A5103057655- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Tryptophan and brain disorders
- MicroRNA in disease regulation
- Gastrointestinal Tumor Research and Treatment
- Circular RNAs in diseases
- Immune Cell Function and Interaction
- Thyroid Cancer Diagnosis and Treatment
- Immune cells in cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Breast Cancer Treatment Studies
- Cancer Risks and Factors
- Cancer Cells and Metastasis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ovarian cancer diagnosis and treatment
- Stress Responses and Cortisol
- Thyroid and Parathyroid Surgery
- Advanced biosensing and bioanalysis techniques
- Cancer, Lipids, and Metabolism
- Cancer-related cognitive impairment studies
- Radiomics and Machine Learning in Medical Imaging
- Inflammatory Biomarkers in Disease Prognosis
- Nanoplatforms for cancer theranostics
Qilu Hospital of Shandong University
2023-2024
Tianjin Medical University Cancer Institute and Hospital
2013-2024
Chongqing Medical University
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
China Academy of Railway Sciences
2023
Tianjin Medical University General Hospital
2022
National Clinical Research
2014-2022
Center for Cancer Research
2022
Nanjing Agricultural University
2022
National Clinical Research Center for Digestive Diseases
2017-2021
Background: Regulatory T cells(Tregs) and myeloid-derived suppressor cells(MDSCs) represent two immunosuppressive cell populations that are important in the establishment maintenance of cancer immune tolerance. MDSCs can express IDO promote tolerance via expansion Treg cell.Method: We use needle biopsy breast tissues prior to neoadjuvant chemotherapy(NCT) staining for CD33, Foxp3 by immunohistochemistry evaluate whether they were correlated with subsequent treatment responses cancer.Results:...
Recent studies have shown that competing endogenous RNAs (ceRNAs) play an important role in the regulation of gene expression, and participate a wide range biological processes, including carcinogenesis. Long non-coding RNA PTENP1, pseudogene PTEN tumor suppressor, has been reported to exert its suppressive function via modulation expression many malignancies. However, whether PTENP1~miRNA~PTEN ceRNA network exists how it functions gastric cancer (GC) remains elusive. In order identify...
Abstract Background The tumor microenvironment represents an abnormal niche containing numerous factors, such as T cells, dendritic cells (DCs), regulatory (Tregs), and indoleamine 2,3‐dioxygenase (IDO), involved in maintaining immune homeostasis tolerance. All these factors may influence the choice of therapy clinical outcomes. Methods Flow cytometry was performed to identify CD4+/CD8 + DCs, immunohistochemistry used evaluate IDO Forkhead Box P3 (Foxp3) expression; experiments were order...
Indoleamine 2, 3-dioxygenase (IDO), which catalyzes the breakdown of essential amino acid tryptophan into kynurenine, is understood to have a key role in cancer immunotherapy. IDO has also received more attention because its non-immune functions including regulating angiogenesis. The purpose this study was investigate effects on microvessel density, and explore prognostic breast cancer. We showed expression positively correlated with density (MVD) labeled by CD105 (MVD-CD105) rather than MVD...
Background: Metabolic syndrome(MetS) play a carcinogenic role in variety of cancers and influence the prognosis cancer patients both systemically hormonally. Methods: The data clinicopathologic features MetS 808 gastric 1146 randomly healthy controls were analyzed retrospectively. Results: Higher TG level, lower HDL-C level higher hypertension frequency observed all when compared with controls. While, had greater waist circumference only females. Among three definitions MetS, identified by...
The AURELIA trial demonstrated that adding Bevacizumab to chemotherapy significantly improved progression-free survival (PFS) for platinum resistant recurrent ovarian cancer. Recently, immunotherapy also presented potential anti-tumor effects in several malignant solid tumors. This study aimed investigate whether combining anti-PD-L1 Atezolizumab with BEV may have a synergistic effect and enhance the efficacy of both treatments cisplatin epithelial cancer (CREOC). We retrospectively analyzed...
