A5075960242- Higher Education and Teaching Methods
- Cancer-related molecular mechanisms research
- Education and Work Dynamics
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Natural product bioactivities and synthesis
- Fungal Biology and Applications
- Innovative Educational Techniques
- Radioactive element chemistry and processing
- Extracellular vesicles in disease
- Pharmacogenetics and Drug Metabolism
- Educational Technology and Assessment
- Angiogenesis and VEGF in Cancer
- China's Ethnic Minorities and Relations
- 14-3-3 protein interactions
- Berberine and alkaloids research
- Advanced ceramic materials synthesis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer Immunotherapy and Biomarkers
- Drug Transport and Resistance Mechanisms
- Educational Reforms and Innovations
- Cancer Genomics and Diagnostics
- Microbial Metabolism and Applications
- Medicinal Plant Pharmacodynamics Research
- Chinese history and philosophy
First People's Hospital of Jingzhou
2025
Guangxi Academy of Agricultural Science
2025
Dalian Medical University
2007-2025
First Affiliated Hospital of Dalian Medical University
2025
Dali University
2025
Affiliated Hospital of Southwest Medical University
2024
East China University of Technology
2022-2024
Yangtze University
2013-2024
Shaoxing University
2024
Sun Yat-sen University
2002-2024
Abstract The gut microbiota is important in the pathogenesis of energy-metabolism related diseases. We focused on interaction between intestinal bacteria and orally administered chemical drugs. Oral administration berberine (BBR) effectively treats patients with metabolic disorders. However, because BBR exhibits poor solubility, its absorption mechanism remains unknown. Here, we show that converts into absorbable form dihydroberberine (dhBBR), which has an rate 5-fold animals. reduction to...
Growing evidences indicate that circular RNAs (circRNAs) play an important role in the regulation of biological behavior tumor. We aim to explore circRNA glioma and elucidate how acts.Real-time PCR was used examine expression circPTN tissues normal brain (NBT). Assays dual- luciferase reporter system, biotin label RNA pull-down FISH were determine could sponge miR-145-5p miR-330-5p. Tumor sphere formation assay performed self- renewal stem cell (GSCs). Cell counting Kit-8 (CCK8), EdU flow...
Berberine (BBR) has been confirmed to have multiple bioactivities in clinic, such as cholesterol-lowering, anti-diabetes, cardiovascular protection and anti- inflammation. However, BBR’s plasma level is very low; it cannot explain its pharmacological effects patients. We consider that the vivo distribution of BBR well bioactive metabolites might provide part explanation for this question. In study, liquid chromatography coupled ion trap time-of-flight mass spectrometry (LC/MSn-IT-TOF) with...
Angiogenesis has long been a desired therapeutic approach to improve clinical outcomes of conditions typified by ischemia. Vascular endothelial growth factor (VEGF) demonstrated the ability generate new blood vessels in vivo, but trials using intravenous delivery have not yet produced success. Localized, sustained VEGF proven necessary as implantable, controlled release devices. Ultimately, nanoparticles delivered injection may be designed accumulate target tissues and sustain local...
Berberine (BBR), as a new medicine for hyperlipidemia, can reduce the blood lipids in patients. Mechanistic studies have shown that BBR activates extracellular-signal regulated kinase pathway by stabilizing low-density-lipoprotein receptor mRNA. However, aside from inhibiting intestinal absorption of cholesterol, effects on other metabolic pathways cholesterol not been reported. This study aimed to investigate action excretion high-fat diet-induced hyperlipidemic hamsters. Golden hamsters...
Abstract The prognosis for human glioma, a malignant tumor of the central nervous system, is poor due to its rapid growth, genetic heterogeneity, and inadequate understanding underlying molecular mechanisms. Circular RNAs composed exonic sequences, represent an understudied form noncoding (ncRNAs) that was discovered more than decade ago, function as microRNA sponges. We aimed assess relationship between circ‐U2AF1 (CircRNA ID: hsa_circ_0061868) hsa‐mir‐7‐5p examine their effects on...
