A5088555176- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Vestibular and auditory disorders
- Neurobiology and Insect Physiology Research
- Olfactory and Sensory Function Studies
- Genetic Neurodegenerative Diseases
- Neuroscience of respiration and sleep
- Hearing, Cochlea, Tinnitus, Genetics
- Cellular transport and secretion
- Advanced MRI Techniques and Applications
- Long-Term Effects of COVID-19
- Circadian rhythm and melatonin
- Restless Legs Syndrome Research
- Neural Networks and Applications
- Autism Spectrum Disorder Research
- Neural dynamics and brain function
- Transcranial Magnetic Stimulation Studies
- Axon Guidance and Neuronal Signaling
- Memory and Neural Mechanisms
- Mitochondrial Function and Pathology
- Advanced Neuroimaging Techniques and Applications
- Neurogenesis and neuroplasticity mechanisms
- Biochemical Analysis and Sensing Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
NYU Langone Health
2022-2023
Neurosciences Institute
2021-2022
New York University
2022
Columbia University
2011-2020
Howard Hughes Medical Institute
2011
Northwestern University
2003-2008
Alpha-synuclein seed amplification assays (αSyn-SAAs) are promising diagnostic tools for Parkinson's disease (PD) and related synucleinopathies. They enable detection of seeding-competent alpha-synuclein aggregates in living patients have shown high accuracy several PD other synucleinopathy patient cohorts. However, there has been confusion about αSyn-SAAs their methodology, nomenclature, relative accuracies when performed by various laboratories. We compared αSyn-SAA results obtained from...
Neuronal firing patterns are determined by the cell's intrinsic electrical and morphological properties regulated synaptic interactions. While of cerebellar neurons have generally been studied in much detail, little is known about unipolar brush cells (UBCs), a type glutamatergic interneuron that enriched granular layer mammalian vestibulocerebellum participates representation head orientation space. Here we show UBCs can be distinguished from adjacent granule on basis differences membrane...
Neuronal firing is regulated by the complex interaction of multiple depolarizing and hyperpolarizing currents; intrinsic firing, which defines neuronal ability to generate action potentials in absence synaptic excitation, particularly sensitive modulation currents that are active below potential threshold. Cerebellar unipolar brush cells (UBCs) excitatory granule layer interneurons capable firing; here we show that, acute mouse cerebellar slices, barium-sensitive background potassium...
Odors activate distributed ensembles of neurons within the piriform cortex, forming cortical representations odor thought to be essential olfactory learning and behaviors. This response is driven by direct input from bulb, but also shaped a dense network associative or intracortical inputs piriform, which may enhance constrain representation. With optogenetic techniques, it possible functionally isolate defined cortex assess their potential inhibit pyramidal neurons. The anterior nucleus...
Abstract Non-motor symptoms of Parkinson’s disease (PD) such as dysautonomia and REM sleep behavior disorder (RBD) are recognized to be important prodromal that may also indicate clinical subtypes PD with different pathogenesis. Unbiased clustering analyses showed subjects RBD symptoms, well early cognitive dysfunction, have faster progression the disease. Through analysis Progression Markers Initiative (PPMI) de novo cohort, we tested hypothesis RBD, which readily assessed by standard...