Ovarian cancer (OC) is a malignant tumor that seriously affects women's health. In recent years, immunotherapy has shown great potential in treatment. As major contributor of immunotherapy, dendritic cells (DCs) - based vaccine been demonstrated to have positive effect inducing immune responses animal experiments. However, the vaccines clinical trials not ideal. Therefore, it urgent improve existing for Here, we developed fusion cell membrane (FCM) nano-vaccine FCM-NPs, which prepared by...
Background: There was few study concentrated on the correlation between evaluated tumor markers and lymph node metastasis. In this study, we aimed to evaluate CA724, CA242, CA199, CEA metastasis of gastric cancer assess prognostic value them in different N stage patients.Methods: We analyzed serum level 1501 patients.Results: Lymph related with location, Bormann type, size, histological depth invasion TNM (p < 0.05). The values CA199 were positively correlated metastatic counts later was,...
Introduction: Photodynamic therapy (PDT) has been widely researched by cancer therapists in recent years. This study aims to establish a drug delivery system combining PDT and chemotherapy show that chemotherapeutic drugs provide oxygen PDT, while promotes the release of drug. Methods: Firstly, poly(ethylene glycol)-lysine(Ce6)-block-poly(L-glutamate)-imidazole (mPEG-lys(Ce6)-PGA-AIM) was synthesized self-assembled into micelles exhibited pH- ROS-responsiveness buffering capacity....
Abstract Background The aim of this study was to explore the correlation between biomarkers lipid metabolism and gastric cancer. Methods 1120 cancer patients 1134 health examiners enrolled in study. clinic data serum level, including Total cholesterol (TC), Triglyceride (TG), Low-density lipoprotein (LDL-C) High-density (HDL-C), were collected. Results Serum TG LDL-C levels with higher than those control group. HDL-C lower group ( P < 0.05). significantly correlated risk Concentrating on...
Abstract Purpose To explore the time and pattern of recurrence proximal gastric cancer estimate risk factors prognostic for it. Considering these factors, postoperative adjuvant therapies follow‐up program can be individualized. Methods The data 135 patients were extracted analyzed. Results In patients, median to was 14.0 months, 116 (85.9%) had recurrences within 2 years. Loco‐regional most prevalent pattern. Hematogenous metastasis next in which liver common organ. Peritoneal occurred 32...
We aimed to study the relationship between thrombocytosis and clinical features of gastric cancer focussing on platelet counts progression through different TNM stages.According normal range count in our institution, 1,596 patients were divided two groups: a group (120 patients, >400?1000/μL) control (1,476 ≤400?1000/μL).The incidence was 7.5%. Higher observed with older age, larger tumor size, deeper invasion, lymph node metastasis, distant metastasis advanced stage. In multivariate...
Several researches revealed that propofol, a hypnotic intravenous anesthesia agent, could inhibit the cancer cell proliferation and tumor formation, which might affect recurrence or metastasis impact patients’ prognosis. Cancer stem cells (CSCs) comprised tiny fraction of bulk played vital role in eventual mortality. This study investigates effect propofol on breast (BCSCs) vitro underlying molecular mechanisms. Tumor formation CSCs was measured by mammosphere culture. Cultured BCSCs were...
Bosniak classification system provides a fine imaging evaluation for the malignant cystic renal masses. Superb microvascular (SMI) is new ultrasonic technique which apply advanced clutter suppression to reflect microflow information. The aim of this study was evaluate performance ultrasound aided by SMI in diagnosis masses.By comparing with contrast-enhanced (CEUS) and pathology, we evaluated sensitivity, specificity accuracy conventional combination masses.Color Doppler Flow image (CDFI)...
Secretory breast carcinoma (SBC) is a rare type of malignancy, accounting for less than 0.02% all infiltrating malignancies. The pure SBC, SBC without another malignant neoplasm, particularly rare. This study aimed to investigate the clinicopathologic and molecular features SBC.The main pathological parameters such as estrogen receptor (ER), progesterone (PR), human epithelial growth factor 2 (C-erbB-2) were detected by immunohistochemistry (IHC), prognostic difference compared with invasive...