A5000409900- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Head and Neck Cancer Studies
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- GDF15 and Related Biomarkers
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Gut microbiota and health
- Immunotherapy and Immune Responses
- Galectins and Cancer Biology
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Molecular Biology Techniques and Applications
- Clostridium difficile and Clostridium perfringens research
- Phagocytosis and Immune Regulation
- Synthesis and Reactivity of Heterocycles
- DNA Repair Mechanisms
- Pomegranate: compositions and health benefits
Shandong Provincial QianFoShan Hospital
2025
Shandong First Medical University
2025
Sun Yat-sen University
2018-2024
Sun Yat-sen University Cancer Center
2018-2024
University of Electronic Science and Technology of China
2022-2024
Sichuan Cancer Hospital
2022-2024
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2023-2024
Army Medical University
2024
Southwest Hospital
2024
New Technology (Israel)
2023
Abstract Background Metastasis causes the vast majority of colorectal carcinoma (CRC)-related deaths. However, little is known about specific traits and underlying mechanisms metastasis-initiating cells in primary CRC. And whether or not circular RNAs (circRNAs) take part this particular event remain adequately stated yet. Methods A screening method based on Transwell assay was first applied to build CRC subgroups with different metastatic potential. High throughput RNA sequencing used find...
Abstract Neoadjuvant chemoimmunotherapy (NACI) has shown promise in the treatment of resectable esophageal squamous cell carcinoma (ESCC). The microbiomes patients can impact therapy response, and previous studies have demonstrated that intestinal microbiota influences cancer immunotherapy by activating gut immunity. Here, we investigated effects intratumoral on response with ESCC to NACI. Intratumoral signatures β-diversity were disparate predicted efficiency enrichment Streptococcus...
The adenomatous polyposis coli (APC) gene plays a pivotal role in the pathogenesis of colorectal carcinoma (CRC) but remains challenge for drug development. Long noncoding RNAs (lncRNAs) are invaluable identifying cancer pathologies and providing therapeutic options patients with cancer. Here, we identified lncRNA (lncRNA-APC1) activated by APC through microarray screening examined its expression large cohort CRC tissues. A decrease lncRNA-APC1 was positively associated lymph node and/or...
Deficiency of DNA repair pathways drives the development colorectal cancer. However, role base excision (BER) pathway in cancer initiation remains unclear. This study shows that Nei-like glycosylase 1 (NEIL1) is highly expressed (CRC) tissues and associated with poorer clinical outcomes. Knocking out neil1 mice markedly suppresses tumorigenesis enhances infiltration CD8+ T cells intestinal tumors. Furthermore, NEIL1 directly forms a complex SATB2/c-Myc to enhance transcription COL17A1...
Hepatocellular carcinoma (HCC) acquires an immunosuppressive microenvironment, leading to unbeneficial therapeutic outcomes. Hyaluronan-mediated motility receptor (HMMR) plays a crucial role in tumor progression. Here, we found that aberrant expression of HMMR could be predictive biomarker for the immune suppressive microenvironment HCC, but mechanism remains unclear. We established −/− liver cancer mouse model elucidate HMMR-mediated dysregulated “don't eat me” signal. knockout inhibited...
Through facilitating DNA homologous recombination repair, PPIP5K2 has been proven to be essential for improving colorectal cancer survival in our previous research. However, its function the tumorigenesis of NSCLC, most common and primary cause cancer-related death globally, is still unknown. Here, we initially discovered that had significant effects on proliferation NSCLC cells through loss- gain-of-function assays vitro vivo. Moreover, capable regulating metastasis an EMT-dependent manner....
DNA high methylation is one of driving force for colorectal carcinoma (CRC) pathogenesis. Transcription factors (TFs) can determine cell fate and play fundamental roles in multistep process tumorigenesis. Dysregulation TFs should be vital the progression CRC. Here, we demonstrated that TBX20, a T-box TF family protein, was downregulated with hypermethylation promoter early-stage CRC tissues correlated poor prognosis patients. Moreover, identified PDZRN3 as E3 ubiquitin ligase TBX20 which...
Abstract Deposition of extracellular matrix (ECM) in the liver is an important feature cirrhosis. Recovery from cirrhosis physiologically challenging, partially due to ECM scar tissue showing resistance cell‐mediated degradation by secreted metalloproteinases (MMPs). Here, a ECM‐degradation screening system (CEDSS) vitro constructed for high‐throughput searching cells with tremendous ability. ECM‐degrading sinusoidal endothelial (dLSECs) are screened using CEDSS, which exhibit 17 times...
Abstract Urolithin families are gut-microbial metabolites of ellagic acid (EA). Although urolithin A (UA) and B (UB) were reported to have antiproliferative activities in cancer cells, the role related mechanisms C (UC) colorectal (CRC) not yet been clarified. In this study, we assess antitumor UC vitro vivo further explore underlying CRC cell lines. We found that inhibited proliferation migration induced apoptosis, arrested cycle at G2/M phase vitro, tumor growth a subcutaneous...
<div>Abstract<p>Neoadjuvant chemoimmunotherapy (NACI) has shown promise in the treatment of resectable esophageal squamous cell carcinoma (ESCC). The microbiomes patients can impact therapy response, and previous studies have demonstrated that intestinal microbiota influences cancer immunotherapy by activating gut immunity. Here, we investigated effects intratumoral on response ESCC to NACI. Intra-tumoral signatures β-diversity were disparate predicted efficiency enrichment...
<p>Table S2 shows clinical characteristics of patients with esophageal squamous cell carcinoma (ESCC) who underwent NACI1 treatment.</p>
<p>Supplementary methods</p>
<p>Supplementary figure legend</p>
<p>Figure S4 shows intra-tumoral bacteria identified in patients with ESCC.</p>
<p>Table S5 shows sequences of the primers used for qRT-PCR.</p>
<p>Table S4 shows reagents and antibodies.</p>
<p>Table S2 shows clinical characteristics of patients with esophageal squamous cell carcinoma (ESCC) who underwent NACI1 treatment.</p>
<p>Table S3 shows clinical characteristics of feces providers for fecal microbiota transplantation.</p>
<p>Table S1 shows clinical characteristics of esophageal squamous cell carcinoma (ESCC) patients who underwent upfront surgery.</p>