A5049101117- Inflammasome and immune disorders
- Ultrasound and Hyperthermia Applications
- Nanoplatforms for cancer theranostics
- Structural Behavior of Reinforced Concrete
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Concrete Corrosion and Durability
- Immune Response and Inflammation
- Advanced Sensor and Energy Harvesting Materials
- Power Systems and Technologies
- Cancer Immunotherapy and Biomarkers
- Innovative concrete reinforcement materials
- Nanoparticle-Based Drug Delivery
- Gout, Hyperuricemia, Uric Acid
- Conducting polymers and applications
- Autophagy in Disease and Therapy
- Concrete and Cement Materials Research
- Immune Cell Function and Interaction
- Structural Response to Dynamic Loads
- Advanced Computational Techniques and Applications
- Service-Oriented Architecture and Web Services
- IL-33, ST2, and ILC Pathways
- Photoacoustic and Ultrasonic Imaging
- Mobile Agent-Based Network Management
- Bone health and osteoporosis research
Hunan University of Technology
2010-2024
Qilu Hospital of Shandong University
2019-2024
Changzhou No.2 People's Hospital
2012-2024
Nanjing Medical University
2012-2024
Hohai University
2024
Nankai University
2021-2023
Tianjin Medical University Eye Hospital
2023
Tianjin Medical University
2023
Chinese University of Hong Kong
2013-2022
Konkuk University
2013-2022
A recent mutation analysis suggested that Non-Structural Protein 6 (NSP6) of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a key determinant viral pathogenicity. Here, by transcriptome analysis, we demonstrated inflammasome-related NOD-like receptor signaling was activated in SARS-CoV-2-infected lung epithelial cells and Disease 2019 (COVID-19) patients' tissues. The induction inflammasomes/pyroptosis patients with severe COVID-19 confirmed serological markers....
Abstract The cause of insulin insufficiency remains unknown in many diabetic cases. Up to 50% adult patients with cystic fibrosis (CF), a disease caused by mutations the gene encoding CF transmembrane conductance regulator (CFTR), develop CF-related diabetes (CFRD) most exhibiting insufficiency. Here we show that CFTR is glucose-dependent electrical acitivities and secretion β-cells. We demonstrate glucose elicited whole-cell currents, membrane depolarization, bursts or action potentials, Ca...
Immunotherapy had demonstrated inspiring effects in tumor treatment, but only a minority of people could benefit owing to the hypoxic and immune-suppressed microenvironment (TME). Therefore, there was an urgent need for strategy that relieve hypoxia increase infiltration lymphocytes simultaneously. In this study, novel acidity-responsive nanoscale ultrasound contrast agent (L-Arg@PTX nanodroplets) constructed co-deliver paclitaxel (PTX) L-arginine (L-Arg) using homogenization/emulsification...
LH signaling is required for oocyte maturation in fish and other vertebrates. However, the downstream factors mediating are largely unexplored fish. In this study, we investigated whether IGFs could mediate action on zebrafish. Our results show that all igfs, including igf1, igf2a, igf2b, igf3, dynamically expressed during folliculogenesis, with expression of igf3 reaching its maximal level full grown stage follicles. The igfs regulated by through a cAMP pathway intact follicles as well...
Hydrogels are ideal materials for flexible electronic devices based on their smooth ion channels and considerable mechanical flexibility. A substantial volume of aqueous solution is required to enable the flow ions, resulting in agony low-temperature freezing; besides, long-term exposure bending/tensile tress triggers fatigue issues. Therefore, it a great challenge prepare hydrogels with both freeze-resistance durability. Herein, polyacrylic acid-based hydrogel hydrophobic interaction...
The inhibition of autophagy is a feasible clinical strategy in tumor therapy. Traditional inhibitors are limited therapy due to nonspecific biodistribution, systemic toxicity and antitumor effect. Herein, the inhibitor hydroxychloroquine (HCQ)-loaded nanodroplets (NDs) synthesized overcome these drawbacks. HCQ-NDs endowed with endogenous pH- exogenous ultrasound-responsive drug release contrast enhanced ultrasound imaging performance. combined application ultrasound-targeted microbubble...
