A5073223555- Cervical Cancer and HPV Research
- Immune Response and Inflammation
- Ovarian function and disorders
- Cancer-related molecular mechanisms research
- Reproductive System and Pregnancy
- Reproductive Biology and Fertility
- interferon and immune responses
- Hepatitis B Virus Studies
- Hemoglobinopathies and Related Disorders
- Pregnancy and preeclampsia studies
- Endometriosis Research and Treatment
- Reproductive Physiology in Livestock
- Viral Infections and Vectors
- MicroRNA in disease regulation
- RNA regulation and disease
- Pregnancy-related medical research
- Lipid metabolism and disorders
- Soil Carbon and Nitrogen Dynamics
- RNA modifications and cancer
- Reproductive tract infections research
- Iron Metabolism and Disorders
- Circular RNAs in diseases
- Kruppel-like factors research
- Immunotherapy and Immune Responses
- NF-κB Signaling Pathways
Institute of Environment and Sustainable Development in Agriculture
2025
Jinan University
2014-2024
Guangdong Province Women and Children Hospital
2018-2024
Florida Fertility Institute
2023
Guangzhou Medical University
2019-2022
Weatherford College
2020
Jinan University
2018
Guangdong Provincial Family Planning Hospital
2009-2016
National Health and Family Planning Commission
2016
Hormones and immune imbalance are critical factors in polycystic ovary syndrome (PCOS). The alternation of microenvironment oocytes may play a significant role infertility PCOS patients.This study explores the follicular fluid change inflammatory pathways activation granulosa cells (GCs) women infertility.We enrolled 27 patients 30 controls aged 22 to 38 years who underwent IVF collected their luteinized (LGCs). Meanwhile, granulosa-like tumor cell line (KGN) as cell-model assisted this...
Mounting evidence has revealed that impaired spiral artery remodeling, placental dysfunction, and inadequate trophoblast invasion are closely correlated with the etiology pathogenesis of pre-eclampsia (PE). Moreover, defective may trigger poor maternal-fetal circulation hypoxia, leading to PE. However, detailed molecular pathology PE remains unclear. Although circRNAs, as a new type stable abundant endogenous noncoding RNA, have been proven be essential various diseases, their role in...
Abstract Background Polycystic ovarian syndrome (PCOS) is a common endocrine and metabolic disease in women. Hyperandrogenaemia (HA) insulin resistance (IR) are the basic pathophysiological characteristics of PCOS. The aetiology PCOS has not been fully identified generally believed to be related combined effects genetic, metabolic, internal, external factors. Current studies have screened for susceptibility genes large population. Here, we aimed study effect TGF-β1 methylation on clinical...
The prevalence of human papillomavirus (HPV) infection and the distribution different HPV genotypes vary greatly within geographical ethnic populations, especially in Asia. data based on regional population are extremely important for researchers to develop new efficient screening assays estimate effect vaccines preventing from cervical cancer.A total 78,355 women Guangdong Province, China, whose ages were 18 75 years enrolled this study. All epidemiological obtained by face-to-face...
Polycystic ovary syndrome (PCOS) represents a serious reproductive and endocrine condition is associated with high incidence rates. H19 compelling long noncoding RNA (lncRNA) which carries out range of biological functions. However, prior to this study, little was known as whether there an association between lncRNA PCOS. In the current we used quantitative real-time polymerase chain reaction (qRT-PCR) determine expression levels in peripheral blood leukocytes from patients PCOS compared...
It is important to understand the specific HPV genotype distribution in screen-detected lesions. Genotype helpful for separating HPV-positive women at greater risk of cancer from those who can regress spontaneously and preventing cervical early stage. The aim this study was investigate high-risk among cytology abnormality Pearl River Delta Region, Southern China 5585 HPV-infected were screened 77069 Region. Information obtained 3226 subjects through questionnaires personal interviews....
Abstract The diagnosis and treatment of unexplained recurrent spontaneous abortion (URSA) is an important hot topic in the field obstetrics gynecology. During our clinical investigation (observation), we have found that URSA patients usually experience vaginitis or vaginal dysbacteriosis during periods non-pregnancy, pregnancy, post-abortion. However, there no research on dysbacteriosis's influence URSA. Using women with normal induced as a control group, using 16S rRNA sequencing, which...
