A5003121665- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Electroconvulsive Therapy Studies
- Photoreceptor and optogenetics research
- Transcranial Magnetic Stimulation Studies
- Treatment of Major Depression
- Neurological disorders and treatments
- Neuroscience and Neural Engineering
- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Neurotransmitter Receptor Influence on Behavior
- Circadian rhythm and melatonin
- Autism Spectrum Disorder Research
- Neuroendocrine regulation and behavior
- Ion channel regulation and function
- Stress Responses and Cortisol
- Neuropeptides and Animal Physiology
- Free Will and Agency
- Obsessive-Compulsive Spectrum Disorders
- Deception detection and forensic psychology
- Congenital heart defects research
- Genetics and Neurodevelopmental Disorders
- Genomic variations and chromosomal abnormalities
University of Connecticut
2022-2025
UConn Health
2022
MIND Research Institute
2015-2021
Cornell University
2015-2021
Weill Cornell Medicine
2017-2021
Columbia University
2008-2017
New York Psychoanalytic Society and Institute
2008-2012
New York State Psychiatric Institute
2008-2012
Columbia University Irving Medical Center
2009
Although cortico-striato-thalamo-cortical (CSTC) circuit dysregulation is correlated with obsessive compulsive disorder (OCD), causation cannot be tested in humans. We used optogenetics mice to simulate CSTC hyperactivation observed OCD patients. Whereas acute orbitofrontal cortex (OFC)-ventromedial striatum (VMS) stimulation did not produce repetitive behaviors, repeated over multiple days generated a progressive increase grooming, mouse behavior related OCD. Increased grooming persisted...
Despite the increasing use of optogenetics in vivo, effects direct light exposure to brain tissue are understudied. Of particular concern is potential for heat induced by prolonged optical stimulation. We demonstrate that high-intensity light, delivered through an fiber, capable elevating firing rate locally, even absence opsin expression. Predicting severity and spatial extent any temperature increase during optogenetic stimulation therefore considerable importance. Here, we describe a...
Cross-frequency coupling supports the organization of brain rhythms and is present during a range cognitive functions. However, little known about whether how long-range cross-frequency across distant regions subserves working memory. Here we report that theta-slow gamma between hippocampus medial prefrontal cortex (mPFC) augmented in genetic mouse model dysfunction. This increased observed specifically when mice successfully perform spatial memory task. In wild-type mice, increasing task...
The study of the neural circuitry underlying complex mammalian decision-making, particularly cognitive flexibility, is critical for understanding psychiatric disorders. To test as well potentially other decision-making paradigms involving multimodal sensory perception, we developed FlexRig, an open-source, modular behavioral platform use in head-fixed mice. FlexRig enables administration tasks relying upon olfactory, somatosensory, and/or auditory cues and employing left right licking a...
ABSTRACT In autism spectrum disorder (ASD), a neurodevelopmental with social-cognitive deficits, macrocephaly occurs in 20% of patients severe symptoms. However, the role ASD pathogenesis remains unclear. Here, we address mechanistic link between and by investigating novel ASD-associated gain-of-function A1877T mutation ASPM ( abnormal spindle-like microcephaly-associated ). is key regulator cortical size cell proliferation expressed both excitatory inhibitory neuronal progenitors but not...
Abstract Self-ordered spatial working memory measures provide important information regarding underlying cognitive strategies, such as stereotypy. This strategy is based on repetitive sequential selection of a pattern once correct sequence has been identified. We previously reported that electroconvulsive shock (ECS) but not magnetic seizure therapy (MST) impaired performance task in preclinical model. Here we tested the hypothesis ECS disrupted stereotyped patterns stimuli. In...
Magnetic seizure therapy (MST) is under development as a means of reducing the side effects electroconvulsive (ECT) through enhanced control over patterns induction and spread. We previously reported that chronic treatment with MST resulted in less impairment cognitive function than shock (ECS) non-human primate model convulsive therapy. Here we present quantitative analyses ictal expression post-ictal suppression following ECS, MST, anesthesia-alone sham same to test whether differential...
Magnetic seizure therapy (MST) is under development as a means of improving cognitive outcomes with convulsive through achieving better control over therapeutic induction than possible conventional electroconvulsive therapy. In this investigation, we present the first neurophysiological characterization high-dose MST (HD-MST, 6x threshold) to see if higher dose that often used in human trials retains differential expression relative shock (ECS) and explore relationship between outcomes. To...
Abstract The amygdala and prelimbic cortex (PL) communicate during fear discrimination retrieval, but how they coordinate to discriminate a non-threatening stimulus is unknown. Here, we show that somatostatin interneurons (SOM) in the basolateral (BLA) become active specifically learned cues, when block sensory-evoked phase resetting of theta-oscillations. Further, SOM activation PL-dependent, promotes non-threat. Thus, engages PL-dependent coordination BLA responses stimuli.
Summary Cognitive flexibility, the ability to alter one’s strategy according changing stimulus-response-reward relationships, is critical for acquiring and updating learned behavior. Attentional set-shifting, a test of cognitive depends on activity prefrontal cortex (PFC). It remains unclear, however, what specific role PFC neurons play how they interact support set-shifting. One widely held view that biases sensorimotor responses by mediating attention. Using optogenetics 2-photon calcium...
Cognitive flexibility, the ability to alter one’s strategy in light of changing stimulus-response-reward relationships, is critical for acquiring and updating learned behavior by trial error. Successful performance attentional set-shifting, a test cognitive has been shown critically involve prefrontal cortex (PFC). It unclear, however, whether PFC neurons support set-shifting guiding action selection or monitoring feedback from completed actions. Using optogenetics 2-photon calcium imaging,...