A5101657637- Cancer-related molecular mechanisms research
- Cancer, Stress, Anesthesia, and Immune Response
- Renal cell carcinoma treatment
- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- RNA Research and Splicing
- Anesthesia and Sedative Agents
- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- Cancer-related gene regulation
- Anesthesia and Neurotoxicity Research
- Cancer-related Molecular Pathways
- Renal and related cancers
- Anesthesia and Pain Management
- Cancer Research and Treatments
- Advanced Proteomics Techniques and Applications
- Cell death mechanisms and regulation
- Bioactive Natural Diterpenoids Research
- Neurological Disease Mechanisms and Treatments
- Dental Radiography and Imaging
- Cardiac Ischemia and Reperfusion
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
Binzhou Medical University
2024
Yuhuangding Hospital
2013-2024
Qingdao University
2012-2024
Binzhou University
2024
Tianjin Medical University General Hospital
2015-2024
Shanxi Provincial Cancer Hospital
2011-2024
Peking University
2023
Chengdu Medical College
2023
Tianjin Medical University Cancer Institute and Hospital
2009-2022
Jilin University
2021
The study aimed to evaluate the accuracy of perineural invasion (PNI) diagnosis in cervical cancer, and analyze impact PNI on prognosis postoperative adjuvant treatment decisions for cancer.
Cisplatin (DDP) is the first-line chemotherapeutic agent against lung cancer. However, therapeutic effect of DDP loses over time due to acquired drug resistance in non-small cell cancer (NSCLC) cells. In recent years, role traditional Chinese medicine (TCM) cordycepin (Cor) treatment has been attracting attention. effects Cor on NSCLC are unclear. present study, we aimed investigate combination with proliferation and apoptosis explore possible underlying mechanisms. The were analyzed...
BackgroundImproved markers for predicting recurrence are needed to stratify patients with localised (stage I–III) renal cell carcinoma after surgery selection of adjuvant therapy. We developed a novel assay integrating three modalities—clinical, genomic, and histopathological—to improve the predictive accuracy recurrence.MethodsIn this retrospective analysis validation study, we histopathological whole-slide image (WSI)-based score using deep learning allied digital scanning conventional...
ZEB2 has been reportedly shown to mediate the epithelial-to-mesenchymal transition (EMT) and disease aggressiveness in human tumors. However, expression status of renal cell carcinoma (RCC) ZEB2's clinicopathologic/prognostic significance are poorly understood.In this study, tissue microarray, immunohistochemistry (IHC) western blot analyses were utilized investigate RCC adjacent samples. In our samples from 116 patients treated with radical nephrectomy used as a training set generate...
Objectives: The pectoral nerves (Pecs) II block is a technique that places local anesthetic between the thoracic muscles to axillary and breast regions. This study aimed compare quality of perioperative analgesia side effects Pecs under general anesthesia versus alone in immediate unilateral reconstruction with an implant latissimus dorsi flap after modified radical mastectomy. Materials Methods: Sixty-four patients scheduled for mastectomy were randomly allocated into group (group P, n=32)...
Abstract Alternative splicing is emerging as an oncogenic mechanism. In prostate cancer, generation of constitutively active forms androgen receptor (AR) variants including AR-V7 plays important role in progression castration-resistant cancer (CRPC). generated by alternative that results inclusion cryptic exon CE3 and translation truncated AR protein lacks the ligand binding domain. Whether can be a driver for CRPC remains controversial mechanism activation elusive. Here, we found KDM4B...
Abstract Aberrant expression of miRNAs in pancreatic islets is closely related to the development type 1 diabetes (T1D). The aim this study was identify key dysregulated during T1D progression and develop a theranostic approach modify their using an MRI-based nanodrug consisting iron oxide nanoparticles conjugated miRNA-targeting oligonucleotides mouse model T1D. Isolated were derived from NOD mice three distinct age groups (3, 8 18-week-old). Total RNA collected cultured purified global...
Traumatic brain injury (TBI) persists as a substantial clinical dilemma, largely because of the absence effective treatments. This challenge is exacerbated by hindered clearance intracranial metabolic byproducts and continual accrual deleterious proteins. The glymphatic system (GS) meningeal lymphatic vessels (MLVs), key elements network, play critical roles in harmful substances. Cannabidiol (CBD) has shown promise reducing metabolite overload bolstering cognitive performance various...
