A5057958511- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Fire effects on ecosystems
- Optimism, Hope, and Well-being
- Climate Change and Health Impacts
- Vector-Borne Animal Diseases
- Celiac Disease Research and Management
- Vector-borne infectious diseases
- Immune Cell Function and Interaction
- Regulation of Appetite and Obesity
- Renal Diseases and Glomerulopathies
- Parvovirus B19 Infection Studies
- Research in Social Sciences
- Organ Donation and Transplantation
- Dialysis and Renal Disease Management
- Autoimmune Bullous Skin Diseases
- Eosinophilic Esophagitis
- Biochemical Analysis and Sensing Techniques
- Microscopic Colitis
- Adolescent and Pediatric Healthcare
- Blood Pressure and Hypertension Studies
- Flood Risk Assessment and Management
- Neuropeptides and Animal Physiology
- Cardiovascular Health and Disease Prevention
- Biomarkers in Disease Mechanisms
Tampere University
2015-2024
Tampere University Hospital
2015-2024
University of Turku
2012-2023
Turku Centre for Biotechnology
2023
NHS Tayside
2019
Barro Colorado Island
2016
Varsinais-Suomen Sairaanhoitopiiri
2013
Coxa Hospital
2007-2009
Institute of Biochemistry
1999-2000
Comenius University Bratislava
1999-2000
The therapeutic potential of a novel, targeted-release formulation oral budesonide (Nefecon) for the treatment IgA nephropathy (IgAN) was first demonstrated by phase 2b NEFIGAN trial. To verify these findings, 3 NefigArd trial tested efficacy and safety nine months with Nefecon (16 mg/d) versus placebo in adult patients primary IgAN at risk progressing to kidney failure (ClinicalTrials.gov: NCT03643965). NefIgArd multicenter, randomized, double-blind, placebo-controlled two-part In Part A,...
Several plant estrogens, especially coumestrol and genistein, were found to reduce the conversion of [3H]estrone [3H] 17 beta-estradiol catalyzed by estrogen-specific beta-hydroxysteroid oxidoreductase Type 1 (E.C. 1.1.1.62) in vitro. Coumestrol, most potent inhibitor our experiments, is best enzyme known date. All compounds with inhibitory effects also estrogenic. However, structural demands for beta-HSOR inhibition estrogenicity tested breast cancer cells (judged increased cell...
Several flavonoids and isoflavonoids were found to inhibit 17beta-oxidoreduction of estrogens by the purified 17beta-HSOR type 1, or in cell lines expressing 1 enzyme (T-47D breast cancer cells) 2 (PC-3 prostate cells). The structural demands for inhibition estrone (E1) reduction estradiol (E2) oxidation catalyzed types 2, respectively, not identical. Flavones, flavanones, isoflavones hydroxylated at both double ring (positions 5 7) B (position 4') most potent inhibitors E1 T-47D cells,...
We describe a cluster of norovirus outbreaks affecting about 200 people in Southern Finland September and October 2009. All occurred after consumption imported raspberries from the same batch intended for catering sector. Human genotype GI.4 was found frozen raspberries. The berries were served toppings cakes separate settings or mixed curd cheese as snack children daycare center. relative risk berry dish 3.0 (p <or= 0.05) at centre. also detected samples two patients, berries. Both shared...
Nephropathia epidemica (NE) is a Scandinavian type of hemorrhagic fever with renal syndrome caused by Puumala hantavirus. The clinical course the disease varies greatly in severity. aim present study was to evaluate whether plasma C-reactive protein (CRP) and interleukin (IL)-6 levels associate severity NE. A prospectively collected cohort 118 consecutive hospital-treated patients acute serologically confirmed NE examined. Plasma IL-6, CRP, creatinine, as well blood cell count daily urinary...
Almost 3500 tick samples, originally collected via a nationwide citizen science campaign in 2015, were screened to reveal the prevalence and distribution of wide spectrum established putative tick-borne pathogens vectored by Ixodes ricinus I. persulcatus Finland. The unique geographical these two species Finland allowed us compare pathogen occurrence between an ricinus-dominated area (southern Finland), persulcatus-dominated (northern sympatric (central Finland). Of analysed ticks, almost...
The tumor necrosis factor (TNF)-alpha(-308) G/A polymorphism (TNF-2) is in linkage disequilibrium with the human leukocyte antigen (HLA)-B8-DR3 haplotype. Both factors have been associated severe Puumala hantavirus-induced nephropathia epidemica (NE). To examine which part of this extended haplotype might show strongest association outcome NE, HLA-B, HLA-DRB1, and TNF-alpha(-308) alleles 116 hospital-treated patients NE were analyzed. findings pointing to clinically strongly HLA-B8-DR3 There...
