A5100405244- Luminescence and Fluorescent Materials
- Nanoplatforms for cancer theranostics
- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- Supramolecular Self-Assembly in Materials
- Photodynamic Therapy Research Studies
- Advanced Nanomaterials in Catalysis
- Analytical Chemistry and Sensors
- Nanocluster Synthesis and Applications
- Porphyrin and Phthalocyanine Chemistry
- Carbon and Quantum Dots Applications
- Nanoparticle-Based Drug Delivery
- Polydiacetylene-based materials and applications
- Cancer, Hypoxia, and Metabolism
- Advanced Photocatalysis Techniques
- Dendrimers and Hyperbranched Polymers
- Cancer Research and Treatments
- Catalytic Cross-Coupling Reactions
- Click Chemistry and Applications
- Microwave-Assisted Synthesis and Applications
- Nematode management and characterization studies
- Plant Pathogens and Fungal Diseases
- Mass Spectrometry Techniques and Applications
- Gas Sensing Nanomaterials and Sensors
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
Qingdao University
2024-2025
Affiliated Hospital of Qingdao University
2025
Nanyang Technological University
2016-2024
Jiangsu Normal University
2024
Henan Polytechnic University
2022-2024
City University of Hong Kong
2019-2023
City University of Hong Kong, Shenzhen Research Institute
2020
Chinese Academy of Sciences
2014-2019
University of Chinese Academy of Sciences
2016-2019
Changchun Institute of Applied Chemistry
2014-2019
Supramolecular photosensitizer nanodrugs that combine the flexibility of supramolecular self-assembly and advantage spatiotemporal, controlled drug delivery are promising for dedicated, precise, noninvasive tumor therapy. However, integrating robust blood circulation targeted burst release in a single nanodrug platform can simultaneously improve therapeutic performance reduce side effects is challenging. Herein, we demonstrate multicomponent coordination strategy versatile potent development...
Tumor-responsive nanocarriers are highly valuable and demanded for smart drug delivery particularly in the field of photodynamic therapy (PDT), where a quick release photosensitizers tumors is preferred. Herein, it demonstrated that protein-based nanospheres, prepared by electrostatic assembly proteins polypeptides with intermolecular disulfide cross-linking surface polyethylene glycol coupling, can be used as versatile tumor-responsive vehicles effective PDT. These nanospheres capable...
A facile approach to assemble catalase-like photosensitizing nanozymes with a self-oxygen-supplying ability was developed. The process involved Fe3+ -driven self-assembly of fluorenylmethyloxycarbonyl (Fmoc)-protected amino acids. By adding zinc(II) phthalocyanine-based photosensitizer (ZnPc) and the hypoxia-inducible factor 1 (HIF-1) inhibitor acriflavine (ACF) during -promoted Fmoc-protected cysteine (Fmoc-Cys), nanovesicles Fmoc-Cys/Fe@Pc Fmoc-Cys/Fe@Pc/ACF were prepared, which could be...
Supramolecular near-infrared (NIR) nanomaterials show great application prospects in cancer photothermal immunotherapy. However, the direct self-assembly of absorbed biological transparent window and control over their absorption properties through aggregation behavior remains a grand challenge. Here, superlarge redshift (ranging from 105 nm to 150 nm) mono-α-substituted carboxy zinc phthalocyanine (αZnPc) kinetic assembly methodologies is demonstrated, resulting fabrication nanoagents...
Superquenching of aggregation-induced emission (AIE) has been utilized in biosensing for the first time. A positively charged tetraphenylethene derivative (compound 1) showed no an aqueous buffer solution. single-stranded DNA (a polyanion) induced aggregation compound 1, and strong 1 aggregate was observed. When labeled with a quencher molecule, efficiently quenched. On basis this observation, new, simple, sensitive selective methyltransferase (MTase) assay developed. quencher-labeled...
Interference with glycolysis metabolism not only promotes the efficient sensitization of cuproptosis, but also amplifies cytotoxic T cell functions and proliferations, thus contributing to relieve immunosuppressive tumor microenvironment. However, synergistic mechanism design multicomponent nanoformulations involving these three pathways have yet been explored. a copper-coordinated nanoassembly (designated as Cu-GM) is reported here that integrates lactate dehydrogenase inhibitor,...