Identifying the mechanisms underlying unexplained recurrent spontaneous abortion (URSA) can help develop effective treatments. This study provides novel insights into biological characteristics and related pathways of differentially expressed genes (DEGs) in URSA. Nineteen patients with URSA three healthy fertile women regular menstruation (control group) were recruited. RNA was extracted from two groups to determine differential expression immunoregulatory gene sequences. Gene ontology (GO)...
Background Cognitive decline can develop into mild cognitive impairment, a high-risk factor in the progression of Alzheimer's disease. The antioxidant micronutrient selenium may have some effect on preventing decline, but association between whole blood concentration and function remains controversial.Aim To investigate score elderly Americans.Subjects methods Data was obtained from national health nutrition survey 2011 2014. A general linear model used to adjust for possible risk factors...
The etiology of polycystic ovary syndrome (PCOS) is complex and the pathogenesis not fully understood. Some studies have shown that dysregulation ovarian granulosa cells may be related to abnormal follicles excessive androgen in women with PCOS. Our team has also confirmed high expression status H19 PCOS patients early stage. However, relationship between miR-19b development still unknown. Therefore, we used bioinformatics predict binding sites human miR-19b, CTGF genes. After silencing...
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common gynecologic endocrinopathy, characterized by menstrual disorders, ovulation polycystic ovary, hyperandrogen and insulin resistance. At present, the etiology exact pathogenesis of PCOS are still unclear. Anti-Müllerian hormone local regulator secreted ovarian granulosa cells, participates in regulating occurrence development PCOS. Insulin resistance another important pathophysiological feature Although expression anti-müllerian receptor...
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are widely used in consumer products. However, the role of PFAS infertility is still poorly understood. A total 788 women from 2013-2016 nationally representative NHANES were included to explore association between exposure self-reported infertility. Six PFAS, including PFDE, PFNA, PFHxS, n-PFOA, n-PFOS, Sm-PFOS, detected by online SPE-HPLC-TIS-MS/MS. We generalized linear regression model (GLM), additive models (GAM), Bayesian kernel...
// Di Xiao 1, * , Weihuang Huang Meiling Ou 1 Congcong Guo Xingguang Ye Yang Liu Man Wang Baohuan Zhang Na Shiqi Jiankun Zang 5 Zixing Zhou Zihao Wen Chengli Zeng Chenfei Wu Chuican Xiangcai Wei 4 Guang 2, 3 Chunxia Jing Department of Epidemiology, School Medicine, Jinan University, Guangzhou, Guangdong, China 2 Parasitology, Key Laboratory environmental exposure and health in Family Planning Research Institute Guangdong Province, Pathophysiology, These authors are contibuted equally to this...
Objective The present study aimed to evaluate the effects of cluster differentiation (CD)4 + CD25 forkhead box p3 (Foxp3) regulatory T cells (Tregs) on unexplained recurrent spontaneous abortion (URSA) and associated mechanisms. Methods proportion CD4 Foxp3 Tregs inflammatory cytokine concentrations in peripheral blood women with URSA were measured by flow cytometry enzyme-linked immunosorbent assay, respectively. CBA/JxDBA/2J mating was used establish an abortion-prone mouse model mice...
Purpose This study aimed to investigate the profiles of messenger RNAs (mRNAs) and long noncoding (lncRNAs) in peripheral blood samples collected from polycystic ovary syndrome (PCOS) patients. In addition, an in-depth bioinformatics analysis regarding lncRNA-mRNA co-expression network was performed. Methods High-throughput sequencing used measure mRNAs lncRNAs expressed isolated six patients (three with PCOS three normal women). five differentially were chosen validate results...
A simultaneous and rapid quantification method of the thalassemia screening indicators (MCV, MCH HbA2) in human blood was discussed by using Fourier transform infrared (FTIR) spectrometer attenuated total reflection (ATR) techniques. Eight samples were collected, MCV, HbA2 measured conventional chemical methods respectively, it as reference value calibration model for spectrum. Each sample distilled water hemolysis, diluted to 2 times, 3 4 5 6 times hemolytic solution whole had been together...
Background: The occurrence of cervical cancer is a complex process, for which human papillomavirus (HPV) infection risk factor, although not all women infected with HPV will develop the disease. Knockout mammalian lung metastasis associated transcript 1 (MALAT1) increased several types, whereas long non-coding RNA (lncRNA) THRIL essential induction tumor necrosis factor-α expression, plays important roles in infection. Materials and Methods: To investigate effects polymorphisms lncRNAs...