Aim: O-carboxymethyl chitosan/perfluorohexane nanodroplets (O-CS NDs) and doxorubicin-loading chitosan were synthesized functionally tested as drug delivery system in vitro. Materials & methods: The characteristics, charge conversion, stability, cytotoxicity, ultrasound imaging ability, interaction with tumor cells of the eradication on doxorubicin-loaded investigated. Results: O-CS NDs (below 200 nm) achieved higher cellular associations at acidic pH, great serum pH-dependent conversion...
Ophiocordyceps sinensis (C. sinensis) extracts have been found to a therapeutic effect on patients with chronic obstructive pulmonary disease (COPD). Silent information regulator 1 (SIRT1) plays an important role in the regulation of inflammatory mediators and correlates lung function COPD exacerbations. The objective this work was explore anti-inflammatory preliminary pathways nucleosides from cultured C. RAW264.7 macrophages mice.The were extracted powder further purified by macroporous...
Abstract Chemoprevention is cost-effective for colorectal cancer when targeted at intermediate- or high-risk populations. Bufalin a cardiac glycoside extracted from the traditional Chinese medicine (TCM) “Chan Su,” which has been used as an anticancer agent. On basis of relative safety bufalin, we investigated whether bufalin could act chemoprophylactic agent to prevent colon tumorigenesis in two murine models, namely colitis-associated and Apc germline mutation-developed cancer. Our results...
Abstract As a potential drug/gene delivery system, the ultrasound-targeted microbubble destruction (UTMD) system can be used as vehicle well increasing permeability of biological barriers to enhance effect tumor treatment. However, UTMD in EMT process is unknown. In this study, we aimed investigate and mechanism induced oxidative stress inhibiting breast cancer. Human MDA231 cells were treated with (MB), ultrasound (US) UTMD, respectively. The generation stress, levels miR-200c, ZEB1...
Multiple drug resistance (MDR) exists in divergent cancers including triple negative breast cancer (TNBC) and partly results the to many first-line anti-cancer agents, bringing a big challenge TNBC management. To develop novel therapeutics, our study, hyaluronic acid (HA)–carboxymethyl chitosan (CMC) conjugate linked via disulfide-bond (HA-SS-CMC, HSC) was synthesized fabricate nanodroplets (NDs). The NDs encapsulating doxorubicin (DOX) perfluorohexane (DOX-HSC-NDs) were prepared...
Abstract As the largest proportion of myeloid immune cells in tumors, macrophages play an important role tumor growth and regression according to their different phenotypes, thus reprogramming has become a new research direction for cancer immunotherapy. Yeast-derived whole β-glucan particles (WGPs) can induce M0 differentiate into M1 convert M2 tumor-associated (TAMs) macrophages. In vitro, studies have confirmed that WGP-treated increase activating receptors natural killer (NK cells)...
Synergistic chemoradiotherapy (CRT) has become a primary effective curative approach for many solid cancers. However, CRT is still associated with several obstacles, including the increases in side effects and systemic toxicity. Incorporating nanocarriers into new exciting to solve these obstacles. The purpose of present study was design unique pH- ultrasound-responsive perfluoropentane-encapsulated, paclitaxel (PTX)-loaded carboxymethyl chitosan nanodroplets (NDs) combined imaging...
Background The tumor microenvironment (TME) contains a variety of immune cells, which play critical roles during the multistep development tumors. Histone deacetylase 9 (HDAC9) has been reported to have either proinflammatory or anti-inflammatory effects, depending on environment. In this study, we investigated whether HDAC9 in stroma regulated inflammation and antitumor immunity. Methods Hdac9 knockout mice were generated analyze HDAC9-associated progression. Immune cells cytokines TME...
The construction of multifunctional oncotherapy nanoplatforms that combine diagnosis and treatment remains challenging. Nanodroplets (NDs), which simultaneously enhance ultrasound imaging therapeutic effects, are a potential strategy for non-invasive drug delivery. To achieve the goals precise medicine, novel SP94 peptide-modified doxorubicin-loaded ultrasonic NDs (SP94-DOX-NDs) castration-resistant prostate cancer (CRPC) targeting were constructed in this study. characteristics,...
Triple-negative breast cancer (TNBC) is known to be the most aggressive form of cancer. Due its high recurrence and mortality rates, treatment TNBC a significant challenge for medical community. Besides, ferroptosis an emerging regulatory cell death that may provide new insights into TNBC. As central inhibitor process, selenoenzyme glutathione peroxidase 4 (GPX4) classical therapeutic target. However, inhibition GPX4 expression quite detrimental normal tissues. Ultrasound contrast agents, as...