A5100628338- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Tryptophan and brain disorders
- Cancer Immunotherapy and Biomarkers
- HIV-related health complications and treatments
- Renal cell carcinoma treatment
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Cancer Mechanisms and Therapy
- Wnt/β-catenin signaling in development and cancer
- Bladder and Urothelial Cancer Treatments
- Microtubule and mitosis dynamics
- Histone Deacetylase Inhibitors Research
- Galectins and Cancer Biology
- Ubiquitin and proteasome pathways
- Protein Tyrosine Phosphatases
- Renal and related cancers
- Cancer Cells and Metastasis
- Biochemical and Molecular Research
Sun Yat-sen University
2016-2025
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
Shandong First Medical University
2025
Ningxia Medical University
2021-2025
Lanzhou University
2023-2024
Tarim University
2024
Harbin Medical University
2023-2024
Air Force Medical University
2021-2024
Lanzhou University Second Hospital
2023
Sun Yat-sen University Cancer Center
2013-2023
Abstract Circular RNAs (circRNAs) have been implicated in cancer progression through largely unknown mechanisms. Herein, we identify an N 6 -methyladenosine (m A) modified circRNA, circNSUN2, frequently upregulated tumor tissues and serum samples from colorectal carcinoma (CRC) patients with liver metastasis (LM) predicts poorer patient survival. The expression of circNSUN2 promotes LM PDX models vivo accelerates cells invasion vitro. Importantly, modification increases export to the...
Long non-coding RNAs (lncRNAs) are involved in the pathology of various tumors, including colorectal cancer (CRC). However, role lncRNA CRC liver metastasis remains unclear. Methods: a microarray was performed to identify differentially expressed lncRNAs between tissues with and without metastasis. Survival analysis evaluated using Kaplan-Meier method assessed log-rank test. In vitro vivo assays were preformed explore biological effects cells. Results: UICLM (up-regulated metastasis)...
The adenomatous polyposis coli (APC) gene plays a pivotal role in the pathogenesis of colorectal carcinoma (CRC) but remains challenge for drug development. Long noncoding RNAs (lncRNAs) are invaluable identifying cancer pathologies and providing therapeutic options patients with cancer. Here, we identified lncRNA (lncRNA-APC1) activated by APC through microarray screening examined its expression large cohort CRC tissues. A decrease lncRNA-APC1 was positively associated lymph node and/or...
Currently, nasopharyngeal carcinoma (NPC) prognosis evaluation is based primarily on the TNM staging system. This study aims to identify prognostic markers for NPC.We detected expression of 18 biomarkers by immunohistochemistry in NPC tumors from 209 patients and evaluated association between gene level disease-specific survival (DSS). We used support vector machine (SVM)--based methods develop a classifier (NPC-SVM classifier). Further validation NPC-SVM was performed an independent cohort...
Dysregulation of non-coding RNAs, including miRNAs and lncRNAs has been reported to play vital roles in gastric cancer (GC) carcinogenesis, but the mechanism involved is largely unknown. Using genome atlas (TCGA) data set bioinformatics analyses, we identified miR-532-5p as a potential tumor suppressor GC, found that lncRNA LINC01410 might be negative regulator miR-532-5p. We then conducted series vivo vitro assays explore effect on miR-532-5p-mediated GC malignancy underlying involved....
Nasopharyngeal carcinoma (NPC) has the highest metastatic potential among head and neck cancers. Distant metastasis is major cause of treatment failure. The role interleukin-8 (IL-8) in NPC progression remains unknown. Our multivariate survival analyses 255 patients with revealed that higher IL-8 expression primary tissue was an independent prognostic factor for overall survival, disease-free distant metastasis-free patients. In vitro study highly expressed established high-metastasis clone...
Yes-associated protein 1 (YAP 1), the nuclear effector of Hippo pathway, is a key regulator organ size and candidate human oncogene in multiple tumors. However, expression dynamics YAP urothelial carcinoma bladder (UCB) its clinical/prognostic significance are unclear.In this study, methods quantitative real-time polymerase chain reaction (qRT-PCR), Western blotting immunohistochemistry (IHC) were utilized to investigate mRNA/ UCBs. Spearman's rank correlation, Kaplan-Meier plots Cox...
There is increasing evidence that circular RNAs (circRNAs) have significant regulatory roles in cancer development and progression; however, the expression patterns biological functions of circRNAs renal cell carcinoma (RCC) remain largely elusive. Bioinformatics methods were applied to screen for differentially expressed RCC. Analysis online microarray datasets our own patient cohort indicated circSDHC (hsa_circ_0015004) had a potential oncogenic role Subsequently, was measured RCC tissues...
Enhanced aerobic glycolysis constitutes an additional source of energy for tumor proliferation and metastasis. Human papillomavirus (HPV) infection is the main cause cervical cancer (CC); however, associated molecular mechanisms remain poorly defined, as does relationship between CC glycolysis. To investigate whether HPV 16/18 E6/E7 can enhance in CC, expression was knocked down SiHa HeLa cells using small interfering RNA (siRNA). Then, glucose uptake, lactate production, ATP levels,...
Chemoresistance is one of the leading causes therapeutic failure in gastric cancer (GC) treatment. Recent studies have shown lncRNAs play pivotal roles regulating GC chemoresistance. Nanocarriers delivery small interfering RNAs (siRNAs) to silence cancer-related genes has become a novel approach treatment research. However, finding target and developing nanosystems capable selectively delivering siRNAs for disease remains challenge. In this study, lncRNA TMEM44-AS1 that related 5-FU...
