A5101645765- Lung Cancer Diagnosis and Treatment
- Renal and related cancers
- Renal cell carcinoma treatment
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Chronic Kidney Disease and Diabetes
- Sharing Economy and Platforms
- Cancer, Hypoxia, and Metabolism
- Advanced MRI Techniques and Applications
- Radiation Dose and Imaging
- Glycosylation and Glycoproteins Research
- Digital Platforms and Economics
- Atomic and Subatomic Physics Research
- Endoplasmic Reticulum Stress and Disease
- Hematopoietic Stem Cell Transplantation
- HER2/EGFR in Cancer Research
- Esophageal Cancer Research and Treatment
- Magnesium in Health and Disease
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Biochemical Analysis and Sensing Techniques
- Tuberous Sclerosis Complex Research
- Heat shock proteins research
- Photochromic and Fluorescence Chemistry
- Melanoma and MAPK Pathways
Central Hospital of Zibo
2020-2025
Guangzhou Medical University
2021-2024
First Affiliated Hospital of Guangzhou Medical University
2024
Henan Cancer Hospital
2007-2024
Zhengzhou University
2016-2024
State Key Laboratory of Respiratory Disease
2021-2024
Shandong University
2020-2021
ORCID
2021
Nanchang University
2020
China Medical University
2010-2019
Hormones and immune imbalance are critical factors in polycystic ovary syndrome (PCOS). The alternation of microenvironment oocytes may play a significant role infertility PCOS patients.This study explores the follicular fluid change inflammatory pathways activation granulosa cells (GCs) women infertility.We enrolled 27 patients 30 controls aged 22 to 38 years who underwent IVF collected their luteinized (LGCs). Meanwhile, granulosa-like tumor cell line (KGN) as cell-model assisted this...
Immune checkpoint inhibitors (ICIs) have revolutionized treatment for advanced lung cancer, yet their cardiotoxicity, particularly immune inhibitor-related myocarditis, poses significant clinical challenges. This study aims to create a predictive model using cardiac biomarkers identify patients prone myocarditis during treatment, thereby enhancing decision-making and patient outcomes. In this retrospective cohort study, 1,838 with locally metastatic cancer abnormal baseline parameters...
We quantitatively analyzed the characteristics of cone-beam computed tomography (CBCT) radiomics in different periods during radiotherapy (RT) and then built a novel nomogram model integrating clinical features dosimetric parameters for predicting radiation pneumonitis (RP) patients with esophageal squamous cell carcinoma (ESCC).At our institute, retrospective study was conducted on 96 ESCC whom we had complete feature parameter data. CBCT images each patient three RT were obtained,...
Seed amplification assays (SAA) enable the of pathological misfolded proteins, including α-synuclein (αSyn), in both tissue homogenates and body fluids Parkinson's disease (PD) patients. SAA involves repeated cycles shaking or sonication coupled with incubation periods. However, this scheme has limitations tracking protein propagation due to fragmentation.
The epithelial–mesenchymal transition (EMT) of tubular epithelial cells to myofibroblast-like plays a substantial role in renal tubulointerstitial fibrosis, which is common pathological character end-stage disease (ESRD). Fibroblast growth factor-2 (FGF-2) triggers EMT and increases Bcl-2-associated athanogene 3 (BAG3) expression neural progenitor neuroblastoma cells. In addition, novel regulation has been ascribed BAG3 recently. These previous reports urged us study the potential...
The p21-activated kinase (PAK) family of serine/threonine kinases plays a pivotal role in various human tumors, as supported by our previous report on the overexpressed PAK isoforms non-small cell lung cancer (NSCLC). To better understand PAKs tumorigenesis, authors examined PAK1 expression patterns and its significance NSCLC. It was demonstrated immunohistochemical staining that increased localized cytoplasm 151 207 cases. High levels correlated with histologic type tumor (squamous...
Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a rare autosomal dominant syndrome caused by germline mutation in the fumarate hydratase (FH) gene that manifests with cutaneous leiomyomas, uterine fibroids, (RCC). Patients HLRCC-associated RCC (HLRCC-RCC) have aggressive clinical courses, but there no standardized therapy for advanced HLRCC-RCC. In this study, we described case of HLRCC 33-year-old female who exhibited novel heterozygous insertion exon 8 FH (c.1126 C > T;...
Humanized anti-CD25 monoclonal antibody treatment of steroid-refractory acute graft-versus-host disease: a Chinese single-center experience in group 64 patients
To assess the relationship between different doses of radiation and lung density changes to determine ability this correlation identify esophageal cancer (EC) patients who develop pneumonitis (RP) occurrence time RP.A planning computed tomography (CT) scan a re-planning CT were retrospectively collected under institutional review board approval for each 103 thoracic segment EC underwent radiotherapy (RT). The isodose curve was established on with an interval 5 Gy, which used as standard...
<title>Abstract</title> Hereditary leiomyomatosis and renal cell cancer (HLRCC) was a rare autosomal dominant syndrome caused by germline mutation in the fumarate hydratase (FH) gene; it manifestsas cutaneous leiomyomas, uterine fibroids, (RCC). Patients with HLRCC-associated RCC (HLRCC-RCC) had aggressive clinical courses, but there no standardized therapy for advanced HLRCC-RCC. In this study, we described an HLRCC 33-year-old female who exhibited novel heterozygous insertion exon 8 of FH...
The STK11 gene mutation is a common genetic alteration in non-small cell lung cancer (NSCLC) and significantly associated with poor responses to current immunotherapy regimens. Despite its prevalence, there currently no established standard for front-line treatment this subtype of NSCLC, underscoring the increasing need personalized therapeutic strategies. In report, we present case patient STK11-mutant NSCLC who was treated first-line cadonilimab (10mg/kg) combination pemetrexed (500mg/m^2)...
Studies confirmed that trastuzumab plus fluorouracil-based chemotherapy improves the survival to more than 1 year in human with epidermal growth factor receptor-2 (HER2)-positive advanced gastric cancer. However, there are still a small proportion of patients who do not benefit from treatment.
Aim: The discrimination of renal cell carcinoma from angiomyolipoma (RAML) is crucial for the effective treatment each. Materials & methods: Serum samples were analyzed by nuclear magnetic resonance spectroscopy-based metabolomics and a number metabolites further quantified HPLC-UV. Results: Clear-cell (ccRCC) was characterized drastic disruptions in energy, amino acids, creatinine uric acid metabolic pathways. A logistic model differential diagnosis RAML ccRCC established using combination...