Yan Guo

ORCID: 0009-0008-4547-9381
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About
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Research Areas
  • Microscopic Colitis
  • Clostridium difficile and Clostridium perfringens research
  • Healthcare Policy and Management
  • Digital Platforms and Economics
  • Radiomics and Machine Learning in Medical Imaging
  • Magnesium Alloys: Properties and Applications
  • Hydrogen Storage and Materials
  • Gut microbiota and health
  • Viral gastroenteritis research and epidemiology
  • Advancements in Battery Materials
  • Supercapacitor Materials and Fabrication
  • Microtubule and mitosis dynamics
  • Enhanced Oil Recovery Techniques
  • Signaling Pathways in Disease
  • Smart Parking Systems Research
  • Biochemical and Structural Characterization
  • Plant Stress Responses and Tolerance
  • Thermodynamic and Structural Properties of Metals and Alloys
  • Intracerebral and Subarachnoid Hemorrhage Research
  • Advanced X-ray and CT Imaging
  • Infrared Target Detection Methodologies
  • Vehicular Ad Hoc Networks (VANETs)
  • Environmental Toxicology and Ecotoxicology
  • Aerogels and thermal insulation
  • Advanced Fiber Optic Sensors

Xi'an Polytechnic University
2024

Jilin Medical University
2024

Tangshan Normal University
2024

University of Science and Technology of China
2024

Jilin University
2024

Nanjing University
2024

Xi'an Jiaotong University
2024

Zhengzhou Business University
2024

Zhengzhou University
2024

Ningbo University
2024

Abstract Low temperature is a major factor limiting rice productivity and geographical distribution. Improved cold tolerance expanded cultivation to high-altitude or high-latitude regions would help meet growing demand. Here we explored QTL for cloned the gene, CTB4a (cold at booting stage), encoding conserved leucine-rich repeat receptor-like kinase. We show that different alleles confer distinct levels of selection variation in promoter region has occurred on basis environmental...

10.1038/ncomms14788 article EN cc-by Nature Communications 2017-03-23

Clostridioides difficile infection (CDI) is the leading cause of hospital-acquired diarrhea that seriously threatens public health. The disruption normal gut microbiota by use broad-spectrum antimicrobial agents enables C. to proliferate in colon. emergence and prevalence hypervirulent strains result increased morbidity, mortality, high recurrence rates CDI, thus creating a pressing need for novel therapeutics. multi-domain toxins TcdA TcdB are primary determinants CDI pathogenesis,...

10.7554/elife.101757.2 preprint EN 2025-04-08

Abstract Hyperlipidemia and hypertension might play a role in cardiac fibrosis, which heterogeneous population of fibroblasts seems important. However, it is unknown whether CD34 + progenitor cells are involved the pathogenesis heart fibrosis. This study aimed to explore mechanism cell differentiation fibrosis during hyperlipidemia. Through analysis transcriptomes from 50,870 single extracted mouse hearts 76,851 human hearts, we have effectively demonstrated evolving cellular landscape...

10.1038/s12276-024-01309-9 article EN cc-by Experimental & Molecular Medicine 2024-08-29

The molecular mechanism by which inborn errors of the human RNA lariat-debranching enzyme 1 (DBR1) underlie brainstem viral encephalitis is unknown. We show here that accumulation lariats in DBR1-deficient cells interferes with stress granule (SG) assembly, promoting proteasome degradation at least G3BP1 and G3BP2, two key components SGs. In turn, impaired assembly SGs, normally recruit PKR, impairs PKR activation activity against viruses, including HSV-1. Remarkably, genetic ablation...

10.1084/jem.20240010 article EN The Journal of Experimental Medicine 2024-12-05

The closed-loop material and energy cycles of islands increase the susceptibility their internal ecosystem components to heavy metal accumulation transfer. However, limited research on island scale hinders our understanding environmental geochemistry in this unique environment. This study focused assessing a tropical island’s ecological risk by investigating contamination potential sources. results revealed elevated cadmium nickel concentrations 0.44–1.31% soil samples, particularly coastal...