Abstract Sunitinib resistance remains a serious challenge to the treatment of advanced and metastatic renal cell carcinoma (RCC), yet mechanisms underlying this are not fully understood. Here, we report that long noncoding RNA IGFL2-AS1 is driver therapy in RCC. was highly upregulated sunitinib-resistant RCC cells associated with poor prognosis patients clear (ccRCC) who received sunitinib therapy. enhanced TP53INP2 expression by competitively binding hnRNPC, multifunctional RNA-binding...
Abstract High lymphocyte infiltration and immunosuppression characterize the tumor microenvironment (TME) in renal cell carcinoma (RCC). There is an urgent need to elucidate how cells escape immune attack develop novel therapeutic targets enhance efficacy of checkpoint blockade (ICB) RCC. Overactivated IFN‐ γ ‐induced JAK/STAT signaling involves such TME, but underlying mechanisms remain elusive. Here, EH domain‐binding protein 1‐like 1 (EHBP1L1) identified as a crucial mediator...
Abstract Metastasis is the main cause of mortality in renal cell carcinoma (RCC). Circular RNAs (circRNAs) involvement RCC metastasis has been described, although underlying mechanisms remain unknown. We evaluated recurring lung-metastasis cases using patient-derived xenograft models and isolated a highly metastatic clone. CircSPIRE1 was identified as metastasis-inhibiting circRNA clinical cohort models. Mechanistically, circSPIRE1 suppressed mesenchymal state through regulating ELAV like...
Abstract Background Colorectal cancer (CRC) is one of the most common malignant tumors digestive system, ranking third for morbidity and mortality worldwide. At present, no effective control method available this type. In tumor cells, especially iron metabolization, necessary its growth proliferation. High levels are an important feature to maintain growth; however, overall mechanism remains unclear. Methods We used western blotting, immunohistochemistry (IHC) real-time quantitative PCR...
Abstract Cervical cancer (CC) is the most common gynecologic malignancy, which seriously threatens health of women. Lipid metabolism necessary for tumor proliferation and metastasis. However, molecular mechanism relationship between CC lipid remains poorly defined. We revealed expression IGF2BP3 in exceeded adjacent tissues, was positively associated with stage using human tissue microarrays. The Cell Counting Kit-8, colony formation assay, 5-ethynyl-2′-deoxyuridine transwell assays,...
Abstract Background The development of chemoresistance and metastasis are the leading causes death for gastric cancer (GC) patients, however, molecular mechanisms involved remain unclear. Dysregulation miRNAs is associated with a variety disease, including GC. Recently, microarray profiling analysis revealed that miR-939 was dysregulated in human GC samples, but role has not been intensively investigated. Methods In present study, we firstly examined expression pattern two independent...
Cisplatin represents one of the first‐line drugs used for non‐small‐cell lung cancer treatment. However, considerable side effects and emergence drug resistance are becoming critical limitations to its application. Combinatorial strategies may be able extend use cisplatin. Both Tanshinone IIA cisplatin inhibit cell growth in a time‐ dose‐dependent manner. When was combined with at ratio 20:1, they were observed exert synergistic inhibitory effect on cells. The combination treatment shown...
Cisplatin (DDP) is the first-line chemotherapeutic agent against lung cancer. However, therapeutic effect of DDP loses over time due to acquired drug resistance in non-small cell cancer (NSCLC) cells. In recent years, role traditional Chinese medicine (TCM) cordycepin (Cor) treatment has been attracting attention. effects Cor on NSCLC are unclear. present study, we aimed investigate combination with proliferation and apoptosis explore possible underlying mechanisms. The were analyzed...
Rab25, an epithelial-specific member of the Rab family small guanosine triphosphatases, is associated with several human cancers. The goal this study was to determine its function in bladder cancer (BC). We examined Rab25 expression pattern two different cohorts BC patients treated radical cystectomy by quantitative PCR, western blotting and immunohistochemical staining. A series vitro vivo assays were performed elucidate underlying mechanisms. significantly elevated at both messenger RNA...
Shortening of the 3' untranslated regions (3'UTR) mRNA is an important mechanism for oncogene activation. However, 3'UTR alteration events, their pathologic functions, and underlying mechanisms in human urothelial carcinoma bladder (UCB) are not clear. Here, we combine RNA sequencing, bioinformatics, clinical studies two independent cohorts patients with UCB to identify a novel RAC1 shorter isoform that frequently expressed critical tumorigenesis acquisition poor prognostic phenotype...
We previously reported the oncogenic role of paired-like homeodomain 2 (PITX2) in esophageal squamous cell carcinoma (ESCC). In this study, we aimed to identify miRNA regulators PITX2 and mechanism underlying pathogenesis ESCC.Using profiling bioinformatics analyses, identified miR-644a as a negative mediator ESCC. A series vivo vitro assays were performed confirm effect on PITX2-mediated ESCC malignancy.ESCC cells tissues expressed less than normal epithelial controls. patient samples,...
Abstract Clear cell renal carcinoma (ccRCC), the most common subtype of carcinoma, can easily invade local tissues and metastasize, is resistant to currently available treatments. Recent studies profiling microRNA expression in ccRCC have suggested miR-30a-5p may be deregulated these cancer cells. To determine its role mechanism action ccRCC, miR-30-5p levels were quantified functions analyzed using vitro vivo experiments bioinformatics. A decrease was frequently noted cells tissues....