Marijn M. Speeckaert
A5019072577- Chronic Kidney Disease and Diabetes
- Vitamin D Research Studies
- Vitamin C and Antioxidants Research
- COVID-19 Clinical Research Studies
- Advanced Glycation End Products research
- melanin and skin pigmentation
- Spectroscopy Techniques in Biomedical and Chemical Research
- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Hemoglobinopathies and Related Disorders
- Metabolomics and Mass Spectrometry Studies
- Iron Metabolism and Disorders
- SARS-CoV-2 and COVID-19 Research
- Blood Pressure and Hypertension Studies
- Diabetes Treatment and Management
- Hemoglobin structure and function
- Spectroscopy and Chemometric Analyses
- Neonatal Health and Biochemistry
- Pediatric Urology and Nephrology Studies
- Urinary Tract Infections Management
- Hormonal Regulation and Hypertension
- Atherosclerosis and Cardiovascular Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Clinical Laboratory Practices and Quality Control
- Dermatologic Treatments and Research
Ghent University Hospital
2016-2025
Research Foundation - Flanders
2019-2025
Ghent University
2011-2024
John Wiley & Sons (United States)
2019
John Wiley & Sons (United Kingdom)
2019
Oxfam
2019
Hudson Institute
2019
Pediatric Nephrology of Alabama
2016
In 1886, Max Jaffe discovered a reaction of creatinine with picric acid in an alkaline environment. Although the manuscript describes nature precipitate and does not deal analytical assay, Jaffe's landmark paper elucidated basic principles determination method (originally developed by Otto Folin), which became immensely popular has easily withstood test time. Despite advent enzymatic analysis, is still due to its simplicity low cost. As there no standard recipe for 'Jaffe' method, much...
Chronic kidney disease (CKD) is characterized by accumulation of protein-bound uremic toxins such as p-cresyl sulfate, glucuronide, indoxyl sulfate and indole-3-acetic acid, which originate in the gut. Intestinal bacteria metabolize aromatic amino acids into p-cresol indole, (further conjugated colon mucosa liver) acid. Here we measured fecal, plasma urine metabolite concentrations; contribution gut bacterial generation to accumulation; influx circulating at different stages CKD. Feces,...
The therapeutic potential of a novel, targeted-release formulation oral budesonide (Nefecon) for the treatment IgA nephropathy (IgAN) was first demonstrated by phase 2b NEFIGAN trial. To verify these findings, 3 NefigArd trial tested efficacy and safety nine months with Nefecon (16 mg/d) versus placebo in adult patients primary IgAN at risk progressing to kidney failure (ClinicalTrials.gov: NCT03643965). NefIgArd multicenter, randomized, double-blind, placebo-controlled two-part In Part A,...
Finerenone reduced the risk of kidney and cardiovascular events in people with chronic disease (CKD) type 2 diabetes FIDELIO-DKD FIGARO-DKD phase 3 studies. Effects finerenone on outcomes patients taking sodium-glucose cotransporter inhibitors (SGLT2is) were evaluated a prespecified pooled analysis these studies.Patients urine albumin-to-creatinine ratio (UACR) ≥30 to ≤5,000 mg/g estimated glomerular filtration rate (eGFR) ≥25 mL/min/1.73 m2 randomly assigned or placebo; SGLT2is permitted at...
ABSTRACT Background Finerenone, a non-steroidal mineralocorticoid receptor antagonist, improved kidney and cardiovascular outcomes in patients with chronic disease (CKD) type 2 diabetes two phase 3 outcome trials. The addition to standard of care, on the progression Non-Diabetic Chronic Kidney Disease (FIND-CKD) study investigates effect finerenone adults CKD without diabetes. Methods FIND-CKD (NCT05047263 EU CT 2023-506897-11-00) is randomized, double-blind, placebo-controlled trial...
To the Editor,The outbreak of COVID-19 pandemic shows a marked geographical variation in its prevalence and mortality.As no viral mutations have been reported, which can explain important variations, question arises if genetic host may affect outcome infection.We therefore postulated that variability genotype distribution number immune-related human plasma proteins showing [1-3] might partly variable infection.Prevalence mortality data (per 1,000,000 inhabitants) infection from European,...
The emergence of artificial intelligence and machine learning (ML) has revolutionized the landscape clinical medicine, offering opportunities to improve medical practice research. This narrative review explores current status prospects applying ML chronic kidney disease (CKD). ML, at intersection statistics computer science, enables computers derive insights from extensive datasets, thereby presenting an interesting for constructing statistical models improving data interpretation....