A5018515481- Oral microbiology and periodontitis research
- Immune Response and Inflammation
- Oral and gingival health research
- Periodontal Regeneration and Treatments
- Oral Health Pathology and Treatment
- Orthodontics and Dentofacial Orthopedics
- Inflammatory mediators and NSAID effects
- Fatty Acid Research and Health
- Advanced Glycation End Products research
- Dental Implant Techniques and Outcomes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Salivary Gland Disorders and Functions
- Oral and Maxillofacial Pathology
- S100 Proteins and Annexins
- Dental Radiography and Imaging
- Bone and Dental Protein Studies
- dental development and anomalies
- Laser Applications in Dentistry and Medicine
- Streptococcal Infections and Treatments
- Proteoglycans and glycosaminoglycans research
- Diabetes and associated disorders
- HIV/AIDS oral health manifestations
- Hedgehog Signaling Pathway Studies
- Protease and Inhibitor Mechanisms
- Endodontics and Root Canal Treatments
Harvard University
2015-2025
University of Minnesota
2025
Boston University
2008-2024
Forsyth Technical Community College
2014-2024
University of Pennsylvania
2024
University of Connecticut
2023
University of Michigan
2023
University of Maryland, College Park
2023
University at Buffalo, State University of New York
2023
Cambridge in America
2018
Background: Platelet‐rich plasma (PRP) promotes regeneration of bone, presumably through the action concentrated growth factors. However, it is not clear how PRP affects inflammatory response. The purpose this study was to analyze factors in and effects on monocyte cytokine release lipoxin A 4 (LXA ) generation. Methods: prepared from healthy donors. Platelet‐derived factor (PDGF)‐AB, PDGF‐BB, transforming factor‐β1, insulin‐like factor‐I, fibroblast factor‐basic (FGF‐b), epidermal (EGF),...
Abstract Resolvin E1 (RvE1) is a potent proresolving mediator of inflammation derived from omega-3 eicosapentaenoic acid that acts locally to stop leukocyte recruitment and promote resolution. RvE1 displays counter-regulatory tissue-protective actions in vitro vivo. Periodontal disease local inflammatory initiated by bacteria characterized neutrophil-mediated tissue injury followed development chronic immune lesion. In this study, we report the treatment established periodontitis using as...
Periodontitis is a well-appreciated example of leukocyte-mediated bone loss and inflammation that has pathogenic features similar to those observed in other inflammatory diseases such as arthritis. Resolvins are new family bioactive products omega-3 fatty acid transformation circuits initiated by aspirin treatment counter proinflammatory signals. Because it now increasingly apparent local plays critical role many diseases, including cardiovascular disease, atherosclerosis, asthma,...
Abstract PGs and leukotrienes (LTs) mediate cardinal signs of inflammation; hence, their enzymes are targets current anti-inflammatory therapies. Products arachidonate 15-lipoxygenases (LO) types I II display both beneficial roles, such as lipoxins (LXs) that stereoselectively signal counterregulation, well potential deleterious actions (i.e., nonspecific phospholipid degradation). In this study, we examined transgenic (TG) rabbits overexpressing 15-LO type response to inflammatory...
Abstract Background A variety of systemic diseases and conditions can affect the course periodontitis or have a negative impact on periodontal attachment apparatus. Gingival recessions are highly prevalent often associated with hypersensitivity, development caries non‐carious cervical lesions exposed root surface impaired esthetics. Occlusal forces result in injury teeth Several developmental acquired prostheses may predispose to periodontium. The aim this working group was review update...
Objective— Epidemiological and recent clinical studies implicate periodontitis as an independent risk factor for cardiovascular disease. Previously, we demonstrated that rabbits with experimental cholesterol diet exhibit more aortic plaque compared alone. We also showed a proresolution mediator, Resolvin E1 (RvE1), reverses the periodontitis. Here, determined whether oral/topical application of RvE1 attenuates atherosclerosis induced by both periodontal inflammation. Approach Results—...
Modifying the balance between resorption and apposition through selectively injuring cortical plate of alveolus has been an approach to speed tooth movement is referred as periodontally accelerated osteogenic orthodontics. The aim this study was investigate alveolar response corticotomy a function time proximity surgical injury in rat model.Maxillary buccal lingual plates were injured 36 healthy adult rats adjacent upper left first molars. Twenty-four animals euthanized at 3, 7, or 11 weeks....
Background: Host modulatory therapy has been proposed as a treatment for periodontal diseases. Omega‐3 (ω‐3) polyunsaturated fatty acids (PUFAs), including docosahexaenoic acid (DHA) and eicosapentaenoic (EPA), were shown to have therapeutic anti‐inflammatory protective actions in inflammatory diseases periodontitis. The goal of this study was test an innovative strategy clinical experiment. Methods: Eighty healthy subjects (40 each group) with advanced chronic periodontitis enrolled...
Inflammation is a complex reaction to injurious agents and includes vascular responses, migration activation of leukocytes. starts with an acute reaction, which evolves into chronic phase if allowed persist unresolved. Acute inflammation rapid onset; relatively short process characterized by fluid exudation emigration leukocytes, primarily neutrophils, whereas extends over longer time associated lymphocyte macrophage infiltration, blood vessel proliferation, fibrosis. terminated when the...
Abstract Periodontitis is a biofilm-induced inflammatory disease characterized by dysbiosis of the commensal periodontal microbiota. It unclear how natural regulation inflammation affects biofilm. Promoters active resolution inflammation, including resolvin E1 (RvE1), effectively treat periodontitis in animal models. The goals this study were 1) to compare tissue gene expression different clinical conditions, 2) determine impact local on composition subgingival bacteria, and 3) understand...
Therapies to reverse tissue damage from osteolytic inflammatory diseases are limited by the inability of current tissue-engineering procedures restore lost hard and soft tissues. There is a critical need for new therapeutics in regeneration. In addition scaffolds, cells, soluble mediators necessary engineering, control endogenous inflammation an absolute requirement success. Although significant progress has been made understanding natural resolution pathways limit uncontrolled disease,...
Numerous strategies have been proposed to decrease the treatment time a patient requires in orthodontic treatment. Recently, number of device-accelerated therapies emerged orthodontics. Photobiomodulation is an emerging area science that has clinical applications human biological processes. The aim this study was determine if photobiomodulation reduces alignment phase treatment.This multicenter trial performed on 90 subjects (73 test and 17 controls), Little's Index Irregularity (LII) used...