A patient with severe capillary leakage syndrome caused by a Puumala hantavirus infection was treated single dose of icatibant, bradykinin receptor antagonist, dramatic positive response. We suggest that this drug should be tested in larger number patients infection.
Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary (HCPS) in humans. Both diseases are considered to be immunologically mediated but the exact pathological mechanisms still poorly understood. Neutrophils first line of defense against invading microbes little is known their role virus infections. We wanted study neutrophils HFRS using blood tissue samples obtained from Puumala (PUUV)-infected patients. found that neutrophil activation products...
In 2015 a long-term, nationwide tick and tick-borne pathogen (TBP) monitoring project was started by the Finnish Tick Project Research Station network (RESTAT), with goal of producing temporally geographically extensive data regarding exophilic ticks in Finland. current study, we present results from first four years this collaboration. Ticks were collected cloth dragging 11 research stations across Finland May-September 2015-2018 (2012-2018 Seili). Collected screened for twelve different...
Abstract The induction and maintenance of T cell memory is incompletely understood, especially in humans. We have studied the response generation during acute infection by Puumala virus (PUUV), a hantavirus endemic to Europe. It causes self-limiting with no viral persistence, manifesting as hemorrhagic fever renal syndrome. HLA tetramer staining PBMC showed that CD8+ peaked at onset clinical disease decreased within next 3 wk. Expression activation markers on tetramer-positive cells was also...
Introduction. Hantaviruses are important human pathogens that cause clinical diseases characterized by renal and cardiopulmonary manifestations. Their pathogenesis is currently poorly understood. We have studied the role of complement system in Puumala (PUUV) hantavirus infection.
Abstract Most tick‐related studies in Europe have been conducted nonurban areas, but ticks and tick‐borne pathogens also occur urban green spaces. From a public health perspective, risks regarding infections should be studied these where contacts between infected humans may more frequent than elsewhere, due to high human activity. We examined the risk of encountering an tick spaces Helsinki, Finland. collected at nine sites throughout recorded prevalence several identified areas with...
The clinical outcome of Puumala hantavirus (PUUV) infection shows extensive variation, ranging from inapparent subclinical (70-80%) to severe hemorrhagic fever with renal syndrome (HFRS), about 0.1% cases being fatal. Most hospitalized patients experience acute kidney injury (AKI), histologically known as tubulointerstitial nephritis. Why this variation? There is no evidence that there would be more virulent and less variants infecting humans, although has not been extensively studied....
Puumala hantavirus (PUUV) infection, also known as nephropathia epidemica, is the most common cause of hemorrhagic fever with renal syndrome (HFRS) in Europe. The pathogenesis PUUV epidemica complex and multifactorial, risk factors for severe acute kidney injury (AKI) during infection are not well defined. We conducted a prospective study hospitalized patients Tampere, Finland to identify illness HFRS severity. Serial daily blood urine samples were collected throughout at 2 week 6 month...
Urokinase-type plasminogen activator receptor is a multifunctional glycoprotein, the expression of which increased during inflammation. It known to bind β3-integrins, are elementary for cellular entry hantaviruses. Plasma soluble form (suPAR) levels were evaluated as predictor severe Puumala hantavirus (PUUV) infection and possible factor involved in pathogenesis disease.A single-centre prospective cohort study.Plasma suPAR measured twice acute phase once convalescence 97 patients with...
<b><i>Background:</i></b> Puumala hantavirus (PUUV) induces an acute tubulointerstitial nephritis and kidney injury (AKI). Our aim was to evaluate the prognosis of severe AKI associated with PUUV infection. <b><i>Methods:</i></b> We examined 556 patients who were treated at Tampere University Hospital during 1982-2013 for acute, serologically confirmed Plasma creatinine measured hospitalization, convalescence, 1, 2, 5 years after...
The sheep tick Ixodes ricinus is the primary vector for various zoonotic diseases, including Lyme borreliosis and tick-borne encephalitis (TBE), in Europe. Because both abundance of ticks prevalence pathogens these organisms have increased many locations under different environments, we designed a study to survey occurrence an urban area, namely, city Turku, SW Finland. In summer 2017, collected >700 ticks, primarily from parks, suburban forest patches, recreational areas. Comprehensive...