A5114256608- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Adrenal Hormones and Disorders
- Neuropeptides and Animal Physiology
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Vagus Nerve Stimulation Research
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- Trypanosoma species research and implications
- Neuroscience and Neuropharmacology Research
- Research on Leishmaniasis Studies
- Pharmacological Effects of Natural Compounds
- Cancer, Stress, Anesthesia, and Immune Response
- Adipokines, Inflammation, and Metabolic Diseases
- Cytokine Signaling Pathways and Interactions
- Pain Mechanisms and Treatments
- Biochemical Analysis and Sensing Techniques
- Monoclonal and Polyclonal Antibodies Research
- Growth Hormone and Insulin-like Growth Factors
- Circadian rhythm and melatonin
- T-cell and B-cell Immunology
- Regulation of Appetite and Obesity
Philipps University of Marburg
2015-2024
Czech Academy of Sciences, Institute of Physiology
2009-2021
Universidad Nacional Autónoma de México
2021
Secretaria de Salud
2021
Institut für Grenzgebiete der Psychologie und Psychohygiene
2006-2007
University Hospital Regensburg
2005
Institute of Normal and Pathological Physiology of the Slovak Academy of Sciences
2003
Hamamatsu University School of Medicine
1998
University of Amsterdam
1991
University Hospital of Basel
1989-1991
The production and action of immunoregulatory cytokines, including interleukin-1 (IL-1), are inhibited by glucocorticoid hormones in vivo vitro. Conversely, blood levels were increased factors released human leukocytes exposed to Newcastle disease virus preparations. This activity was neutralized an antibody IL-1. Therefore the capacity IL-1 stimulate pituitary-adrenal axis tested. Administration subpyrogenic doses homogeneous monocyte-derived or p I 7 form recombinant mice rats...
Intraperitoneal administration of human recombinant interleukin-1 (IL-1) to rats can increase blood levels corticosterone and adrenocorticotropic hormone (ACTH). The route by which IL-1 affects pituitary-adrenal activity is unknown. That the IL-1-induced activation involves an increased secretion corticotropin-releasing factor (CRF) indicated three lines evidence. First, immunoneutralization CRF markedly attenuated ACTH levels. Second, after blockade fast axonal transport in hypothalamic...
A decreased noradrenaline turnover in the hypothalami of rats was observed at peak immune response to sheep red blood cells. The decrease noradrenergic neuronal activity mimicked by injection soluble r mediators released immunological cells activated vitro. Noradrenaline also tended brainstem but not residual brain. It is suggested that products from during may induce previously described autonomic and endocrine mechanisms contribute immunoregulation.
The immune system is subject to an array of identified autoregulatory processes, but immunoregulation may also have a further basis in network immune-neuroendocrine interactions. Two antigens each produced increase more than 100% electrical activity individual neurones the ventromedial not anterior nucleus rat hypothalamus. Animals that failed respond antigen manifested no firing rate. These findings constitute first evidence for flow information from activated hypothalamus, suggesting brain...
SummaryInjection of three different antigens into rats or mice led in the course several days to about a threefold increase serum corticosterone levels and concommitantly decrease thyroxine (rats). In view known immuno-suppressive effect glucocorticoids possibility is considered that endocrine changes induced during immune response could significantly modulate subsequent character response, e.i. magnitude, duration lymphoid cell proliferation, however, more complete pattern hormonal...
Microglial activation has been associated with the pathogenesis of Parkinson's disease (PD). Among many components this reaction, cytokines have proposed as candidates to mediate neurodegenerative or neuroprotective effects. We investigated interleukin-1 system and tumour necrosis factor-alpha mRNA protein levels at different time intervals in subacute intrastriatal 6-hydroxydopamine rat model PD, parallel inflammatory response. Immunohistochemistry showed that microglial cells were...
The regional distribution and inducibility of cytokines in the normal brain is still a matter controversy. As an attempt to clarify this issue, we studied constitutive induced expression interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma mRNAs brain, pituitary, spleen mice using qualitative semiquantitative reverse-transcription polymerase chain reaction. contribution nonbrain cells cytokine transcripts detected was considered. With exception IFN-gamma...
I. Introduction THE existence of mechanisms that provide immunity to an infective agent was inferred from empirical observations obtained through the ingenuity and deductive capacity early investigators. The first procedures for vaccinations serotherapy resulted these observations. implementation procedures, probably most important contribution immunology medical science, was, at first, based on a very rudimentary knowledge immune system. During half 20th century, this rather primitive...
Effects on turnover of vasopressin (AVP) in the hypothalamus and secretion pituitary hormones, catecholamines insulin after intraperitoneal injection recombinant interleukin-1 (beta) (IL-1) were investigated male wistar rats. Intraper-itoneal administration IL-1 a dose (1 µg) that maximally activated pituitary-adrenal activity failed to alter plasma concentrations prolactin, luteinizing hormone melanocyte-stimulating hormone. Rats chronically cannulated right jugular veins showed...
Summary IL-1β expression in the contralateral hippocampus coincides with neuropathic pain behavior rats, and correlations between hippocampal IL-1ra or IL-6 are lost. We have proposed that engages emotional learning, suggesting involvement of hippocampus. Because cytokines periphery contribute to induction maintenance but might also participate centrally, we used 2 models, chronic constriction injury (CCI) spared nerve (SNI), investigate temporal profile cytokine gene rat strains show...
Neuroinflammation (NI) is a key feature in the pathogenesis and progression of infectious non-infectious neuropathologies, its amelioration usually improves patient outcome. Peripheral inflammation may promote NI through microglia astrocytes activation, an increased expression inflammatory mediators vascular permeability that lead to neurodegeneration. Several anti-inflammatory strategies have been proposed control peripheral inflammation. Among them, electrical stimulation vagus nerve (VNS)...
Alterations in glucose metabolism are known to occur during certain types of inflammation and infectious diseases. Interleukin 1 (IL 1), an immune-derived cytokine released these processes, is proposed function as a mediator such alterations, since administration low subpyrogenic doses human rIL mice rats produced hypoglycemia. In this effect was paralleled by increased insulin, glucagon, corticosterone blood levels. When IL repeatedly injected, remained hypoglycemic for at least 14 h after...