A5102866945- Nitric Oxide and Endothelin Effects
- Estrogen and related hormone effects
- Menopause: Health Impacts and Treatments
- Redox biology and oxidative stress
- Coronary Interventions and Diagnostics
- Pulmonary Hypertension Research and Treatments
- Hormonal Regulation and Hypertension
- Cardiovascular Function and Risk Factors
- S100 Proteins and Annexins
- Hormonal and reproductive studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Nanoparticles: synthesis and applications
- Cardiac Valve Diseases and Treatments
- Neuroscience of respiration and sleep
- Hydrogen's biological and therapeutic effects
- Cardiac Structural Anomalies and Repair
- Genetics and Neurodevelopmental Disorders
- Cardiovascular Effects of Exercise
- Aortic aneurysm repair treatments
- Cardiac Ischemia and Reperfusion
- Flavonoids in Medical Research
- Eicosanoids and Hypertension Pharmacology
- Extracellular vesicles in disease
- Neuropeptides and Animal Physiology
- Adenosine and Purinergic Signaling
University of Hong Kong
2023
Hong Kong Polytechnic University
2020-2023
Chinese University of Hong Kong
2003-2018
Chinese University of Hong Kong, Shenzhen
2018
Hong Kong Baptist University
2017
Georgetown University
2007-2009
Georgetown University Medical Center
2007-2009
George Washington University
2007
Washington University Medical Center
2007
Uniformed Services University of the Health Sciences
2007
Reactive oxygen species serve as second messengers for signal transduction; however, molecular targets of oxidant signaling have not been defined. Here, we show that ligand-receptor-mediated promotes reactive species-dependent protein carbonylation. Treatment pulmonary artery smooth muscle cells with endothelin-1 increased carbonyls. Carbonylation the majority proteins occurred transiently, suggesting there is also a mechanism decarbonylation induced by endothelin-1. Decarbonylation was...
Significance Endothelial dysfunction plays a crucial role in the development of diabetic vasculopathy, but mechanisms are not fully understood. In this study, we have revealed previously undefined importance serum exosomes regulating endothelial function and vascular homeostasis diabetes. Through comparative proteomics analysis, arginase1 was found enriched can be transferred to cells inhibit NO production, thus impairing function. This is cell-to-cell communication mechanism first...
Angiotensin-converting enzyme 2 (ACE2)-angiotensin (1-7) [Ang (1-7)]-Mas constitutes the vasoprotective axis and is demonstrated to antagonize vascular pathophysiological effects of classical renin-angiotensin system. We sought study hypothesis that upregulation ACE2-Ang signaling protects endothelial function through reducing oxidative stress would result in beneficial outcome diabetes.Ex vivo treatment with Ang enhanced endothelium-dependent relaxation (EDR) renal arteries from diabetic...
Abstract Stent implantation into an infarct‐related artery during acute myocardial infarction is generally contraindicated because of the risk stent thrombosis. We report on 3 patients who had successful stenting for occlusive dissection that developed direct infarct coronary angioplasty and was refractory to conventional prolonged balloon dilatation, with good long‐term clinical angiographic results. The prerequisites success include proper premedication, presence only a minimal amount...
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We describe our experience with the ChoiCE PT (Boston Scientific Corporation, MN) guidewire, which resulted in perforation of distal coronary artery two instances. This newly introduced guidewire differs from earlier guidewires its ability to cross lesions tortuous arteries. However, when it buckles deep artery, can easily result. While is a useful addition armamentarium interventional procedures, should be treated care. Cathet. Cardiovasc. Diagn. 44:93–96, 1998. © 1998 Wiley-Liss, Inc.
17β-Estradiol and progesterone were found to relax various vascular beds through multiple mechanisms. However, the exact ionic mechanisms underlying acute relaxant responses both hormones are incompletely understood. This study was aimed examine possible role of K+ channel activation in relaxation induced by isolated rat mesenteric artery rings. Isometric tension each ring measured with Grass force displacement transducers. In endothelium–denuded rings preconstricted...
Background and Objectives. Oxidative stress can initiate endothelial dysfunction atherosclerosis. This study evaluated whether tetramethylpyrazine (TMP), the predominant active ingredient in Rhizoma Ligustici Wallichii (chuanxiong), prevents a rat model of oxidative stress. Methods. Isolated aortic rings were pretreated with various drugs before induction by hydrogen peroxide (H2O2). Changes isometric tension then measured acetylcholine- (ACh-) relaxed rings. Endothelial nitric oxide...
Background and Purpose Raloxifene can induce both endothelium‐dependent ‐independent relaxation in different arteries. However, the underlying mechanisms by which raloxifene triggers endothelium‐independent are still incompletely understood. The purpose of present study was to examine roles NOSs Ca 2+ channels relaxant response rat isolated, endothelium‐denuded aorta. Experimental Approach Changes isometric tension, cGMP, nitrite, inducible NOS protein expression distribution aortic rings...
Pinacidil relaxes blood vessels through opening the K ATP channels with a resultant membrane hyperpolarization and inhibition of Ca 2+ influx. The aim this study was to examine mechanisms thereby pinacidil induces + channel‐independent relaxation in isolated endothelium‐denuded rat mesenteric artery. Pinacidil‐induced inhibited by glibenclamide (1–10 μ M ) phenylephrine‐preconstricted rings, but unaffected after VGCCs. remained unchanged treatment cyclopiazonic acid (10 ), thapsigargin (1...
Background Pin2/TRF1-interacting protein, PinX1, was previously identified as a tumor suppressor. Here, we discovered novel transcript variant of mPinX1 (mouse PinX1), mPinX1t PinX1t), in embryonic stem cells (ESCs). The aims this investigation were (1) to detect the presence and ESCs their differentiation derivatives; (2) investigate role on regulating characteristics undifferentiated cardiac ESCs; (3) elucidate molecular mechanisms how regulate ESCs. Methods Results By 5' rapid...
Adaptive thermogenesis is a vital physiological process for small endotherms. Female animals usually are more sensitive to cold temperature due anatomical differences. Whether there sex difference at molecular level unclear. Stress granules (SGs) dynamic organelles in which untranslated mRNAs reside during cellular stress. We hypothesize that the prompt response of SGs stress can reveal between sexes. By analyzing content brown adipose tissue (BAT) early phase both sexes, we found diverse...