A5091252785- Porphyrin and Phthalocyanine Chemistry
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Luminescence and Fluorescent Materials
- Metal-Catalyzed Oxygenation Mechanisms
- Magnetism in coordination complexes
- Crystallography and molecular interactions
- Photosynthetic Processes and Mechanisms
- Photochromic and Fluorescence Chemistry
- Advanced biosensing and bioanalysis techniques
- Molecular Sensors and Ion Detection
- Photochemistry and Electron Transfer Studies
- Click Chemistry and Applications
- Supramolecular Chemistry and Complexes
- Organometallic Complex Synthesis and Catalysis
- Surface Chemistry and Catalysis
- Oxidative Organic Chemistry Reactions
- Ferrocene Chemistry and Applications
- Metal complexes synthesis and properties
- Chemical Synthesis and Reactions
- Porphyrin Metabolism and Disorders
- Research on Leishmaniasis Studies
- Cancer Research and Treatments
Chinese University of Hong Kong
2016-2025
Robert Bosch (Germany)
2024
Shatin Hospital
2016-2021
Osaka University
2010-2012
Novel (United States)
2010
Shandong University
2002-2009
Humboldt-Universität zu Berlin
2007
Hong Kong Baptist University
2007
Tohoku University
2004-2006
Liaocheng University
2004
Phthalocyanines and porphyrins are versatile functional pigments with a wide range of applications. These macrocyclic compounds contain four isoindole or pyrrole nitrogen atoms, which can complex metal ions. Large rare earth ions bring together these tetrapyrrole derivatives to form sandwich-type double- triple-decker complexes. Depending on the centers nature ligands, exhibit tunable spectroscopic, electronic, redox properties, different extents intramolecular pi-pi interactions. Some...
An advanced photodynamic molecular beacon (PMB) was designed and synthesized, in which a distyryl boron dipyrromethene (DSBDP)-based photosensitizer Black Hole Quencher 3 moiety were connected via two peptide segments containing the sequences PLGVR GFLG, respectively, of cyclic peptide. These short are well-known substrates matrix metalloproteinase-2 (MMP-2) cathepsin B, both overexpressed wide range cancer cells either extracellularly (for MMP-2) or intracellularly B). Owing to efficient...
The effect of substituents on the electrochemistry metal-free phthalocyanines was examined for 17 phthalocyanine compounds. This work also provides new information about electron-donating or -withdrawing nature various substituents, namely, alkoxy, alkylthio, alkyl, alkynyl, phenyloxy, and phenylthio groups attached to system, from viewpoint electrochemistry. Most effects peripheral nonperipheral substitution changes in ring (pi-conjugated system) size can be reasonably explained by...
Two novel subphthalocyanines substituted axially with a BODIPY or distyryl moiety have been synthesized. Both systems exhibit highly efficient photoinduced energy transfer process, either from the excited to subphthalocyanine core (for former) unit latter).
A novel bis(ferrocenyl chalcone) silicon(IV) phthalocyanine has been prepared in which the disulfide linker can be cleaved by dithiothreitol. The separation of ferrocenyl quencher and core greatly enhances fluorescence emission, singlet oxygen production vitro photocytotoxicity.
An unsymmetrical bisferrocenyl silicon(IV) phthalocyanine has been prepared in which the disulfide and hydrazone linkers can be cleaved by dithiothreitol acid, respectively. The separation of ferrocenyl quenchers core greatly enhances fluorescence emission, singlet oxygen production, intracellular intensity, vitro photocytotoxicity. results have compared with those for two symmetrical analogues contain either or linker therefore only activated one these stimuli. For dual activatable agent,...
A facile approach to assemble catalase-like photosensitizing nanozymes with a self-oxygen-supplying ability was developed. The process involved Fe3+ -driven self-assembly of fluorenylmethyloxycarbonyl (Fmoc)-protected amino acids. By adding zinc(II) phthalocyanine-based photosensitizer (ZnPc) and the hypoxia-inducible factor 1 (HIF-1) inhibitor acriflavine (ACF) during -promoted Fmoc-protected cysteine (Fmoc-Cys), nanovesicles Fmoc-Cys/Fe@Pc Fmoc-Cys/Fe@Pc/ACF were prepared, which could be...
Abstract A novel coumarin–rhodamine conjugate was prepared, and its metal binding properties were studied by UV/Vis fluorescence spectroscopy. The serves as a ratiometric highly selective fluorescent sensor for Hg 2+ ions. Its metal‐responsive spectral utilized to construct molecular keypad lock with four inputs dual outputs. complexity of this logic network can greatly enhance the security level device.
