44...
Laboratory tests to assess novel oral anticoagulants (NOACs) are under evaluation. Routine monitoring is unnecessary, but special circumstances bioactivity assessment becomes crucial. We analyzed the effects of NOACs on coagulation and availability specific assays at different laboratories.Plasma samples spiked with dabigatran (Dabi; 120 300 μg/L) or rivaroxaban (Riva; 60, 146, 305 were sent 115 38 European laboratories, respectively. International normalized ratio (INR) activated partial...
The role of thrombophilia in failing arteriovenous fistula (AVF) among patients with ESRD undergoing hemodialysis is not established. This study aimed to assess whether AVF primary patency associated and coagulation abnormalities.This observational screened 219 between 2002 2004 for before surgery. Thrombophilia included factor V Leiden prothrombin G20210A mutations, protein C antithrombin activities, S. Coagulation abnormalities high VIII:C, homocysteine, fibrinogen, d-dimer levels;...
AimsThe aim of this study was to assess the relationship between sex and clinical outcomes treatment-related complications in patients with ST-elevation or non-ST-elevation acute coronary syndromes (ACS) randomized treatment ticagrelor clopidogrel PLATelet inhibition patient Outcomes (PLATO) trial.
Abstract The effect of chronic stress on tissue-type plasminogen activator (TPA) and inhibitor–1 (PAI-1) antigens was studied in 69 healthy middle-aged men. Chronic stress, defined as feelings fatigue, lack energy, increased irritability, demoralization, positively associated with plasma concentrations PAI-1 antigen but unrelated to TPA. association remained unaltered after controlling for age, smoking, alcohol consumption, physical activity became nonsignificant further abdominal obesity,...
The formation of an arterial thrombus is a dynamic process that depends upon the characteristics blood flow, triggering substrate, and components. We have developed characterized sensitive specific computer-assisted nuclear scintigraphic method to study dynamics platelet deposition on severely damaged vessels both in vitro vivo nonstenotic stenotic flow conditions. Heparinized pig with Indium-111-labeled platelets was perfused for 50 minutes. Method variability static flowing conditions...
A survey of 21 haemophilia doctors, throughout Europe, who care for a total approximately 5000 patients with bleeding disorders addressing practice and opinions regarding prophylaxis in aged 16-24 years adults over 50 years, is presented. The outcome adolescent reduced or stopped was recorded. Eighteen 19 respondents would consider modification established the age group, principal considerations being avoidance risks further concentrate exposure, predicted poor compliance treatment costs....
We sought to describe the differential effect of bleeding events in acute coronary syndromes (ACS) on short- and long-term mortality according their type severity.The PLATO trial randomised 18,624 ACS patients clopidogrel or ticagrelor. Post-randomisation were captured (spontaneous procedure-related), with PLATO, TIMI, GUSTO definitions. The association subsequent short-term (<30 days) (>30 all-cause was assessed using time-dependent Cox proportional hazard models. A model fitted compare...
The immunoreceptor tyrosine-based inhibition motif (ITIM)-containing receptor G6b-B is critical for platelet production and activation. Loss of results in severe macrothrombocytopenia, myelofibrosis aberrant function mice humans. Using a combination immunohistochemistry, affinity chromatography proteomics, we identified the extracellular matrix heparan sulfate (HS) proteoglycan perlecan as binding partner. Subsequent vitro biochemical studies cell-based genetic screen demonstrated that...