Two zinc(II) phthalocyanines (ZnPcs) substituted with a short peptide (Gly-Gly-Lys) either carboxyl or carbamoyl group at the C-terminus and an appended biotin moiety were prepared characterized. They could self-assemble into spherical nanoparticles, namely ZnPc-GGK(B)-COOH NP ZnPc-GGK(B)-CONH2 NP, through noncovalent interactions, which encapsulated hydrophobic ZnPc units in core exposed moieties on surface. The zeta potential of water was found to be -28 mV, whereas that opposite sign (+15...
Tunable aggregation-induced emission of tetraphenylethylene is well realized via short peptide-directed self-assembly associated with synergy noncovalent intermolecular interactions, including electrostatic, hydrophobic, and π–π interactions. Cationic diphenylalanine can enhance the fluorescence signal (TPE) nanoparticles, while 9-fluorenylmethoxycarbonyl-l-Lysine weaken TPE nanoparticles. As a service to our authors readers, this journal provides supporting information supplied by authors....
A series of 2-alkenyl- and 2,6-dialkenylboron dipyrromethene (BODIPY) derivatives were synthesized through Pd(II)-catalyzed regioselective stereoselective oxidative C–H olefination in one step. The 2-alkenyl BODIPY derivative further reacted with various amines regioselectively at the 5-position direct nucleophilic substitution. photophysical properties 2,6-dialkenyl-substituted BODIPYs investigated, which showed great potential fluorescent bioimaging.
A novel choline detection strategy is developed based on in situ polymerization of aniline the surface upconverting nanoparticles (UCNPs). In acidic buffer solution, was protonated and attached to negatively charged UCNPs via electrostatic interactions. The initiated with addition a catalyst (HRP) an oxidization agent (H2O2). upconversion luminescence efficiently quenched by polyaniline (PANI), quenching efficiency could reach 97.5%, which higher than most reported organic quenchers for...
Abstract A facile approach to assemble catalase‐like photosensitizing nanozymes with a self‐oxygen‐supplying ability was developed. The process involved Fe 3+ ‐driven self‐assembly of fluorenylmethyloxycarbonyl (Fmoc)‐protected amino acids. By adding zinc(II) phthalocyanine‐based photosensitizer (ZnPc) and the hypoxia‐inducible factor 1 (HIF‐1) inhibitor acriflavine (ACF) during ‐promoted Fmoc‐protected cysteine (Fmoc‐Cys), nanovesicles Fmoc‐Cys/Fe@Pc Fmoc‐Cys/Fe@Pc/ACF were prepared, which...
Autophagy, a conserved cellular recycling process, plays crucial role in maintaining homeostasis under stress conditions. It also regulates the development and virulence of numerous filamentous fungi. In this study, we investigated specific function ATG8, reliable autophagic marker, opportunistic pathogen
Protein-based nanospheres, fabricated by protein and polypeptide co-assembly, are developed as versatile drug delivery vehicles for photosensitizers. On page 5936, X. Yan co-workers describe how the responsiveness of nanospheres to changes in pH/redox/enzyme stimuli leads efficient multi-triggered tumor-responsive photodynamic tumor ablation.
The ability of chemists to master catalysis and small molecule activation can be largely attributed the rational design a wide range tunable ligand frameworks. Striking results in this area have been achieved using N-heterocyclic carbenes (NHCs) due their steric electronic properties. Among these systems, NHCs with inorganic backbones demonstrated significant potential areas distinctive properties compared organic counterparts. Within group, phosphazane hybrid (PHNHCs) species proposed as...
Xuehai Yan and co-workers describe a method to tune the aggregation-induced emission of tetraphenylethylene (TPE) via short peptide-directed self-assembly based on synergy noncovalent intermolecular interactions in article 1600183. Cationic diphenylalanine can make TPE nanoparticle brighter, while 9-fluorenylmethoxycarbonyl-l-Lysine it darker.