A5100454737- Electrochemical sensors and biosensors
- Advanced biosensing and bioanalysis techniques
- Electrochemical Analysis and Applications
- Cancer-related molecular mechanisms research
- Protein Hydrolysis and Bioactive Peptides
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Pluripotent Stem Cells Research
- Mesenchymal stem cell research
- Galectins and Cancer Biology
- RNA modifications and cancer
- Monoclonal and Polyclonal Antibodies Research
- Ubiquitin and proteasome pathways
- Biochemical effects in animals
- Neuroscience and Neuropharmacology Research
- Renal and related cancers
- Chronic Lymphocytic Leukemia Research
- RNA and protein synthesis mechanisms
- Signaling Pathways in Disease
- Protein Degradation and Inhibitors
- Sexual Differentiation and Disorders
- Kruppel-like factors research
- Advanced Memory and Neural Computing
- Microbial Metabolism and Applications
- Sulfur Compounds in Biology
First People's Hospital of Yunnan Province
2020-2024
Hebei University of Chinese Medicine
2023
First Affiliated Hospital of Anhui Medical University
2023
Anhui Medical University
2023
Kunming University of Science and Technology
2021-2022
Southern University of Science and Technology
2020-2022
Shenzhen Third People’s Hospital
2020-2022
Ruijin Hospital
2022
Shanghai Jiao Tong University
2022
Jiangxi Agricultural University
2020
In this work, an enhanced electrochemiluminescence (ECL) sensor based on gold nanoflower@graphitic carbon nitride polymer nanosheet–polyaniline hybrids (AuNF@g-C3N4–PANI) was prepared for the detection of dapamine (DA). First, bulk g-C3N4 through polymerizing melamine under 600 °C. And then nanosheet obtained by ultrasonication-assisted liquid exfoliation g-C3N4. Finally, polyaniline (PANI) and nanoflowers (AuNFs) were successively formed in situ synthesis method. The resulting...
Characterization of the lung microbiota could lead to a better understanding pathogenesis pulmonary TB. Here, we applied metagenomic shotgun sequencing instead 16S rRNA method characterize using BALF samples sputum.
The increasing incidence of hepatocellular carcinoma (HCC) is a major challenge worldwide.In the past few years, an number studies have suggested that circular RNAs (circRNAs) play important role in development human tumors, including HCC, but our understanding their function still limited.In this study, we investigated differences expression circRNA MAN2B2 (circMAN2B2) tissues and paired normal tissues.We found knockdown circMAN2B2 HCC cell lines Hep-G2 Huh-7 significantly inhibited...
Phycocyanin is an excellent antioxidant with anti-inflammatory effects on which recent studies are growing; however, its specific target remains unclear. Linear tetrapyrrole compounds such as bilirubin have been shown to lead the induction of heme oxygenase 1 expression in vivo, thus achieving and effects. bound internally linear phycocyanobilin a similar structure bilirubin. We speculate that there probably way inducing 1, tissue oxidative stress inflammation can be inhibited, inhibiting...
ABSTRACT Four enzymes, alcalase, neutrase, bromelain and papain, were used individually to hydrolyze proteins in rice residue. The process conditions optimized by response surface methodology (RSM). Under optimal hydrolyzate yields generated with papain 49.3, 56.7, 30.8 16.6%, respectively. Molecular weight distributions of the hydrolyzates analyzed high-performance liquid chromatography. results showed that neutrase alcalase had smaller polypeptides than those papain. Compared alkaline...
Abstract To date, there is no effective therapy for pathological cardiac hypertrophy, which can ultimately lead to heart failure. Bellidifolin (BEL) an active xanthone component of Gentianella acuta ( G. ) with a protective function the heart. However, role and mechanism BEL action in hypertrophy remain unknown. In this study, mouse model was established by isoprenaline (ISO) induction or without treatment. The results showed that alleviated dysfunction changes induced ISO mice. expression...
In this article, a new electrochemiluminescent (ECL) biosensor based on g-C3N4–hemin nanocomposite and hollow gold nanoparticles (HGNPs) was constructed to detect lactate. Firstly, the g-C3N4 nanosheets were prepared through ultrasonication-assisted liquid exfoliation of bulk g-C3N4, which obtained polymerizing melamine under 600 °C. Then, nanocomposites hemin modify glassy carbon electrode. Subsequently, HGNPs self-assembled onto electrode for adsorbing lactate oxidase achieve biosensor....
miR-20a-5p has recently been identified to induce adipogenesis of established adipogenic cell lines in our previous study. However, its role and molecular mechanisms the regulation adipocyte lineage commitment bone marrow-derived stromal cells (BMSCs) still need be explored. In this report, we demonstrated expression was promoted gradually during differentiation BMSCs. We also confirmed that a positive function BMSCs by gain-of-function study with overexpression lentivirus or synthetic...
The preparation process and cathodic electrochemiluminescence behavior of an ammonolysis product 3,4,9,10-perylenetetracarboxylic dianhydride in aqueous solution.
Accumulating evidence has indicated that a group of novel molecules, known as transfer RNA (tRNA)-derived fragments (tRFs) and tRNA halves (tiRNAs), which are derived from tRNAs, serve an essential role in numerous types human disease, particular solid tumors. However, to the best our knowledge, underlying mechanisms effect tRFs tiRNAs lung adenocarcinoma have not been reported. The present study aimed determine differential expression levels adjacent tissues using NextSeq system, further...
Human gastric cancer is a common malignant neoplasm of the digestive system and represents threat to human health worldwide. The mechanisms underlying germination development are not yet fully understood. Circular RNAs (circRNAs) serve crucial roles in various physiological pathological processes, particularly cancer. However, few studies have focused on involving circRNAs Therefore present study set out identify differentially expressed Three specimens normal tissue were selected circRNA...
Icariside II (ICS II) has been reported to have protective effects against oxidative stress. However, whether ICS protects cardiomyocytes from myocardial infarction (MI), and the associated underlying mechanisms, remain be elucidated. Therefore, current study investigated of on hypoxia‑injured H9c2 cells, as well molecular mechanisms. A hypoxic injury model was established emulate MI. The proliferation rat cardiomyocyte cells were assessed with cell counting kit‑8 assays. apoptotic status by...
RING box protein-1 (RBX1) is an essential component of Skp1-cullin-F-box protein (SCF) E3 ubiquitin ligase and participates in diverse cellular processes by targeting various substrates for degradation. However, the physiological function RBX1 mouse oocyte maturation remains unknown. Here, we examined expression, localization during meiotic maturation. Immunofluorescence analysis showed that displayed dynamic distribution process: it localized around migrated along with spindle condensed...
Summary ING2 (inhibitor of growth protein-2) is a member the ING-gene family and participates in diverse cellular processes involving tumor suppression, DNA repair, cell cycle regulation, senescence. As subunit Sin3 histone deacetylase complex co-repressor complex, binds to H3K4me3 regulate chromatin modification gene expression. Additionally, recruits methyltransferase (HMT) activity for repression, which independent HDAC class I or II pathway. However, physiological function mouse...
The mechanism of cisplatin resistance is complex. Previous studies have indicated that chloride voltage-gated channel 3 (CLCN3) associated with drug resistance; however, the mechanisms are not fully understood. Therefore, present study explored involvement CLCN3 in human glioma U251 cells. effects combined treatment and suppression on cultured cells were investigated. decreased viability cisplatin-treated cytotoxic silencing. Expression apoptosis-related gene TP53 caspase activation enhanced...