A5026967768- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Regulation of Appetite and Obesity
- Stress Responses and Cortisol
- Photoreceptor and optogenetics research
- Substance Abuse Treatment and Outcomes
- Obsessive-Compulsive Spectrum Disorders
- Cannabis and Cannabinoid Research
- Biochemical Analysis and Sensing Techniques
Oregon Health & Science University
2021-2025
University of Michigan
2016-2023
National Institutes of Health
2013
National Institute on Drug Abuse
2013
Drug self-administration models of addiction typically require animals to make the same response (e.g., a lever-press or nose-poke) over and procure take drugs. By their design, such procedures often produce behavior controlled by stimulus-response (S-R) habits. This has supported notion as "drug habit," led considerable advances in our understanding neurobiological basis behavior. However, drugs cocaine, addicts ingenuity flexibility seeking behavior, which, definition, precludes...
Relapse to maladaptive eating habits during dieting is often provoked by stress. Recently, we identified a role of dorsal medial prefrontal cortex (mPFC) neurons in stress-induced reinstatement palatable food seeking male rats. It unknown whether endogenous neural activity mPFC drives female Here, used an optogenetic approach, which rats received bilateral microinjections viral constructs coding light-sensitive eNpHR3.0–eYFP or control eYFP protein and intracranial fiber optic implants. Rats...
The temporal pattern of drug use (pharmacokinetics) has a profound effect on the ability self-administered cocaine to produce addiction-like behavior in rodents, and change brain. To further address this issue, we compared effects long access (LgA) self-administration, which is widely used model transition addiction, with intermittent (IntA), thought better reflect humans, single, injection increase dopamine (DA) overflow core nucleus accumbens (using vivo microdialysis), behavior. IntA...
Relapse represents a consistent clinical problem for individuals with substance use disorder. In the incubation of craving model persistent and relapse, cue-induced drug seeking progressively intensifies or 'incubates' during first weeks abstinence from self-administration then remains high months. Previously, we others have demonstrated that expression incubated cocaine requires strengthening excitatory synaptic transmission in nucleus accumbens core (NAcc). However, despite importance...
Abstract Relapse is a major challenge to the treatment of substance use disorders. A progressive increase in cue-induced drug craving, termed incubation observed after withdrawal from multiple drugs abuse humans and rodents. Incubation cocaine craving involves strengthening excitatory synapses onto nucleus accumbens (NAc) medium spiny neurons via postsynaptic accumulation high-conductance Ca 2+ -permeable AMPA receptors. This enhances reactivity drug-associated cues required for expression...
Recent studies suggest that the temporal pattern of drug use (pharmacokinetics) has a profound effect on ability self-administered cocaine to produce addiction-like behavior in rodents, and change brain. To further address this issue, we compared effects Long Access (LgA) self-administration, which is widely used model transition addiction, with Intermittent (IntA), thought better reflect humans, increase dopamine (DA) overflow core nucleus accumbens (using vivo microdialysis), behavior....
Abstract Rationale Compared to obesity-resistant rats, obesity-prone rats consume more food, work harder obtain show greater motivational responses food-cues, and striatal plasticity in response eating sugary/fatty foods. Therefore, it is possible that may also be sensitive the properties of cocaine cocaine-paired cues, induced by cocaine. Objective To examine baseline differences motivation for effects intermittent access (IntA) self-administration on motivation, neurobehavioral...
Abstract In the ‘incubation of cocaine craving’ model relapse, rats exhibit progressive intensification (incubation) cue-induced craving over several weeks forced abstinence from self-administration. The expression incubated depends on plasticity excitatory synaptic transmission in nucleus accumbens core (NAcC) medium spiny neurons (MSN). Previously, we found that maintenance this and incubation ongoing protein translation, regulation translation is altered after craving. Here used male...