A5041943164- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Neurogenesis and neuroplasticity mechanisms
- Ion Channels and Receptors
- Sleep and Wakefulness Research
- Pain Mechanisms and Treatments
- Ion channel regulation and function
- Neuroinflammation and Neurodegeneration Mechanisms
- Vestibular and auditory disorders
- Olfactory and Sensory Function Studies
- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Pain Management and Placebo Effect
- Hearing, Cochlea, Tinnitus, Genetics
- Axon Guidance and Neuronal Signaling
- Ubiquitin and proteasome pathways
- Neural and Behavioral Psychology Studies
- Neuropeptides and Animal Physiology
- Primate Behavior and Ecology
- Musculoskeletal pain and rehabilitation
- Photoreceptor and optogenetics research
- Neurobiology and Insect Physiology Research
National Taiwan University
2016-2023
Academia Sinica
2023
National Institute on Drug Abuse
2013-2017
National Institutes of Health
2013-2015
Czech Academy of Sciences, Institute of Physiology
2013
Northwestern University
2008-2011
National Yang Ming Chiao Tung University
2003-2008
Neuropathic pain is a chronic that results from lesion or dysfunction of the nervous system. Depression and cognitive decline are often coupled to pain, suggesting involvement cortical areas associated with higher functions. We investigated layer 2/3 pyramidal neurons in acute slices contralateral medial prefrontal cortex (mPFC) rat spared nerve injury (SNI) model neuropathic found morphological functional differences between mPFC SNI sham-operated animals. Basal, but not apical, dendrites...
The receptor tyrosine kinases represent an important class of signal transduction molecules that have been shown to play critical roles in neural development. We report the present study neuregulin ErbB4 is preferentially expressed by interneurons are migrating tangentially from ventral dorsal rat telencephalon. immunoreactivity was detected medial ganglionic eminence as early embryonic day (E) 13 at inception tangential migration. Prominent ErbB4-positive migratory streams consisting cells...
Summary IL-1β expression in the contralateral hippocampus coincides with neuropathic pain behavior rats, and correlations between hippocampal IL-1ra or IL-6 are lost. We have proposed that engages emotional learning, suggesting involvement of hippocampus. Because cytokines periphery contribute to induction maintenance but might also participate centrally, we used 2 models, chronic constriction injury (CCI) spared nerve (SNI), investigate temporal profile cytokine gene rat strains show...
Relapse to maladaptive eating habits during dieting is often provoked by stress. Recently, we identified a role of dorsal medial prefrontal cortex (mPFC) neurons in stress-induced reinstatement palatable food seeking male rats. It unknown whether endogenous neural activity mPFC drives female Here, used an optogenetic approach, which rats received bilateral microinjections viral constructs coding light-sensitive eNpHR3.0–eYFP or control eYFP protein and intracranial fiber optic implants. Rats...
Febrile seizures are associated with increased brain temperature and often resistant to treatments antiepileptic drugs, such as carbamazepine phenytoin, which sodium channel blockers. Although they clearly correlated the hyperthermic condition, precise cellular mechanisms of febrile remain unclear. We performed patch-clamp recordings from pyramidal cells in acute rat slices at temperatures up 40°C found that, ≥37°C, L-type calcium channels active unexpectedly hyperpolarized potentials drive...
The electrophysiological phenotype of individual neurons critically depends on the biophysical properties voltage-gated channels they express. Differences in sodium channel gating are instrumental determining different firing phenotypes pyramidal cells and interneurons; moreover, modulation represents an important mechanism action for many widely used CNS drugs. Flufenamic acid (FFA) is a non-steroidal anti-inflammatory drug that has been long as blocker calcium-dependent cationic...
The locus coeruleus (LC) contains noradrenergic (NA) neurons that respond to novel stimuli in the environment with phasic activation initiate an orienting response; LC is also triggered by stimuli, representing outcome of task-related decision processes, facilitate ensuing behaviours and help optimize task performance. Here, we report LC-NA exhibit bursts action potentials vitro resembling vivo, activity gated inhibitory interneurons (I-INs) located peri-LC. We observe inhibition peri-LC...
The ventral tegmental area (VTA) receives phenotypically distinct innervations from the pedunculopontine nucleus (PPTg). While PPTg-to-VTA inputs are thought to play a critical role in stimulus-reward learning, direct evidence linking learning process remains lacking. Here, we used optogenetic approaches investigate functional contribution of PPTg excitatory and inhibitory VTA appetitive Pavlovian conditioning. We show that photoinhibition cholinergic or glutamatergic during cue presentation...
We herein provide a thorough description of new transgenic mouse models for dentatorubral-pallidoluysian atrophy (DRPLA) harboring single copy the full-length human mutant DRPLA gene with 76 and 129 CAG repeats. The Q129 line was unexpectedly obtained by en masse expansion based on somatic instability repeats in vivo. mRNA expression levels both Q76 transgenes were each 80% that endogenous gene, whereas only mice exhibited devastating progressive neurological phenotypes similar to those...
Neuronal firing is regulated by the complex interaction of multiple depolarizing and hyperpolarizing currents; intrinsic firing, which defines neuronal ability to generate action potentials in absence synaptic excitation, particularly sensitive modulation currents that are active below potential threshold. Cerebellar unipolar brush cells (UBCs) excitatory granule layer interneurons capable firing; here we show that, acute mouse cerebellar slices, barium-sensitive background potassium...
The parabrachial nucleus (PBN) interfaces between taste and feeding systems is also an important hub for relaying distress information threats. Despite that the PBN sends projections to ventral tegmental area (VTA), a heterogeneous brain region regulates motivational behaviors, function of PBN-to-VTA connection remains elusive. Here, by using male mice in several behavioral paradigms, we discover VTA-projecting neurons are significantly engaged contextual fear, restraint or mild stress but...
Long-term potentiation (LTP) is well recognized as a cellular-correlated synaptic plasticity of learning and memory. However, its reversal forms plasticity, depotentiation, less studied association with behaviors also far from clear. Previously, we have shown that nanomolar orexin A can prevent the depotentiation induced by low frequency stimulation (LFS) following theta burst stimulation-induced LTP, namely inducing re-potentiation, at hippocampal CA1 synapses in vitro. Here, explored...
Abstract Recent studies have shown that the non‐DA neurons in ventral tegmental area (VTA) and substantia nigra (SN) not only modulate motivational behaviors but also regulate defensive behaviors. While zona incerta (ZI) is a threat‐responsive substrate receives innervations from midbrain, function of midbrain‐to‐ZI connection remains poorly defined. Here, we demonstrate ZI heterogenous midbrain. By utilizing retrograde AAV preferentially labeling found ZI‐projecting cells midbrain are...