Abstract Background Exosomes are membrane-bound extracellular vesicles of 40–150 nm in size, that produced by many cell types, and play an important role the maintenance cellular homeostasis. Exosome secretion allows for selective removal harmful substances from cells. However, it remains unclear whether this process also takes place glioma Methods Herein, tumour-suppressor miR-375 was explored human Immunoblotting qRT-PCR experiments demonstrated a functional link between its target,...
Escherichia coli are part of the normal intestinal microbiome, but some enterohemorrhagic E. (EHEC) and enteropathogenic (EPEC) strains can cause potentially life-threatening gastroenteritis. Virulence factors underlying ability EHEC EPEC to disease include those encoded in locus enterocyte effacement (LEE) pathogenicity island. Here, we demonstrated that EsrL, a small RNA present many strains, promoted pathogenicity, adhesion, biofilm formation EPEC. PhoB, response regulator two-component...
Abstract Background Immune checkpoint inhibitors, which have attracted much attention in recent years, achieved good efficacy, but their use is limited by the high incidence of acquired drug resistance. Therefore, there an urgent need to develop new immunotherapy drugs. Compound taxus chinensis capsule (CTC) oral paclitaxel compound drug, clinical results showed it can change number regulatory T cells and helper cell 17 peripheral blood. Regulating balance between considered be effective...
Vasculogenic mimicry (VM) refers to the process by which highly aggressive tumor cells mimic endothelial form vessel-like structures that aid in supplying enough nutrients rapidly growing tumors. Histone deacetylases (HDACs) regulate expression and activity of numerous molecules involved cancer initiation progression. Notably, HDAC3 is overexpressed majority carcinomas. However, thus far, no data are available support role VM. In this study, we subjected glioma specimens immunohistochemical...
The increasing incidence of hepatocellular carcinoma (HCC) is a major challenge worldwide.In the past few years, an number studies have suggested that circular RNAs (circRNAs) play important role in development human tumors, including HCC, but our understanding their function still limited.In this study, we investigated differences expression circRNA MAN2B2 (circMAN2B2) tissues and paired normal tissues.We found knockdown circMAN2B2 HCC cell lines Hep-G2 Huh-7 significantly inhibited...
Esophageal squamous cell carcinoma (ESCC), a prevalent malignancy within the digestive tract, is associated with significantly high mortality rate. MicroRNAs were already demonstrated to work in wide range of tumors. The objective present research was elucidate involvement miR-103 pathogenesis ESCC and explore its underlying mechanisms action. Real-time quantitative polymerase chain reaction used detect expressions tissues cells. clinical significance these assessed by series statistical...
Objective: The objective of this study is to incorporate narrative medicine (NM) into undergraduate orthodontics educational courses, evaluate its impact on the empathy levels and professional skills students, examine student feedback curriculum. Methods: A cohort 120 fifth-year students enrolled between June 2023 2024 were selected as participants in randomly assigned experimental control groups. Students group received training through traditional teaching methods that combined textbook...
Abstract: Mechanism-based inhibition of cytochrome P450 (CYP) 3A4 is characterized by NADPH-, time-, and concentration-dependent enzyme inactivation, occurring when some drugs are converted CYPs to reactive metabolites. Such CYP3A4 can be due the chemical modification heme, protein, or both as a result covalent binding modified heme protein. The inactivation has important clinical significance it metabolizes approximately 60% therapeutic drugs, its frequently causes unfavorable drug–drug...
Coumarins are plant-derived natural products with a broad range of known pharmacological activities including anticancer effects. However, the molecular mechanisms by which this class promising compounds exerts their effects remain largely unknown. We report here that furanocoumarin named apaensin could effectively induce apoptosis cancer cells through its activation Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAPK). Apoptosis induction in was suppressed chemical...