A5012194117- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Glaucoma and retinal disorders
- Photoreceptor and optogenetics research
- Total Knee Arthroplasty Outcomes
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Olfactory and Sensory Function Studies
- Functional Brain Connectivity Studies
- Retinal and Optic Conditions
- Retinal Diseases and Treatments
- Psychedelics and Drug Studies
- Psychosomatic Disorders and Their Treatments
- Orthopaedic implants and arthroplasty
- Mental Health Treatment and Access
- Neurogenesis and neuroplasticity mechanisms
- Elder Abuse and Neglect
- Neuroinflammation and Neurodegeneration Mechanisms
- Retinal Development and Disorders
- Glycogen Storage Diseases and Myoclonus
- Healthcare Decision-Making and Restraints
- Obsessive-Compulsive Spectrum Disorders
Columbia University
2013-2024
New York Psychoanalytic Society and Institute
2015-2024
New York State Psychiatric Institute
2015-2024
Icahn School of Medicine at Mount Sinai
2023
University of Pittsburgh at Bradford
2023
Columbia University Irving Medical Center
2017-2022
Research Foundation For Mental Hygiene
2021
University of California, Los Angeles
2021
Monash Health
2017
Cornell University
2011-2012
Fear conditioning has received extensive experimental attention. However, little is known about the molecular mechanisms that underlie fear memory consolidation. Previous studies have shown long-term potentiation (LTP) exists in pathways to be relevant and modifies neural processing these a manner similar LTP induction. The present experiments examined whether inhibition of protein synthesis, PKA, MAP kinase activity, treatments block LTP, also interfere with consolidation conditioning. Rats...
N ‐methyl‐ d ‐aspartate receptor (NMDAR) activation can trigger both long‐ and short‐term plasticity, promote cell survival, initiate death. A number of studies suggest that the consequences NMDAR vary widely depending on whether synaptic or extrasynaptic receptors are activated. Here we have examined spatial distribution NMDARs CA1 pyramidal neurons in acutely dissected hippocampal slices. Using a physiological definition as those not accessible to single release events, find comprise...
Decreased pleasure-seeking (anhedonia) forms a core symptom of depression. Stressful experiences precipitate depression and disrupt reward-seeking, but it remains unclear how stress causes anhedonia. We recorded simultaneous neural activity across limbic brain areas as mice underwent discovered stress-induced 4 Hz oscillation in the nucleus accumbens (NAc) that predicts degree subsequent blunted reward-seeking. Surprisingly, while previous studies on reward-seeking focused dopamine (DA)...
In their seminal findings, Hubel and Wiesel identified sensitive periods in which experience can exert lasting effects on adult visual cortical functioning behavior via transient changes neuronal activity during development. Whether comparable exist for non-sensory cortices, such as the prefrontal cortex, alterations determine circuit function is still an active area of research. Here, using mice we demonstrate that inhibition parvalbumin (PV)-expressing interneurons juvenile adolescent...
The maintenance of long-term potentiation (LTP) in the CA1 region hippocampus has been reported to require both a persistent increase phosphorylation and synthesis new proteins. increased activity protein kinase C (PKC) during phase LTP may result from formation PKMzeta, constitutively active fragment specific PKC isozyme. To define relationship among EPSP responses, requirement for synthesis, we examined regulation PKMzeta after sub-threshold stimulation that produced short-term (STP)...
<h3>BACKGROUND/AIMS</h3> Autoregulation of blood flow during posture change is important to ensure consistent organ circulation. The purpose this study was compare the in retrobulbar ocular glaucoma patients with normal subjects supine and upright posture. <h3>METHODS</h3> 20 open angle subjects, similar age sex distribution, were evaluated. Blood pressure, intraocular velocity tested after 30 minutes sitting again lying. Retrobulbar haemodynamic measures peak systolic (PSV), end diastolic...
N-Methyl-d-aspartate receptor (NMDAR) activation may promote cell survival or initiate death, with the outcome dependent on whether synaptic extrasynaptic receptors are activated. Similarly, this differential has been proposed to govern direction of plasticity. However, physiological parameters necessary activate NMDARs in brain slices remain unknown. Using irreversible use-dependent NMDAR antagonist MK-801 isolate NMDARs, we have tested ability short-stimulation trains from 5 400 Hz these...
To validate the first non-invasive measurements of volumetric ophthalmic artery blood flow in humans.The arteries healthy normal adults were examined by Advanced Technology Laboratories (ATL, a subsidiary Phillips Medical Systems Inc) high definition imaging (HDI) 5000 colour Doppler ultrasound with 5-12 MHZ probe. A group 14 subjects for experiment 1 and 10 experiments 2 3 selected, eye chosen randomly. Peak systolic velocities (PSV) end diastolic (EDV) central retinal measured recorded....