Abstract Integrating genomics and histology for cancer prognosis demonstrates promise. Here, we develop a multi-classifier system integrating lncRNA-based classifier, deep learning whole-slide-image-based clinicopathological classifier to accurately predict post-surgery localized (stage I–III) papillary renal cell carcinoma (pRCC) recurrence. The significantly higher predictive accuracy recurrence-free survival (RFS) compared the three single classifiers alone in training set both validation...
Previous studies have demonstrated that the benzo[c]phenanthridine alkaloid chelerythrine chloride (CC) has inhibitory effects on various tumors. However, anticancer activity of CC and its underlying mechanisms not been elucidated in renal cancer cells. The present study examined growth inhibition apoptosis cells vitro vivo. Flow cytometry 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays revealed markedly suppressed HEK‑293 human SW‑839 a time- dose‑dependent manner....
Several researches revealed that propofol, a hypnotic intravenous anesthesia agent, could inhibit the cancer cell proliferation and tumor formation, which might affect recurrence or metastasis impact patients’ prognosis. Cancer stem cells (CSCs) comprised tiny fraction of bulk played vital role in eventual mortality. This study investigates effect propofol on breast (BCSCs) vitro underlying molecular mechanisms. Tumor formation CSCs was measured by mammosphere culture. Cultured BCSCs were...
He-Chan Pian (HCP), a traditional Chinese medicinal formula, shows promising efficacy for the treatment of lung cancer.Gremlin (GREM1) plays an important role in gastrointestinal tumor metastasis; however, little is known about its cancer. We determined mechanism underlying protective effect HCP against metastasis mouse model non-small cell cancer (NSCLC) and demonstrated GREM1.Ultra-high performance liquid chromatography-mass spectrometry (UPLC-MS) was used to analyze herbal components...
Raltitrexed (RTX) is an antimetabolite drug used as a chemotherapeutic agent for treating colorectal cancer, malignant mesothelioma, and gastric cancer. The antitumor capacity of RTX attributed to its inhibitory activity on thymidylate synthase (TS), key enzyme in the synthesis DNA precursors. current study aimed at investigating potential effects liver Using HepG2 cell line vitro model we evaluated proliferation employing both WST-8 assay clone formation efficiency assay. In addition,...
<h3>Objective:</h3> We tested the hypothesis that dopamine-dependent motor learning mechanism underlies long-duration response to levodopa in Parkinson disease (PD) based on our studies a mouse model. By data-mining task performance dominant and nondominant hands of subjects double-blind randomized trial therapy, effects activity dopamine therapy were examined. <h3>Methods:</h3> data-mined Earlier versus Later Levodopa Therapy Parkinson9s Disease (ELLDOPA) study published 2005 performed...
The involvement of S100A4 in modulating invasiveness esophageal squamous cell carcinoma (ESCC) lines was explored. It shown that expression is positively correlated with the degree human ESCC cells. S100A4-rich EC-1 cells displayed higher migratory and invasive behavior while ET-1 low levels lower behavior. silencing by small interfering (siRNA) induced E-cadherin expression, overexpression a lowly TE-1 suppressed expression. suggested inhibit invasion via upregulation, promote...
There is significant variability with respect to the prognosis of nonmetastatic clear cell renal carcinoma (ccRCC) patients venous tumor thrombus (VTT). By applying multiregion whole-exome sequencing on normal-tumor-thrombus-metastasis quadruples from 33 ccRCC patients, we showed that metastases were mainly seeded by VTT (81.8%) rather than primary tumors (PTs). A total 706 three independent cohorts included in this study. C-index analysis revealed pathological grading outperformed other...
Eukaryotic translation initiation factor (EIF) 5A2 exerts important functions that regulate the development and progression of cancers. The present study aimed to investigate expression EIF5A2 in prostate cancer (PCa) its association with biological prognostic significance. mRNA protein levels were analyzed three paired samples freshly resected PCa adjacent non-tumor tissues. Immunohistochemical staining was used detect 72 paraffin-embedded tumor specimens. Subsequently, between...