A5100391312- RNA modifications and cancer
- Glycosylation and Glycoproteins Research
- Heat shock proteins research
- RNA Research and Splicing
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer-related gene regulation
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- DNA Repair Mechanisms
- Ubiquitin and proteasome pathways
- Bioinformatics and Genomic Networks
- Advanced biosensing and bioanalysis techniques
- Epigenetics and DNA Methylation
- Genomics and Phylogenetic Studies
- Cancer, Hypoxia, and Metabolism
- Gut microbiota and health
- Porphyrin Metabolism and Disorders
- Circular RNAs in diseases
- Lipoproteins and Cardiovascular Health
- Genetic diversity and population structure
- Plant tissue culture and regeneration
- Galectins and Cancer Biology
- Metabolomics and Mass Spectrometry Studies
Sun Yat-sen University
2021-2025
Sixth Affiliated Hospital of Sun Yat-sen University
2025
Sun Yat-sen University Cancer Center
2021-2024
Hainan Medical University
2021-2023
Hebei Medical University
2023
Fourth Hospital of Hebei Medical University
2023
Tianjin University of Traditional Chinese Medicine
2023
Hebei University of Chinese Medicine
2023
Nanjing Drum Tower Hospital
2022
State Key Laboratory of Oncology in South China
2021-2022
The aim of this study was to investigate whether supplementation with resveratrol could alleviate intestinal injuries and explore how regulates heat shock protein (HSP)70, HSP90, nuclear factor kappa B (NF-κB) epidermal growth (EGF) expression in the jejunal mucosa black-boned chickens under circular stress. A total 300 chicks 42-d-old were randomly assigned five treatment groups. positive control kept a normal-temperature (NT, 24 ± 2 °C) chamber fed basal diet. other four groups...
Deficiency of DNA repair pathways drives the development colorectal cancer. However, role base excision (BER) pathway in cancer initiation remains unclear. This study shows that Nei-like glycosylase 1 (NEIL1) is highly expressed (CRC) tissues and associated with poorer clinical outcomes. Knocking out neil1 mice markedly suppresses tumorigenesis enhances infiltration CD8+ T cells intestinal tumors. Furthermore, NEIL1 directly forms a complex SATB2/c-Myc to enhance transcription COL17A1...
Abstract Glutathione S -transferase omega 1 (GSTO1) is an atypical GST isoform that overexpressed in several cancers and has been implicated drug resistance. Currently, no small-molecule targeting GSTO1 under clinical development. Here we show silencing of with siRNA significantly impairs cancer cell viability, validating as a potential new target oncology. We report on the development characterization series chloroacetamide-containing potent inhibitors. Co-crystal structures our inhibitors...
Abstract This study investigated the effect of dietary resveratrol supplementation on growth performance, rectal temperature, and serum parameters yellow‐feather broilers under heat stress. A total 480 (28‐day‐old) were randomly allotted to five groups with six replicates. thermoneutral group ( TN ) (24 ± 2°C) received a basal diet another four heat‐stressed (37 2°C for 8 hr/day 24 remaining time) fed or 200, 350, 500 mg/kg 14 consecutive days. The results revealed that improved average...
Introduction The advanced maternal age (AMA) pregnancies escalate rapidly, which are frequently linked to higher risks of adverse outcomes. Advanced placenta exhibited premature aging, presumably resulting in trophoblast dysfunction, inadequate placentation. However, the precise reasons and mechanisms aging AMA remain unclear, posing a significant limitation provide effective guidance for prenatal healthcare clinical settings. Notably, organism shows heightened vulnerability oxidative damage...
Avian influenza virus (H5N1) has caused serious infections in human beings. This the potential to emerge as a pandemic threat humans. Effective vaccines against H5N1 are needed. A recombinant Bombyx mori baculovirus, Bmg64HA, was constructed for expression of HA protein displaying on viral envelope surface. The accounted approximately 3% total proteins silkworm pupae infected with virus. Using series separation and purification methods, pure Bmgp64HA isolated from these bioreactors. Aluminum...
// Si Li 1, * , Hai-Yan Zhang 2, Zhen-Xian Du 3 Chao 1 Ming-Xin An Zhi-Hong Zong Bao-Qin Liu Hua-Qin Wang Department of Biochemistry and Molecular Biology, China Medical University, Shenyang 110001, 2 Geriatrics, the 1st Affiliated Hospital, Endocrinology Metabolism, These authors contributed equally to this work Correspondence to: Wang, email: hqwang@cmu.edu.cn Keywords: Beclin1, EMT, invasion, thyroid cancer Received: May 02, 2016 Accepted: September Published: 23, ABSTRACT Beclin has...
