A5100775429- Ferroptosis and cancer prognosis
- Renal cell carcinoma treatment
- Tryptophan and brain disorders
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- HIV-related health complications and treatments
- Bladder and Urothelial Cancer Treatments
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Urinary and Genital Oncology Studies
- Cryptography and Data Security
- Prostate Cancer Treatment and Research
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Complexity and Algorithms in Graphs
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Prostate Cancer Diagnosis and Treatment
- RNA Research and Splicing
- Privacy-Preserving Technologies in Data
- Renal and related cancers
- MRI in cancer diagnosis
- Urological Disorders and Treatments
The First Affiliated Hospital, Sun Yat-sen University
2017-2024
Sun Yat-sen University
2012-2024
Jiangxi University of Traditional Chinese Medicine
2023
Xichang University
2020
Southern Medical University
2015
Shaanxi Normal University
2012-2015
Abstract Sunitinib resistance remains a serious challenge to the treatment of advanced and metastatic renal cell carcinoma (RCC), yet mechanisms underlying this are not fully understood. Here, we report that long noncoding RNA IGFL2-AS1 is driver therapy in RCC. was highly upregulated sunitinib-resistant RCC cells associated with poor prognosis patients clear (ccRCC) who received sunitinib therapy. enhanced TP53INP2 expression by competitively binding hnRNPC, multifunctional RNA-binding...
Abstract Background N6-methyladenosine (m6A) related long noncoding RNAs (lncRNAs) may have prognostic value in bladder cancer for their key role tumorigenesis and innate immunity. Methods Bladder transcriptome data the corresponding clinical were acquired from Cancer Genome Atlas (TCGA) database. The m6A-immune-related lncRNAs identified using univariate Cox regression analysis Pearson correlation analysis. A risk model was established least absolute shrinkage selection operator (LASSO)...
Abstract High lymphocyte infiltration and immunosuppression characterize the tumor microenvironment (TME) in renal cell carcinoma (RCC). There is an urgent need to elucidate how cells escape immune attack develop novel therapeutic targets enhance efficacy of checkpoint blockade (ICB) RCC. Overactivated IFN‐ γ ‐induced JAK/STAT signaling involves such TME, but underlying mechanisms remain elusive. Here, EH domain‐binding protein 1‐like 1 (EHBP1L1) identified as a crucial mediator...
Abstract Circular RNAs (circRNAs) play critical roles in clear cell renal carcinoma (ccRCC). However, their involvement sunitinib resistance remains largely unknown. Herein, we identified a novel circRNA, named circME1, which contributes to development ccRCC. CircME1 also promoted proliferation, migration, and invasion of ccRCC cells. Further mechanism analysis showed that circME1 interacted with U1 snRNP at the promoter its parental gene ME1, thereby upregulating expression enhancing...
Clear cell renal carcinoma (ccRCC) is a highly invasive and metastatic subtype of kidney malignancy correlated with metabolic reprogramming for adaptation to the tumor microenvironment comprising infiltrated immune cells immunomodulatory molecules. The role in (TME) their association abnormal fatty acids metabolism ccRCC remains poorly understood. RNA-seq clinical data KIRC from Cancer Genome Atlas (TCGA) E-MTAB-1980 ArrayExpress dataset. Nivolumab group Everolimus CheckMate 025 study,...
Abstract Clear cell renal carcinoma (ccRCC), the most common subtype of carcinoma, can easily invade local tissues and metastasize, is resistant to currently available treatments. Recent studies profiling microRNA expression in ccRCC have suggested miR-30a-5p may be deregulated these cancer cells. To determine its role mechanism action ccRCC, miR-30-5p levels were quantified functions analyzed using vitro vivo experiments bioinformatics. A decrease was frequently noted cells tissues....
Abstract Alternative splicing is emerging as an oncogenic mechanism. In prostate cancer, generation of constitutively active forms androgen receptor (AR) variants including AR-V7 plays important role in progression castration-resistant cancer (CRPC). generated by alternative that results inclusion cryptic exon CE3 and translation truncated AR protein lacks the ligand binding domain. Whether can be a driver for CRPC remains controversial mechanism activation elusive. Here, we found KDM4B...
The tumor microenvironment (TME) in renal cell carcinomas (RCC) is marked by substantial immunosuppression and immune resistance despite having extensive T-cell infiltration. Elucidation of the mechanisms underlying evasion could help identify therapeutic strategies to boost efficacy checkpoint blockade (ICB) RCC. This study uncovered a mechanism wherein polyadenylate-binding protein PABPC1L modulates indoleamine 2,3-dioxygenase 1 (IDO1), prospective target for immunotherapy. was markedly...
To examine the role of miR-106b-5p in regulating cancer stem-cell-like phenotype clear cell renal carcinomas (ccRCC).Real-time PCR was performed to evaluate levels ccRCC lines and patients specimens. A series vivo vitro assays were confirm effect on stemness phenotype.ccRCC cells tissues expressed more than normal controls. Gain- loss-of-function studies demonstrated that overexpression increased spheres formation ability proportion side population cells. Ectopic expression tumour growth...
