A5041442122- Obsessive-Compulsive Spectrum Disorders
- Eating Disorders and Behaviors
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Autism Spectrum Disorder Research
- Body Image and Dysmorphia Studies
- Mental Health and Psychiatry
- Sexuality, Behavior, and Technology
- Attention Deficit Hyperactivity Disorder
- Neurotransmitter Receptor Influence on Behavior
- Treatment of Major Depression
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Child and Adolescent Psychosocial and Emotional Development
- Schizophrenia research and treatment
- Behavioral and Psychological Studies
- Transcranial Magnetic Stimulation Studies
- Advanced Neuroimaging Techniques and Applications
- Impact of Technology on Adolescents
- Child Abuse and Trauma
- Regional Development and Policy
- Botulinum Toxin and Related Neurological Disorders
- Pregnancy and preeclampsia studies
- Mental Health Research Topics
- Intimate Partner and Family Violence
- Homelessness and Social Issues
Columbia University Irving Medical Center
2016-2025
University of Minnesota Medical Center
2025
Columbia University
2015-2024
New York State Psychiatric Institute
2015-2024
New York Psychoanalytic Society and Institute
2014-2024
University of Wollongong
2017-2024
University of Minnesota System
2024
Pfizer (United States)
2024
International Rescue Committee
2021-2023
New York State Office of Mental Health
2014-2023
The purpose of the study was to test relative and combined efficacy clomipramine exposure ritual prevention in treatment obsessive-compulsive disorder (OCD) adults. Serotonin reuptake inhibitors (SRIs) cognitive behavior therapy by are both established treatments for OCD, yet their have not been demonstrated conclusively.A double-blind, randomized, placebo-controlled trial comparing prevention, clomipramine, combination (exposure plus clomipramine), pill placebo conducted at one center...
Although cortico-striato-thalamo-cortical (CSTC) circuit dysregulation is correlated with obsessive compulsive disorder (OCD), causation cannot be tested in humans. We used optogenetics mice to simulate CSTC hyperactivation observed OCD patients. Whereas acute orbitofrontal cortex (OFC)-ventromedial striatum (VMS) stimulation did not produce repetitive behaviors, repeated over multiple days generated a progressive increase grooming, mouse behavior related OCD. Increased grooming persisted...
In open trials, 1-Hz repetitive transcranial magnetic stimulation (rTMS) to the supplementary motor area (SMA) improved symptoms and normalized cortical hyper-excitability of patients with obsessive–compulsive disorder (OCD). Here we present results a randomized sham-controlled double-blind study. Medication-resistant OCD (n=21) were assigned 4 wk either active or sham rTMS SMA bilaterally. parameters consisted 1200 pulses/d, at 1 Hz 100% threshold (MT). Eighteen completed Response treatment...
Obsessive-compulsive disorder (OCD) is one of the world's most disabling illnesses according to World Health Organization. Serotonin reuptake inhibitors (SRIs) are only medications approved by Food and Drug Administration treat OCD, but few patients achieve minimal symptoms from an SRI alone. In such cases, practice guidelines recommend adding antipsychotics or cognitive-behavioral therapy consisting exposure ritual prevention (EX/RP).To compare effects these 2 augmentation strategies vs...
Objective: Although serotonin reuptake inhibitors (SRIs) are approved for the treatment of obsessive-compulsive disorder (OCD), most OCD patients who have received an adequate SRI trial continue to clinically significant symptoms. The purpose this study was examine effects augmenting SRIs with exposure and ritual prevention, established cognitive-behavioral therapy (CBT) OCD. Method: A randomized, controlled conducted at two academic outpatient clinics compare prevention versus stress...
Several studies have demonstrated that obsessive-compulsive disorder (OCD) is associated with interference in quality of life (QOL) and functional impairment. However, these did not compare individuals remission to who continue the disorder, predominantly used comparisons norms a matched normal sample, always consider impact comorbidity.We administered multiple measures assess QOL impairment 66 OCD patients had previously consented for clinical trial 36 age sex denied any psychiatric...
To investigate rates of response and remission in adults with obsessive-compulsive disorder (OCD) after 12 weeks evidence-based treatment.Post hoc analyses were conducted using data from a multisite, randomized, controlled trial comparing the effects exposure ritual prevention (EX/RP), clomipramine (CMI), their combination (EX/RP+CMI), or pill placebo (PBO) 122 OCD (DSM-III-R DSM-IV criteria). Response was defined as decrease symptoms; minimal symptoms treatment. Different definitions...
Objective-To examine the effects of patient adherence on outcome from exposure and response prevention (EX/RP) therapy in adults with obsessive-compulsive disorder (OCD).Method-Thirty OCD were randomized to EX/RP (n=15) or augmented by motivational interviewing strategies (n=15).Both treatments included three introductory sessions 15 sessions.Because there no significant group differences outcome, groups combined outcome.Independent evaluators assessed severity using Yale-Brown Obsessive...
Article AbstractBackground: Obsessive-compulsive disorder (OCD) is defined both by intrusive, unwanted thoughts, images, or impulses and repetitive behavioral mental acts that are often performed to try alleviate anxiety. The ultimate goal of treatment for OCD reduce the symptoms as well help patients achieve "wellness." Currently, however, there no widely accepted, empirically supported criteria determining wellness in OCD.Method: Building on previous research, current study examined...
Abstract Cortico‐striato‐thalamo‐cortical (CSTC) loops project from the cortex to striatum, then striatum thalamus via globus pallidus, and finally back again. These have been implicated in Obsessive‐Compulsive Disorder (OCD) with particular focus on limbic CSTC loop, which encompasses orbitofrontal anterior cingulate cortices, as well ventral striatum. Resting state functional‐connectivity MRI (rs‐fcMRI) studies, examine temporal correlations neural activity across brain regions at rest,...
Abstract Individuals with anorexia nervosa (AN) are often characterized as possessing excessive self-control and unusual in their ability to reduce or avoid the consumption of palatable foods. This behavior promotes potentially life-threatening weight loss suggests disturbances reward processing. We studied whether individuals AN showed evidence increased by examining tendency delay receipt a monetary, non-food related, reward. Underweight ( n = 36) healthy controls (HC, 28) completed...
ABSTRACT Objective Anorexia nervosa (AN) is a severe illness with high rates of relapse. Exposure and Response Prevention for AN (AN‐EXRP) new approach that specifically addresses maladaptive eating behavior by targeting eating‐related fear anxiety. The aim this study was to evaluate AN‐EXRP as an adjunctive strategy improve during weight restoration, at pivotal moment when treatment goals shift toward relapse prevention. Method A randomized controlled trial conducted compare comparison...