Bcl-2 associated athanogene 3 (BAG3) is highly expressed in pancreatic ductal adenocarcinoma (PDAC), and its high expression appears to be a poor prognostic factor for patients with PDAC. In this study, we show that BAG3 knockdown significantly decreases migration invasion of PDACs via reduction interleukine-8 (IL-8) production. regulates IL-8 at the posttranscriptional levels interplay between recruitment RNA-binding protein HuR miR-4312. binds cis-elements located 3'-untranslational region...
The intestinal microbiome plays a crucial role in promoting health, and perturbations to its constitution may result chronic inflammation lead colorectal cancer (CRC). α -Ketoglutarate is an important intermediary the NF- κ B-mediated inflammatory pathway that maintains homeostasis prevents initiation of inflammation, known precursor carcinoma development. objective this study was assess potential protective effects -ketoglutarate intervention against CRC development, which arise due...
Abstract BAG3 is an evolutionarily conserved co-chaperone expressed at high levels and has a prosurvival role in many tumor types. The current study reported that was induced under specific floating culture conditions enrich breast cancer stem cell (BCSC)-like cells spheres. Ectopic overexpression increased CD44 + /CD24 − CSC subpopulations, first-generation second-generation mammosphere formation, indicating promotes self-renewal maintenance cancer. We further demonstrated mechanically,...
Esophageal squamous cell carcinoma (ESCC) is a leading cause of cancer death worldwide. MicroRNAs (MiRNAs) have been reported to regulate functions through exosomes. Through the Gene Expression Omnibus (GEO) database, miR-620 was selected as serum miRNA highly expressed in ESCC, but its detailed role ESCC has not explored. Tumor-secreted miRNAs promote metastasis reprogramming aerobic glycolysis lung fibroblasts. Therefore, we intended verify whether exosomal secreted cells may...
Dengue infection is one of the most prevalent arthropod-borne viral diseases, which can result in severe complications. Identification genes and long non-coding RNAs (lncRNAs) involved dengue would help deciphering potential mechanisms responsible for disease progression. We comprehensively analyzed dynamic transcriptome during progression identified critical lncRNAs with expression perturbations. Our findings revealed that (i.e., CCR10 GNG7) CTBP1-AS MAFG-AS1) were potentially regulated by...
Abstract Mucosal-associated invariant T (MAIT) cells are an cell subset, which have been reported to play antimicrobial role in infectious diseases. However, little is known about it malignant diseases and tumors, especially gastric cancer (GC). So this study, we aim examine the frequency, phenotype, partial functional capacity clinical relevance of from GC patients’ peripheral blood by flow cytometry. It was shown that frequency MAIT negatively correlated with their increasing age healthy...
The protein-protein interactions (PPIs) between human and viruses play important roles in viral infection host immune responses. Rapid accumulation of experimentally validated human-virus PPIs provides an unprecedented opportunity to investigate the regulatory pattern infection. However, we are still lack knowledge about patterns interactions. We collected 27,293 PPIs, covering 8 virus families, 140 proteins 6059 proteins. Functional enrichment analysis revealed that interacting were likely...
Resolvin D1 (RvD1) is a pro-resolving lipid mediator of inflammation, endogenously synthesized from omega-3 docosahexaenoic acid. The purpose this study was to investigate the effect RvD1 on bone regeneration using rat calvarial defect model. Collagen 3D nanopore scaffold (COL) and Pluronic F127 hydrogel (F127) incorporated with (RvD1-COL-F127 group) or COL (COL-F127 were implanted in symmetrical defects. After implantation, administrated subcutaneously every 7 days for 4 weeks. rats...
DNA high methylation is one of driving force for colorectal carcinoma (CRC) pathogenesis. Transcription factors (TFs) can determine cell fate and play fundamental roles in multistep process tumorigenesis. Dysregulation TFs should be vital the progression CRC. Here, we demonstrated that TBX20, a T-box TF family protein, was downregulated with hypermethylation promoter early-stage CRC tissues correlated poor prognosis patients. Moreover, identified PDZRN3 as E3 ubiquitin ligase TBX20 which...
Abstract Background MicroRNAs (miRNAs) of plasma-derived small extracellular vesicles (sEVs) have been proven to be associated with metastasis in several types cancer. This study aimed detect miRNAs sEVs as potential biomarkers for metastatic non-small cell lung cancer (NSCLC). Methods We assessed the miRNA profiles from healthy individuals control group (CT group), NSCLC patients without distant organ NM-NSCLC and M-NSCLC group. Next-generation sequencing (NGS) was performed on samples,...