10.3390/agronomy14081777 article EN cc-by Agronomy 2024-08-13

10.1109/ijcnn60899.2024.10651431 article EN 2022 International Joint Conference on Neural Networks (IJCNN) 2024-06-30

10.1016/j.jpcs.2024.112518 article EN Journal of Physics and Chemistry of Solids 2024-12-01

Abstract Food preferences play a pivotal role in dietary choices and body weight regulation, yet the causal relationships complex pathways linking food liking to obesity remain elusive. Here, we employed two-sample Mendelian randomization (MR) analysis pleiotropic explore causalities shared loci between 187 ( N =161,625) five obesity-related phenotypes =100,716 322,154). MR revealed association two food-liking increased mass index (BMI), specifically, onion (β, 0.286; 95% CI, 0.185 0.387; P...

10.1101/2024.06.13.24308909 preprint EN cc-by-nc-nd medRxiv (Cold Spring Harbor Laboratory) 2024-06-14

Heterogeneous phase combined flooding (HPCF) has been a promising technology used for enhancing oil recovery in heterogeneous mature reservoirs. However, the injectivity and propagation behavior of preformed particle gel (PPG) low–medium-permeability reservoir porous media is crucial HPCF treatment reservoir. Thus, were systematically studied by conducting series sand pack experiments. The matching factor (δ) was defined as ratio average size PPG particles to mean pore throats pressure...

10.3390/gels10070475 article EN cc-by Gels 2024-07-18

The beveling process is an important in the manufacturing of resonators, which has a significant impact on frequency stability resonators. Without understanding characteristics resonator after beveling, it impossible to accurately design beveled Thus, order investigate vibration AT-cut we investigated high-frequency this work by using subregional geometric fitting method (SGFM) based Mindlin's plate theory. Quartz crystal plates with nonuniform thicknesses are partitioned into three regions...

10.1038/s41598-024-67846-5 article EN cc-by-nc-nd Scientific Reports 2024-07-25

Existing research suggests that government regulation and firm self-discipline are the primary factors in achieving effective product quality regulation. Building on previous research, this study examines role of employees as participants We construct a tripartite evolutionary game model involving employees, government, firms to analyze impact employee whistleblowing The results indicate effectiveness monitoring enterprises governments is influenced by accountability, severity administrative...

10.1080/1540496x.2024.2380074 article EN Emerging Markets Finance and Trade 2024-07-31

Hepatectomy is an important therapeutic method for hepatocellular carcinoma (HCC). The overall survival rate of patients with early recurrence often lower than that without recurrence. Therefore, this worked aimed at investigating the value texture analysis based on R2* map predicting HCC after hepatectomy. Eleven optimal features were obtained to predict HCC. This research suggested had certain predictive hepatectomy, which was valuable noninvasively, preoperatively and accurately...

10.58530/2023/2245 article EN Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition 2024-08-14

Composite medical dressings are made by combining different materials to achieve functions that cannot be realized a single material, making it an important research direction for dressings. This study utilized the unique grooved structure of lotus stem fibers, and functionality provided preparation processes each layer material prepare dressing can super-strong liquid absorption storage effects. The prepared were characterized analyzed through performance tests, Fourier transform infrared...

10.1177/00405175241251842 article EN Textile Research Journal 2024-08-14

Abstract The Toll‐like receptor 9 (TLR9) stimulator, CpG oligodeoxynucleotide, has emerged as a potent enhancer of protein subunit vaccines. Incorporating the antigen directly with adjuvant presents novel strategy to significantly reduce required dosage compared traditional methods that use separate components. In contrast existing chemical conjugation methods, this study introduces an enzymatic approach for antigen‐adjuvant coupling using recombinant endonuclease DCV fused SpyTag. This...

10.1002/smtd.202401116 article EN Small Methods 2024-08-23

Abstract Clostridioides difficile infection (CDI) is the leading cause of hospital- acquired diarrhea that seriously threatens public health. The disruption normal gut microbiota by use broad-spectrum antimicrobial agents enables C. to proliferate in colon. emergence and prevalence hypervirulent strains result increased morbidity, mortality, recurrence rates CDI, thus creating a pressing need for novel therapeutics. multi-domain toxins TcdA TcdB are primary determinants CDI pathogenesis,...

10.1101/2024.08.19.608683 preprint EN cc-by bioRxiv (Cold Spring Harbor Laboratory) 2024-08-20
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