A5081610363- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- Aluminum Alloys Composites Properties
- Mast cells and histamine
- Cellular and Composite Structures
- Advanced ceramic materials synthesis
- Cholesterol and Lipid Metabolism
- Folate and B Vitamins Research
- Cancer, Stress, Anesthesia, and Immune Response
- Lysosomal Storage Disorders Research
- T-cell and B-cell Immunology
- Neuroscience and Neuropharmacology Research
- Cancer Immunotherapy and Biomarkers
- Systemic Lupus Erythematosus Research
- Cellular transport and secretion
- HIV-related health complications and treatments
- Neurological Disease Mechanisms and Treatments
- Cancer, Hypoxia, and Metabolism
- Gestational Diabetes Research and Management
- Law, Economics, and Judicial Systems
- Genetic Mapping and Diversity in Plants and Animals
- Corruption and Economic Development
- CAR-T cell therapy research
- Brake Systems and Friction Analysis
- Pregnancy and preeclampsia studies
Shandong University
2022-2025
Xi'an University of Architecture and Technology
2025
Institute of Solid State Physics
2002-2024
Chinese Academy of Sciences
2002-2024
Capital Medical University
2024
Beijing Friendship Hospital
2024
Jackson Laboratory
2020-2024
Anhui Jianzhu University
2023-2024
Jackson Laboratories (India)
2024
Wuhan University
2016-2023
A missing link in cholesterol absorption Cholesterol is important for general health, but too much can build up artery walls and cause cardiovascular disease. Low-density lipoprotein (LDL-C) often referred to as “bad cholesterol”; keeping LDL-C within stringent limits recommended reduce the risk of heart attack stroke. Zhang et al. discovered that some individuals have an inherited frameshift mutation LIMA1 gene (also known EPLIN or SREBP3 ). The has not been linked lipid metabolism before,...
Proper intracellular cholesterol trafficking is critical for cellular function. Two lysosome-resident proteins, NPC1 and NPC2, mediate the egress of low-density lipoprotein-derived from lysosomes. However, other proteins involved in this process remain largely unknown. Through amphotericin B-based selection, we isolated two transport-defective cell lines. Subsequent whole-transcriptome-sequencing analysis revealed lines bearing same mutation vacuolar protein sorting 53 (Vps53) gene....
As a city–county consolidation with Chinese characteristics, China's county-to-district (CtD) reform transfers county's autonomy to city, thereby strengthening the administrative, decision-making, fiscal and other powers of prefecture-level municipal government, which effectively enables centralization local governments. Based on this exogenous quasi-natural experiment, we use difference-in-differences (DID) approach empirically examine impact government companies' ESG performance. The...
This study aimed to analyze the correlation of urine protein/creatinine ratio (UPCR) in late pregnancy with outcomes patients preeclampsia (PE) combined hyponatremia. The data 288 PE were collected and compiled for retrospective analysis. divided into two groups: observation group (52 cases, complicated hyponatremia) control (236 not hyponatremia). general conditions, clinical data, adverse maternal infant statistically analyzed both groups. Risk factors using logistic regression, predictive...
SiC nanowires/reduced graphene oxide (SiC NWs /RGO) composites with layered porous structures exhibit good electromagnetic wave absorption (EWA) performance.
Neuronal spike encoding and synaptic transmission in the brain need be precise reliable for well-organized behavior cognition. Little is known about how a unitary synapse reliably transmits presynaptic sequential spikes multiple synapses precisely drive their postsynaptic neurons to encode spikes. To address these questions, we investigated dynamics of glutamatergic as well role driving cortical fast-spiking neurons. Synaptic patterns randomly fluctuate among facilitation, depression...
The increasing incidence of hepatocellular carcinoma (HCC) is a major challenge worldwide.In the past few years, an number studies have suggested that circular RNAs (circRNAs) play important role in development human tumors, including HCC, but our understanding their function still limited.In this study, we investigated differences expression circRNA MAN2B2 (circMAN2B2) tissues and paired normal tissues.We found knockdown circMAN2B2 HCC cell lines Hep-G2 Huh-7 significantly inhibited...
Prior evidence indicates that homocysteine plays a role in the development of metabolic syndrome (MetS). Methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase (MTRR) A66G polymorphisms are common genetic determinants levels. To investigate associations MTHFR MTRR with MetS, 692 Chinese Han subjects MetS 878 controls were recruited. The component traits genotypes determined. A significant association was observed between 677T allele increased risk high fasting blood...
On the basis of nonequilibrium Keldysh Green's function technique, we study current-induced heat generation $Q$ in a quantum dot (QD) taking both bias voltage and rotating magnetic field into consideration. It is found that under conditions small voltage, weak dot-lead coupling strength, low temperature, generated mainly decided by probability each electron to scatter off phonon shows properties. As result this, many interesting phenomena absent macroscopic devices appear. For example, when...
Abstract Cytotoxic T lymphocytes (CTL) are pivotal in combating cancer, yet their efficacy is often hindered by the immunosuppressive tumor microenvironment, resulting CTL exhaustion. This study investigates role of interleukin-3 (IL3) orchestrating antitumor immunity through modulation. We found that intratumoral CTLs exhibited a progressive decline IL3 production, which was correlated with impaired cytotoxic function. Augmenting supplementation, intraperitoneal administration recombinant...
Although both methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase (MTRR) A66G polymorphisms have been associated with type 2 diabetes (T2D), their interactions being overweight/obesity on T2D risk remain unclear. To evaluate the associations of two risk, a case-control study 180 patients 350 healthy controls was conducted in northern China. Additive interaction estimated using relative excess due to (RERI), attributable proportion (AP) synergy index (S). After...
Little is known regarding the interactions of methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase (MTRR) A66G polymorphisms with overweight/obesity on serum lipid profiles. The aim current study was to explore between two four common levels in a Chinese Han population further evaluate whether these exhibit gender-specificity.A total 2239 participants (750 females 1489 males) were enrolled into this study. genotypes MTHFR MTRR determined by TaqMan assay. Overweight...
Objective: A high level of LDL-C (low-density lipoprotein cholesterol) is a major risk factor for cardiovascular disease. The E3 ubiquitin ligase named IDOL (inducible degrader the LDLR [LDL receptor]; also known as MYLIP [myosin regulatory light chain interacting protein]) mediates degradation through ubiquitinating its C-terminal tail. But expression profile differs greatly in livers mice and humans. Whether able to regulate levels humans remains be determined. Approach Results: By using...