Abstract Polymeric metal phthalocyanines have great potential as electrocatalysts, yet their incorporation on a current collector without losing the activity of centers remains challenge. Herein, new strategy for preparing series polymeric cobalt containing S linkers ( p CoPc‐1) or SO 2 CoPc‐2) and tunable electrochemical properties are reported. The CoPcs coated various substrates show favorable electrocatalytic activities toward oxygen hydrogen evolution reactions (OER HER). Particularly,...
Delivery of functional proteins into the intracellular space has been a challenging task that could lead to myriad therapeutic applications. We report herein novel bioconjugation strategy for enzyme modification and selective delivery cancer cells lock-and-key-type activation photosensitizers. Using bifunctional linker containing bis(bromomethyl)phenyl group an o-phthalaldehyde moiety, it induce cyclization peptide sequence Ac-NH-CRGDfC-CONH2 through site-specific dibenzylation with two...
Manipulation of cell–cell interactions via cell surface modification is crucial in tissue engineering and cell-based therapy. To be able to monitor intercellular interactions, it can also provide useful information for understanding how the cells interact communicate. We report herein a facile bioorthogonal strategy promote interactions. It involves use maleimide-appended tetrazine-caged boron dipyrromethene (BODIPY)-based fluorescent probe maleimide-substituted bicyclo[6.1.0]non-4-yne (BCN)...
The infiltration and cytotoxicity of chimeric antigen receptor (CAR)-T cells are crucial for effective elimination solid tumors. While metallo-immunotherapy is a promising strategy that can activate the antitumor immunity, its role in promoting CAR-T cell therapy remains elusive. first single-element nanomaterial based on chromium nanoparticles (Cr NPs) cancer photo-metallo-immunotherapy has been reported previously. Herein, an extended study using biodegradable polydopamine as versatile...
A series of 7 cerium double-decker complexes with various tetrapyrrole ligands including porphyrinates, phthalocyaninates, and 2,3-naphthalocyaninates have been prepared by previously described methodologies characterized elemental analysis a range spectroscopic methods. The molecular structures two heteroleptic [(na)phthalocyaninato](porphyrinato) also determined X-ray diffraction which exhibit slightly distorted square antiprismatic geometry domed ligands. Having very different electronic...
A series of phthalocyanines containing four dendritic substituents with terminal ester or carboxylate functionalities have been synthesized. These compounds having bulky are essentially nonaggregated in organic solvents (for the series) water [G1] and [G2] as demonstrated by absorption fluorescence spectroscopy. Photoinduced electron transfer these has investigated a quenching method using neutral, anionic, cationic quenchers. The rates depend largely on size dendrons. For (TMePyP)4+...
A novel series of silicon(IV) phthalocyanines substituted axially with one or two 1,3-bis(dimethylamino)-2-propoxy group(s) have been prepared by ligand substitution and alkoxy exchange reactions. Two dicationic tetracationic also methylation these compounds. The nonionic are essentially nonaggregated in common organic solvents show a weak fluorescence emission, while the methylated derivatives nonaggregated, even aqueous media, exhibit strong emission. These new phthalocyanines, particular...
A series of silicon(IV) phthalocyanines substituted axially with different polyamine moieties have been prepared. Their fluorescence quantum yields (Φ(F) = 0.03-0.08) in N,N-dimethylformamide are low because reductive quenching by the amino moieties. The values significantly increased aqueous media 0.12-0.21) as a result protonation substituents. All compounds highly photocytotoxic against human colon adenocarcinoma HT29 cells and Chinese hamster ovary IC(50) 1.1 nM. Flow cytometric studies...
A novel tetraamino silicon(IV) phthalocyanine has been prepared, of which the fluorescence emission and reactive oxygen species generation efficiency are greatly enhanced at lower pH in range ca. 5–7, making it a promising pH-controlled tumour-selective probe photosensitiser for photodynamic therapy.
A novel zinc(II) phthalocyanine substituted with an oxaliplatin derivative via a triethylene glycol linker has been synthesized. The two components work in cooperative manner the antitumor action. conjugate shows cytotoxic effect dark due to cytostatic moiety and enhanced cytotoxicity upon illumination photosensitizing unit against HT29 human colon adenocarcinoma cells. IC(50) value of is as low 0.11 μM, which 5-fold lower than that reference compound without platinum complex. high...
A series of unsymmetrical distyryl BODIPYs have been prepared which function as highly potent photosensitisers with in vitro IC(50) values low 15 nM. Their cellular uptake, subcellular localisation and photocytotoxicity depend greatly on the styryl substituents.