Abstract Long noncoding RNAs (lncRNAs) have been reported to exert important roles in tumors, including clear cell renal carcinoma (ccRCC). PVT1 is an oncogenic lncRNA which has critical effects on onset and development of various cancers, however, the underlying mechanism functioning ccRCC remains largely unknown. VHL deficiency-induced HIF2α accumulation one major factors for ccRCC. Here, we identified potential molecular promoting by stabilizing HIF2α. was significantly upregulated...
Immune checkpoint inhibitor (ICI) therapy improves the survival of patients with advanced bladder cancer (BLCA); however, its overall effectiveness is limited, and many still develop immunotherapy resistance. The leucine-rich repeat fibronectin type-III domain-containing protein (LRFN) family has previously been implicated in regulating brain dysfunction; mechanisms underlying effect LRFN2 on tumor microenvironment (TME) remain unclear.Here we combined bulk RNA sequencing, single-cell...
Abstract Background Urolithiasis with high prevalence and recurrence rate, has impacts on kidney injury in patients, becomes a socioeconomic healthcare problem worldwide. However, the biology of crystal formation proximal tubular remains essentially unclear. The present study aims to evaluate cell immune-communications urolithiasis mediated injury, provide new insights stone treatment prevention. Results We identified 3 distinct injured-proximal types based differentially expression markers...
We previously identified the important role of RIN 1 expression in prognosis clear cell renal carcinoma (cc RCC ). The cc malignancy and underlying molecular mechanisms remain unclear. Here we report that cells tissues expressed more than normal controls. Gain‐of‐function loss‐of‐function studies demonstrated enhanced growth, migration invasion abilities vitro promoted tumor growth metastasis vivo . Mechanistic revealed has an activating effect on EGFR signaling In addition, unveil Rab25, a...
Eukaryotic translation initiation factor (EIF) 5A2 exerts important functions that regulate the development and progression of cancers. The present study aimed to investigate expression EIF5A2 in prostate cancer (PCa) its association with biological prognostic significance. mRNA protein levels were analyzed three paired samples freshly resected PCa adjacent non-tumor tissues. Immunohistochemical staining was used detect 72 paraffin-embedded tumor specimens. Subsequently, between...
Abstract Purpose There are undetectable levels of fat in fat-poor angiomyolipoma. Thus, it is often misdiagnosed as renal cell carcinoma. We aimed to develop and evaluate a multichannel deep learning model for differentiating angiomyolipoma (fp-AML) from carcinoma (RCC). Methods This two-center retrospective study included 320 patients the First Affiliated Hospital Sun Yat-Sen University (FAHSYSU) 132 Cancer Center (SYSUCC). Data at FAHSYSU were divided into development dataset (n = 267)...
The aim of this study was to investigate the prognostic effect amplified in AIB1 and EIF5A2 expression on postoperative intravesical recurrence for upper urinary tract urothelial carcinoma (UTUC) improve risk stratification prediction chemotherapy benefit.We evaluated immunohistochemical 109 UTUC patients determine predictive significance recurrence. A model developed based univariate multivariate analyses.Intravesical occurred 18 out (16.5%) during follow-up period. Significant associations...
With the rapid development of mobile devices and wireless technologies, social networks become increasingly available. People can implement many applications on basis networks. Secure computation, like exchanging information file sharing, is one such applications. Fairness in secure which means that either all parties application or none them does, deemed as an impossible task traditional computation without Here we regard specific functions stress achievement fairness these within presence...
Prophylactic intravesical chemotherapy can decrease bladder cancer recurrence rate after nephroureterectomy for upper tract urothelial carcinoma. We aimed to compare the effect of different prophylactic regimens in recurrence-free survival. From 2000 2016, a total 270 patients treated with radical at both institutions were enrolled. Patients divided into 3 groups: multiple-instillation group, single-instillation and no-instillation group. Univariable multivariable analyses Cox regression...
ABSTRACT Broadcast encryption is an effective way to broadcast a message securely such that more than one privileged receiver can decrypt it. The well‐known constructions of identity‐based only support bounded users had deploy the maximum user number in advance. This somewhat inefficient and impractical if predetermined. In this paper, we propose adaptively secure standard model supports arbitrary set, which eliminates size public parameters with constant group elements obtain short...
Aim: To study the expression of EIF5A2 in urinary tract urothelial carcinoma and its clinicopathological features prognosis. Methods: was detected via immunohistochemistry 101 patients. Results: Kaplan-Meier analysis showed that low group had significantly longer overall survival (OS; p < 0.001) progression-free (PFS; than high group. The predict poor OS PFS subset patients (p 0.05). an independent prognostic factor for = 0.003 0.001). established nomogram model calibration curve predicted...
Immune checkpoint inhibitors (ICI) have been shown to improve overall survival (OS) in clear cell renal carcinoma (ccRCC) patients. However, less than half of the ccRCC patients objective response ICI.We aim assess role DDX39B predicting patients'OS and ICI therapy response.DDX39B was detected by immunohistochemistry a tissue microarray 305 its relationship with prognosis were also evaluated TCGA set RECA-EU set. The expression analysed two datasets treated ICI.Overexpression predicted poor...