A5089474387- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Chromatin Remodeling and Cancer
- Mechanisms of cancer metastasis
- Circular RNAs in diseases
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Immune cells in cancer
- Metastasis and carcinoma case studies
- CAR-T cell therapy research
- Cancer Mechanisms and Therapy
- Gut microbiota and health
- Immunotherapy and Immune Responses
- Natural product bioactivities and synthesis
- RNA Research and Splicing
- Cancer Cells and Metastasis
- T-cell and B-cell Immunology
- Cancer, Lipids, and Metabolism
- Traditional Chinese Medicine Analysis
- Cancer, Hypoxia, and Metabolism
- Genomics, phytochemicals, and oxidative stress
First Affiliated Hospital of Sichuan Medical University
2019-2025
Southwest Medical University
2016-2025
Shanghai Cell Therapy Research Institute
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2024
Agriculture and Agri-Food Canada
2024
Guelph Research and Development Centre
2024
Zhongnan Hospital of Wuhan University
2024
Wuhan University
2024
Sichuan Academy of Traditional Chinese Medicine
2024
Hebei Medical University
2024
Gene expression can be posttranscriptionally regulated by a complex network of proteins. N1-methyladenosine (m1A) is newly validated RNA modification. However, little known about both its influence and biogenesis in tumor development. This study analyzed TCGA data patients with five kinds gastrointestinal (GI) cancers. Using from cBioPortal, molecular features the nine m1A-related enzymes GI cancers were investigated. variety bioinformatics approach, impact m1A regulators on downstream...
Abstract Chromatin remodeling has emerged as a hallmark of gastric cancer, but the regulation chromatin regulators other than genetic change is unknown. Helicobacter pylori causes epigenetic dysregulation to promote carcinogenesis, roles and functions microRNAs (miRNA) in this multistage cascade are not fully explored. In study, miRNA expression preneoplastic neoplastic lesions murine stomachs induced by H. N-methyl-N-nitrosourea (MNU) was profiled array. miR-490-3p exhibited progressive...
Shikonin (SKN), a naphthoquinone compound, is isolated from Chinese herbal medicine Lithospermum root and has been studied as an anticancer drug candidate in human tumor models. This study designed to investigate whether SKN can sensitize the therapeutic effect of paclitaxel (PTX) drug-resistant ovarian carcinoma cells.Human A2780 cell along with paired PTX-resistant A2780/PTX cells were used. The effects SKN, PTX or their combination on viability conducted using Sulforhodamine B assay....
The introduction of targeted therapy is the biggest success in treatment cancer past few decades. However, heterogeneous characterized by diverse molecular alterations as well multiple clinical profiles. Specific genetic mutations targets may increase drug sensitivity, or more frequently result therapeutic resistance. In three years, several novel therapies have been approved for treatment, including drugs with new (i.e., anti-PD1/PDL1 and CDK4/6 inhibitors), mutation targeting EGFR T790M...
The highly intra-tumoral heterogeneity and complex cell origination of prostate cancer greatly limits the utility traditional bulk RNA sequencing in finding better biomarker for disease diagnosis stratification. Tissue specimens based single-cell holds great promise identification novel biomarkers. However, this technique has yet been used study heterogeneity.
Rationale: Methylation at the N6 position of adenosine (m6A) is most prevalent RNA modification within protein-coding mRNAs in mammals, and it a reversible with various important biological functions. The formation function m6A are regulated by methyltransferases (writers), demethylases (erasers), special binding proteins (readers) as key factors. However, underlying mechanisms gastrointestinal (GI) cancer remain unclear. Here, we performed comprehensive molecular profiling nine known...
<italic>Rhodiola crenulata</italic>extract alleviates DSS-induced colitis in mice through anti-inflammation, mediating gut barrier integrity and reshaping the microbiome.
Background: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in world. The efficacy immunotherapy usually depends on interaction immunomodulation tumor microenvironment (TME). This study aimed to explore potential stromal-immune score-based prognostic genes related HCC through bioinformatics analysis. Methods: ESTIMATE algorithm was applied calculate immune/stromal/Estimate scores and purity using Cancer Genome Atlas (TCGA) transcriptome data. Functional enrichment...
Objectives Several reports suggesting that the intestinal microbiome plays a key role in development of inflammatory bowel disease (IBD) or colorectal cancer (CRC), but changes bacteria healthy people, patients with IBD and CRC are not fully explained. The study aimed to investigate subjects, IBD, CRC. Materials We collected data from European Nucleotide Archive on people accession number PRJEB6070, PRJEB7774, PRJEB27928, PRJEB12449, PRJEB10878, patient Integrated Human Microbiome Project...
Abstract As immune checkpoint inhibitors (ICIs) continue to advance, more evidence has emerged that anti-PD-1/PD-L1 immunotherapy is an effective treatment against cancers. Known as the programmed death ligand-1 (PD-L1), this co-inhibitory ligand contributes T cell exhaustion by interacting with death-1 (PD-1) receptor. However, cancer-intrinsic signaling pathways of PD-L1 molecule are not well elucidated. Therefore, present study aimed evaluate regulatory network and lay basis successful...