A5101573472- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Pluripotent Stem Cells Research
- Inflammasome and immune disorders
- RNA Research and Splicing
- Congenital heart defects research
- Porphyrin Metabolism and Disorders
- Icing and De-icing Technologies
- Nuclear Receptors and Signaling
- Atmospheric chemistry and aerosols
- Immune cells in cancer
- Air Quality and Health Impacts
- Sirtuins and Resveratrol in Medicine
- Surface Modification and Superhydrophobicity
- Cancer-related gene regulation
- Lymphoma Diagnosis and Treatment
- RNA and protein synthesis mechanisms
- Per- and polyfluoroalkyl substances research
- Cell death mechanisms and regulation
- DNA Repair Mechanisms
- Chronic Lymphocytic Leukemia Research
- Mesenchymal stem cell research
- Monoclonal and Polyclonal Antibodies Research
- Heme Oxygenase-1 and Carbon Monoxide
- Signaling Pathways in Disease
China Pharmaceutical University
2025
Kunming University of Science and Technology
2021-2024
Southern Medical University
2022
First People's Hospital of Yunnan Province
2021
Chinese University of Hong Kong
2018
Sichuan University
2015
Third Hospital of Hebei Medical University
2008
Hebei Medical University
2008
Gasdermin E (GSDME) is a pyroptotic cell death effector and promising target for tissue injury. Here we perform high-throughput screening demonstrate that methylcobalamin (MeCbl), an endogenous coenzyme form of vitamin B12, specific GSDME inhibitor highly effective against cholestatic liver failure. MeCbl specifically blocks cleavage by directly binding with GSDME. In cholestasis-, cisplatin- or concanavalin A (Con A)-induced male mouse models, significantly suppresses transaminase...
Perfluoroalkyl substances (PFAS) are an emerging class of contaminants that have been produced since the 1950s. The first report on PFAS to raise global concerns was published in 2001. Since then, many countries implemented policies control PFAS. In this study, water, sediment, and biota coastal areas were surveyed review their use earliest production by using chronological methods combined with previous policy restrictions imposed meantime, reports existing evaluated assess ecological...
Accumulating evidence has indicated that a group of novel molecules, known as transfer RNA (tRNA)-derived fragments (tRFs) and tRNA halves (tiRNAs), which are derived from tRNAs, serve an essential role in numerous types human disease, particular solid tumors. However, to the best our knowledge, underlying mechanisms effect tRFs tiRNAs lung adenocarcinoma have not been reported. The present study aimed determine differential expression levels adjacent tissues using NextSeq system, further...
Pyroptosis is a critical type of programmed cell death that strongly associated with the regulation tumor and immune functions. However, role pyroptosis in progression remodeling microenvironment gliomas has not been extensively studied. Thus, this study, we aimed to establish comprehensive pyroptosis-related signature uncover its potential clinical application gliomas.The TCGA glioma cohort was obtained divided into training internal validation cohorts, while CGGA used as an external...
Abstract Susceptible genetic polymorphisms and altered expression levels of protein kinase C (PKC)-encoding genes suggest overactivation PKC in autism spectrum disorder (ASD) development. To delineate the pathological role PKC, we pharmacologically stimulated its activity during early development zebrafish. Results demonstrated that hyper-activation perturbs zebrafish induces a long-lasting head size deficit. The anatomical cellular analysis revealed reduced neural precursor proliferation...
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Transfer RNA-derived fragments (tRFs) are short non-coding RNA (ncRNA) sequences, ranging from 14 to 30 nucleotides, produced through the precise cleavage of precursor and mature tRNAs. While tRFs have been implicated in various diseases, including cancer, their role lung adenocarcinoma (LUAD) remains underexplored. This study aims investigate impact tRF-Val-CAC-010, a specific tRF molecule, on phenotype LUAD cells its tumorigenesis progression vivo. The expression level tRF-Val-CAC-010 was...
Human bone marrow mesenchymal stem cells (h-BMSCs) have the potential to differentiate into dopaminergic neuron-like treat Parkinson’s disease. The Notch signaling pathway has been implicated in regulation of cell fate decisions such as differentiation BMSCs. This study investigated changes expression Notch-related genes BMSCs vitro (DA) cells. transfected with empty lentiviral vectors served control group and those NTN Lmx1α recombinant experimental group. After induction culture...
This study aimed to compare the application value of capillary electrophoresis and next-generation sequencing for immunoglobulin (IG) gene rearrangement in diagnosis classic Hodgkin’s lymphoma. Twenty paraffin-embedded specimens from patients with lymphoma were screened. For detection, ABI 3500 Genetic Analyzer Ion GeneStudio S5 Plus system used, respectively, results compared. Five cases monoclonal rearrangements (25%, 5/20) detected by Capillary Electrophoresis, positivity FR1, FR2, FR3,...