A5058673979- Burn Injury Management and Outcomes
- Wound Healing and Treatments
- Injury Epidemiology and Prevention
- Reconstructive Facial Surgery Techniques
- Reconstructive Surgery and Microvascular Techniques
- Cardiac Arrest and Resuscitation
- Dermatologic Treatments and Research
- Electrospun Nanofibers in Biomedical Applications
- Estrogen and related hormone effects
- Head and Neck Surgical Oncology
- Silk-based biomaterials and applications
- Bone Tissue Engineering Materials
- Trauma and Emergency Care Studies
- Restraint-Related Deaths
- Planarian Biology and Electrostimulation
- Disaster Response and Management
- Research in Social Sciences
- Head and Neck Cancer Studies
- Bone fractures and treatments
- Muscle and Compartmental Disorders
- Traumatic Brain Injury Research
- Trauma Management and Diagnosis
- 3D Printing in Biomedical Research
- Surgical Sutures and Adhesives
- Acute Kidney Injury Research
Helsinki University Hospital
2016-2025
University of Helsinki
2016-2025
Jorvi Hospital
2018-2024
Töölö Hospital
1996-2021
Oulu University Hospital
2021
Although new therapeutic approaches for burn treatment have made progress, there is still need better methods to enhance wound healing and recovery especially in severely burned patients. Nanofibrillar cellulose (NFC) has gained attention due its renewable nature, good biocompatibility excellent physical properties that are of importance a range applications pharmaceutical biomedical fields. In the present study, we investigated potential wood based NFC dressing clinical trial on Previously,...
Abstract Psoriatic skin differs distinctly from normal by its thickened epidermis. Most gene expression comparisons utilize full-thickness biopsies, with substantial amount of dermis. We assayed the transcriptomes normal, lesional and non-lesional psoriatic epidermis, sampled as split-thickness grafts, 5′-end RNA sequencing. found that epidermis contains more mRNA per total than controls took this into account in bioinformatic analysis. The approach highlighted innate immunity-related...
Objective: Skin graft donor site management is a concern particularly for elderly patients and with poor wound healing competence, also because sites are source of pain discomfort. Although different types dressings exist, there no consensus regarding optimal dressing type on care to promote healing, reduce pain, improve patients' comfort. Approach: This prospective, single-center clinical trial evaluated the performance nanofibrillar cellulose (NFC) (FibDex® by UPM-Kymmene Corporation)...
The purpose of this study was to establish the incidence and mortality burn patients with acute renal failure (ARF) at Helsinki Burn Centre analyze associated factors. files 238 intensive care (ICU) a total 1380 admitted our institution between November 1988 December 2001 were studied retrospectively. Of all patients, 17.2% needed ICU. According criteria (S-Cr >120 µmol/l = 1.4 mg/dl), 39.1% ICU suffered from ARF one in three these required replacement therapy. proportion requiring therapy...
Abstract Healing of the epidermis is a crucial process for maintaining skin's defense integrity and its resistance to environmental threats. Compromised wound healing renders individual readily vulnerable infections loss body homeostasis. To clarify human response reepithelialization, we biopsied split‐thickness skin graft donor site wounds immediately before after harvesting, as well during 3 7 days thereafter. In all, 25 biopsies from eight patients qualified study. All samples were...
Free flap surgery is routine today, yet little known of its pathophysiology. In this study, the authors evaluated hemodynamics in different types free microvascular flaps, by measuring intraoperative transit-time flow. Eighty-six transplants-21 TRAM flaps for breast reconstruction, 18 radial forearm head and neck reconstructions, 47 muscle neck, trunk lower extremity reconstructions-were studied. Donor artery flow was highest (mean: 57.5 ± 50 (SD) ml/min) but dropped (p < 0.001) to one tenth...
Clinical examination is still the gold standard of postoperative free flap monitoring, but with intraorally situated and/or buried flaps, it can be difficult or impossible. Microdialysis a sampling technique which offers possibility to monitor metabolism continuously. Ischemia detected by monitoring changes in glucose, lactate, and pyruvate levels interstitial fluid specific tissue. Our aim was use microdialysis flaps used for reconstructions inside oral cavity/oropharynx evaluate...
Background: Although wound contraction is an essential part of healing, excessive can compromise healing through induction scarring and fibrosis. This in turn leads to development contractures that limit elasticity function. Major research efforts have focused on novel therapeutic approaches gain inhibitory control over contraction. Despite these efforts, the need for cost-effective, clinically feasible, effective agents inhibit remains. Methods: In this study, authors investigated effect...
ABSTRACT We previously showed cell–cell contacts of human dermal fibroblasts to induce expression the hepatocyte growth factor/scatter factor (HGF) in a process designated as nemosis. Now we report on nemosis initiation bone marrow mesenchymal stem cells (BMSCs). Because BMSCs are being used increasingly cell transplantation therapy aimed demonstrate functional effect and benefit BMSC for wound healing. Nemotic monolayer were stimulate HaCaT keratinocyte migration scratch‐wound healing...
CCHCR1 (Coiled-Coil α-Helical Rod protein 1), within the major psoriasis susceptibility locus PSORS1, is a plausible candidate gene with associated risk allele CCHCR1*WWCC. Although its expression pattern in psoriatic skin differs from healthy and overexpression influences cell proliferation transgenic mice, role as effector has remained unsettled. The 5′-region of contains SNP (rs3130453) that controls 5′-extended open reading frame thus translation alternative isoforms. We have now...