A5013564157- Viral gastroenteritis research and epidemiology
- RNA regulation and disease
- Animal Virus Infections Studies
- Drug Transport and Resistance Mechanisms
- RNA modifications and cancer
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Viral Infections and Immunology Research
- RNA Research and Splicing
University of Science and Technology of China
2024
Shandong Agricultural University
2023
Shandong Center for Disease Control and Prevention
2023
The molecular mechanism by which inborn errors of the human RNA lariat-debranching enzyme 1 (DBR1) underlie brainstem viral encephalitis is unknown. We show here that accumulation lariats in DBR1-deficient cells interferes with stress granule (SG) assembly, promoting proteasome degradation at least G3BP1 and G3BP2, two key components SGs. In turn, impaired assembly SGs, normally recruit PKR, impairs PKR activation activity against viruses, including HSV-1. Remarkably, genetic ablation...
Novel duck orthoreovirus can infect various hosts, mainly causing spleen necrosis and hemorrhagic necrotizing hepatitis, leading to immunosuppression growth impairment. Infectious diseases characterized by swollen hock joints, movement disorders, impaired growths have recently occurred in significant breeding areas China. Infected ducks from Shandong Province were selected, N-DRV-LY20 was isolated the joints. Next-generation sequencing (NGS) of homology analysis showed that all ten fragments...