A5054881045- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Head and Neck Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Glioma Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Ferroptosis and cancer prognosis
- Clostridium difficile and Clostridium perfringens research
- Immune cells in cancer
- Gut microbiota and health
- Lung Cancer Research Studies
- Plant Pathogens and Fungal Diseases
- Cancer Cells and Metastasis
- High-Temperature Coating Behaviors
- High-Energy Particle Collisions Research
- Essential Oils and Antimicrobial Activity
- Technology Adoption and User Behaviour
- Metal and Thin Film Mechanics
- Medical Imaging Techniques and Applications
- RNA regulation and disease
- Digital Marketing and Social Media
- Nutritional Studies and Diet
Nanjing Drum Tower Hospital
2024
Capital University of Physical Education and Sports
2024
University of Science and Technology of China
2024
Jiangnan University
2024
University of Electronic Science and Technology of China
2022-2023
Sichuan Cancer Hospital
2022-2023
National Engineering Research Center of Electromagnetic Radiation Control Materials
2017
American Political Science Association
1998
Abstract Neoadjuvant chemoimmunotherapy (NACI) has shown promise in the treatment of resectable esophageal squamous cell carcinoma (ESCC). The microbiomes patients can impact therapy response, and previous studies have demonstrated that intestinal microbiota influences cancer immunotherapy by activating gut immunity. Here, we investigated effects intratumoral on response with ESCC to NACI. Intratumoral signatures β-diversity were disparate predicted efficiency enrichment Streptococcus...
Physical exercise is known to reduce anxiety, but the underlying brain mechanisms remain unclear. Here, we explore a hypothalamo-cerebello-amygdalar circuit that may mediate motor-dependent alleviation of anxiety. This three-neuron loop, in which cerebellar dentate nucleus takes center stage, bridges motor system with emotional system. Subjecting animals constant rotarod engages glutamatergic neurons drive PKCδ+ amygdalar elicit an anxiolytic effect. Moreover, challenging on accelerated...
Abstract The interior design suffers from inefficiency and a lack of aesthetic appeal. With the development artificial intelligence diffusion models, using text descriptions to generate aesthetically pleasing designs has emerged as new approach address these issues. In this study, we propose novel method based on model, which can quickly visually appealing input while allowing for specification decorative styles spatial functions. proposed in study creates creative drawings by computer...
The molecular mechanism by which inborn errors of the human RNA lariat-debranching enzyme 1 (DBR1) underlie brainstem viral encephalitis is unknown. We show here that accumulation lariats in DBR1-deficient cells interferes with stress granule (SG) assembly, promoting proteasome degradation at least G3BP1 and G3BP2, two key components SGs. In turn, impaired assembly SGs, normally recruit PKR, impairs PKR activation activity against viruses, including HSV-1. Remarkably, genetic ablation...
Background: Anlotinib is a multi-target anti-angiogenic agent. The retrospective study was conducted to evaluate the safety and effectiveness of anlotinib as monotherapy or combination therapy for treatment recurrent high-grade gliomas. Methods: In this study, patients with glioma (according 2021 World Health Organization classification levels III-IV) at Sichuan Cancer Hospital from June 2019 2022 were included. divided into an anlotinib-monotherapy group anlotinib-combination group,...
This study investigates user experience (UX) sharing behaviors in the context of smartphone interface (UI) design, emphasizing their significance for UI enhancement and effective marketing strategies. Grounded Stimulus–Organism–Response (SOR) framework, we examine how design perception attributes—perceived usability, novelty, enjoyment, brand image—influence UX sharing, with a spotlight on mediating role individual motivation. A quantitative analysis (N = 472), Structural Equation Modeling...
<div>Abstract<p>Neoadjuvant chemoimmunotherapy (NACI) has shown promise in the treatment of resectable esophageal squamous cell carcinoma (ESCC). The microbiomes patients can impact therapy response, and previous studies have demonstrated that intestinal microbiota influences cancer immunotherapy by activating gut immunity. Here, we investigated effects intratumoral on response ESCC to NACI. Intra-tumoral signatures β-diversity were disparate predicted efficiency enrichment...
<p>Table S2 shows clinical characteristics of patients with esophageal squamous cell carcinoma (ESCC) who underwent NACI1 treatment.</p>
<p>Supplementary methods</p>
<p>Supplementary figure legend</p>
<p>Figure S4 shows intra-tumoral bacteria identified in patients with ESCC.</p>
<p>Table S5 shows sequences of the primers used for qRT-PCR.</p>
<p>Table S4 shows reagents and antibodies.</p>
<p>Table S2 shows clinical characteristics of patients with esophageal squamous cell carcinoma (ESCC) who underwent NACI1 treatment.</p>
<p>Table S3 shows clinical characteristics of feces providers for fecal microbiota transplantation.</p>
<p>Table S1 shows clinical characteristics of esophageal squamous cell carcinoma (ESCC) patients who underwent upfront surgery.</p>
<p>Figure S6 shows immune cell clusters and signatures revealed by single-cell RNA sequencing in patients with ESCC.</p>
<p>Table S5 shows sequences of the primers used for qRT-PCR.</p>
<p>Table S4 shows reagents and antibodies.</p>
<p>Figure S7 shows fecal microbial transplantation (FMT) influenced the immune microenvironment of subcutaneous xenograft tumor tissues.</p>
<p>Supplementary figure legend</p>
<p>Figure S6 shows immune cell clusters and signatures revealed by single-cell RNA sequencing in patients with ESCC.</p>
<p>Figure S4 shows intra-tumoral bacteria identified in patients with ESCC.</p>
<p>Figure S5 shows intra-tumoral Microbiota associated with activated immune cell infiltration.</p>