BackgroundDrug delivery and penetration into neoplastic cells distant from tumor vessels is critical for the effectiveness of solid chemotherapy. We hypothesized that 10- to 20-nm nanoassemblies phospholipids containing doxorubicin would improve drug's penetration, accumulation, antitumor activity.

Colistin is the last-resort antibiotic to treat multidrug-resistant (MDR) Gram-negative bacterial infections that are untreatable by other clinically available antibiotics. However, recently merged plasmid-borne gene mobilized colistin resistance (mcr) leads modification of target (i.e., membrane), greatly compromising therapy outcome colistin. To address this unmet clinical need, a nanocomplex (CMS-pEt_20 NP) anionic prodrug methanesulfonate (CMS) and guanidinium-functionalized cationic...

Antibiotic colistin is the last line of defense against multidrug-resistant (MDR) Gram-negative bacterial infections. Emergence resistance in microbes a critical challenge. Herein, curcumin discovered, for first time, to reverse phenotype colistin-resistant bacteria via checkerboard assay. For co-delivery and colistin, negatively charged poly(ethylene glycol)-functionalized liposomes encapsulating both drugs (Lipo-cc) are prepared. Killing kinetics live/dead assays confirm antibacterial...

We quantitatively analyzed the characteristics of cone-beam computed tomography (CBCT) radiomics in different periods during radiotherapy (RT) and then built a novel nomogram model integrating clinical features dosimetric parameters for predicting radiation pneumonitis (RP) patients with esophageal squamous cell carcinoma (ESCC).At our institute, retrospective study was conducted on 96 ESCC whom we had complete feature parameter data. CBCT images each patient three RT were obtained,...

Abstract Purpose To compare quality of vision and vision‐related life (QOL) in patients undergoing Descemet membrane endothelial keratoplasty (DMEK) or ultrathin stripping automated (DSAEK). Methods Fifty‐four eyes 54 with Fuchs' dystrophy from six corneal clinics the Netherlands were randomized to DMEK DSAEK examined preoperatively, 3, 6 12 months postoperatively. Main outcome measures higher‐order aberrations (HOAs), contrast sensitivity, straylight QOL. Results Posterior HOAs decreased...

The chronic pathological changes in vascular walls of hypertension may exert destructive effects on multiple organ systems. Accumulating evidence indicates that inflammatory reactions are involved the hypertension. Three peroxisome proliferator-activated receptors (PPARs) have been identified: PPARalpha, PPARbeta/delta, and PPARgamma, all which biological effects, especially inhibition inflammation. aim this study was to evaluate PPAR isoforms expression profile important organs...

Cervical cancer (CC) is one of the most common female malignancies over world. Microtubule-associated protein 7 (MAP7) belongs to family microtubule-associated proteins (MAPs) which involve in microtubule dynamics and are critical several important cellular intracellular activities. This study aimed investigate expression potential role MAP7 CC.The level CC tissues normal were analyzed using data obtained from The genomes atlas (TCGA) genotype-tissue (GTEx) databases. prognostic value...

One of the disadvantages in microscope-integrated optical coherence tomography (MI-OCT) systems is that medical images acquired via different modalities are usually displayed independently. Hence, surgeons have to match two-dimensional and three-dimensional same operative region subjectively. In this paper, we propose a simple registration method overcome problem by using guided laser points. This combines augmented reality with an existing MI-OCT system. The basis our idea introduce guiding...

Purpose: To evaluate the potential value of microscope-integrated optical coherence tomography (MI-OCT) in anterior segment surgical maneuvers. Methods: Twenty-four ophthalmology residents, who were randomly and evenly divided into two groups, performed four maneuvers (corneal tunnel, scleral simple corneal suture, laceration repair) on porcine eyes with (group B) or without A) real-time MI-OCT feedback. All residents again MI-OCT. Results: Compared group A, B (with MI-OCT) showed better...

Verticillium wilt caused by soil borne fungus dahliae could significantly reduce cotton yield.The Ve1 homologous gene Gbvdr3 is resistant to wilt.In order understand of the function promoter in Gossypium barbadense, region receptor-like was obtained genome walking, and cis-element identified using PLACE software this study.The sequence analysis showed that contained elements related stress resistance light regulation.The cloned fused GUS reporter transformed into Arabidopsis.GUS expression...

Abstract Background The widespread implementation of computed tomography has significantly increased the detection small pulmonary nodules, including atypical adenomatous hyperplasia, minimally invasive adenocarcinoma (MIA), and (IAC). Few studies have focused on genomic differences between MIA IAC. Methods We retrospectively analyzed patients with lung (LUAD) who underwent surgery from January 2020 to December 2023. Patients were categorized into IAC groups. mutation status common driver...

Under conditions of translation, rotation, pose alteration, jamming and shelter targets, undesired Inverse Synthetic Aperture Radar (ISAR) images will make target classification more difficult. In this paper, an available ISAR recognition method based on the affine invariance strong scattering centers in image is presented. The approach carries out interference suppression at first, then extracts constructs affine-invariance features, finally uses geometric hash as final classifier....

Aiming at technical difficulties in feature extraction for the inverse synthetic aperture radar (ISAR) target recognition, this paper imports concept of visual perception and presents a novel method, which is based on combination non-negative sparse coding (NNSC) linear discrimination optimization, to recognize targets ISAR images. This method implements NNSC matrix constituted by intensities pixels images training, obtain bases characterize distribution strong scattering centers. Then...

Abstract Background: Triclosan (TCS) is an antimicrobial chemical widely used in personal care products. Most of TCS discharged into aquatic ecosystem after usage. While has potential thyroid-disrupting effect, it unknown whether early exposure to affects thyroid grand and hormone levels. We zebrafish model examine this topic. Methods: The fertilized eggs were exposed TCS. inspected hatching mortality larvae. total triiodothyronine (TT 3 ), thyroxine 4 free (FT ) levels measured at 7, 14 120...

The isovolumetric hemodilution treatment reduces ischemic injury and anti-radical interventions may reduce reperfusion injury. However, the effects of with both have never been investigated. In present study, anesthetized rabbits underwent 45 min coronary artery ligation, which was followed by 180 reperfusion. Ten animals in each group received: (i) normal saline only; (ii) Dextran 40 during ischemia; (iii) superoxide dismutase (SOD) 1 before reperfusion; (iv) combined SOD.(1) compared those...

Abstract We describe a distortion correction algorithm for OCT images based on the scalpel. In this algorithm, distorted are segmented into three parts depending seven customized fiducials. Image translation and image stitching used to eliminate majority of distortions. After performing experiments with porcine eyes, we basically correct optical distortions caused by reflection interlayer scattering effects. The error is less than 2%. Our could bring many potential applications in ophthalmic...