A5045546919- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Sex and Gender in Healthcare
- Neuroscience and Neuropharmacology Research
- Estrogen and related hormone effects
- Animal testing and alternatives
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Neurogenesis and neuroplasticity mechanisms
- Neural dynamics and brain function
- Menopause: Health Impacts and Treatments
- Science, Research, and Medicine
- Evolutionary Psychology and Human Behavior
- Circadian rhythm and melatonin
- Biochemical effects in animals
- Attachment and Relationship Dynamics
- Information and Cyber Security
- Anesthesia and Neurotoxicity Research
- Cannabis and Cannabinoid Research
- Birth, Development, and Health
- Mosquito-borne diseases and control
- Systemic Sclerosis and Related Diseases
- Axon Guidance and Neuronal Signaling
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Northeastern University
2016-2025
Universidad del Noreste
2020-2024
New York State Psychiatric Institute
2018-2023
Columbia University
2018-2023
New York Psychoanalytic Society and Institute
2023
University of Pittsburgh at Bradford
2023
Icahn School of Medicine at Mount Sinai
2008-2023
Boston University
2013-2015
Yale University
2003-2006
Traditional rodent models of Pavlovian fear conditioning assess the strength learning by quantifying freezing responses. However, sole reliance on this measure includes de facto assumption that any locomotor activity reflects an absence fear. Consequently, alternative expressions associative are rarely considered. Here we identify a novel, active response ('darting') occurs primarily in female rats. In females, darting exhibits characteristics learned behavior, appearing during CS period as...
Outdated gender stereotypes are influencing experimental design in laboratory animals
The recently implemented National Institutes of Health policy requiring that grant applicants consider sex as a biological variable in the design basic and preclinical animal research studies has prompted considerable discussion within neuroscience community. Here, we present reasons to be optimistic this new will valuable for neuroscience, suggest some ways neuroscientists think about incorporating their research.
Behavior is shaped by both the internal state of an animal and its individual behavioral biases. Rhythmic variation in gonadal hormones during estrous cycle a defining feature female state, one that regulates many aspects sociosexual behavior. However, it remains unclear whether influences spontaneous behavior and, if so, how these effects might relate to variation. Here, we address this question longitudinally characterizing open-field mice across different phases cycle, using unsupervised...
Chronic stress exposure has been reported to induce dendritic remodeling in several brain regions, but it is not known whether individual neural circuits show distinct patterns of remodeling. The current study tested the hypothesis that projections from infralimbic (IL) area medial prefrontal cortex (mPFC) basolateral nucleus amygdala (BLA), a pathway relevant stress-related mental illnesses like depression and post-traumatic disorder, would have unique pattern response chronic stress....
MINI REVIEW article Front. Hum. Neurosci., 05 April 2013Sec. Brain Health and Clinical Neuroscience Volume 7 - 2013 | https://doi.org/10.3389/fnhum.2013.00123
We have recently reported in male rats that medial prefrontal cortex (mPFC) neurons project to the basolateral nucleus of amygdala (BLA) are resilient stress-induced dendritic remodeling. The present study investigated whether this also occurs female rats. This pathway was identified using retrograde tracer Fast Blue injected into BLA ovariectomized with estrogen replacement (OVX + E) and without veh). Animals were exposed for 10 days either 2-h immobilization stress or home cage rest, after...
PTSD occurs in only a small fraction of trauma-exposed individuals, but risk is twice as high women men. The neurobiological basis for this discrepancy not known, the identification biological determinants resilience and susceptibility each sex could lead to more targeted preventions treatments. Animal models are useful tool dissecting circuits mechanisms that underlie brain's response stress, vast majority work has been developed conducted males. limited does incorporate female animals...
Symptoms of trauma and stressor related disorders such as post-traumatic stress disorder (PTSD) often develop well after the traumatic experience has occurred, so identifying early predictors risk or resilience is important for implementation interventional therapies. For example, passive coping strategies tonic immobility peritraumatic dissociation during itself are factors developments PTSD, especially in women. However, discrete, sex-specific responses that predict later outcomes animal...
Pavlovian fear conditioning is a widely used behavioral paradigm for studying associative learning in rodents. Despite early recognition that subjects may engage variety of both conditioned and unconditioned responses, the last several decades have seen field narrow its focus to measure freezing as sole indicator fear. We previously reported female rats were more likely than males darting, an escape-like response associated with heightened shock reactivity. To determine how experimental...
Women are twice as likely men to develop post-traumatic stress disorder (PTSD) making the search for biological mechanisms underlying these gender disparities especially crucial. One of hallmark symptoms PTSD is an alteration in ability extinguish fear responses trauma-associated cues. In male rodents, endocannabinoid system can modulate extinction and has been suggested a therapeutic target PTSD. However, whether how may expression females remains unknown.
Restraint stress has been shown to elicit numerous effects on hippocampal function and neuronal morphology, as well induce dendritic remodeling in the prefrontal cortex (PFC). However, of acute restraint PFC cognitive have not investigated, despite substantial evidence that malfunctions many stress-related disorders.The present study examined both male rats cycling female either proestrus (high estrogen) or estrus (low phase cycle. Animals were restrained for 60 120 minutes then tested...