A5101642093- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Clostridium difficile and Clostridium perfringens research
- Gastrointestinal motility and disorders
- Gut microbiota and health
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Botulinum Toxin and Related Neurological Disorders
- Animal Virus Infections Studies
- Ion Channels and Receptors
- Neurological Complications and Syndromes
- Autism Spectrum Disorder Research
- Platelet Disorders and Treatments
- Acute Ischemic Stroke Management
- Migraine and Headache Studies
- Atherosclerosis and Cardiovascular Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Protease and Inhibitor Mechanisms
- Vagus Nerve Stimulation Research
- Cardiac Arrest and Resuscitation
- Trauma and Emergency Care Studies
- Calcium signaling and nucleotide metabolism
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological Disease Mechanisms and Treatments
- Stress Responses and Cortisol
University of Nebraska–Lincoln
2024-2025
Songshan Lake Materials Laboratory
2024
Guangdong Medical College
2017-2024
Dongguan People’s Hospital
2024
Jiangsu University
2019
Zhejiang Chinese Medical University
2014
University of Massachusetts Chan Medical School
2005
ABSTRACT Treatment with antibiotics is a major risk factor for Clostridioides difficile infection, likely due to depletion of the gastrointestinal microbiota. Two microbiota-mediated mechanisms thought limit C. colonization include conversion conjugated primary bile salts into secondary toxic growth and competition between microbiota limiting nutrients. Using continuous flow model that simulates nutrient conditions distal colon, we investigated how treatment 6 clinically used influenced...
The seeding amplification assay (SAA) has recently emerged as a valuable tool for detecting α-synuclein (αSyn) aggregates in various clinically accessible biospecimens. Despite its efficiency and specificity, optimal tissue-specific conditions distinguishing Parkinson's disease (PD) from non-PD outside the brain remain underexplored. This study systematically evaluated 150 reaction to identify one with highest discriminatory potential between PD non-synucleinopathy controls using skin...
ABSTRACT The Spike (S) protein of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) plays important roles in viral pathogenesis and potentially development an effective vaccine against this virulent infectious disease. In study, codon-optimized S gene SARS-CoV was synthesized to construct DNA plasmids expressing either full-length or segments protein. High titer S-specific immunoglobulin G antibody responses were elicited rabbits immunized with various Two neutralizing...
Seed amplification assays (SAA) enable the of pathological misfolded proteins, including α-synuclein (αSyn), in both tissue homogenates and body fluids Parkinson's disease (PD) patients. SAA involves repeated cycles shaking or sonication coupled with incubation periods. However, this scheme has limitations tracking protein propagation due to fragmentation.
Treatment with antibiotics is a major risk factor for
Migraine is one of the most common neurological disorders which poses significant socioeconomic burden worldwide. Neuroinflammation and oxidative stress both play important roles in pathogenesis migraine. Human urinary kallidinogenase (UK) a tissue kallikrein derived from human urine. Increasing evidence suggests that UK may protect against ischemic stroke, but UK’s treatment potential migraine remains to be explored. Immortal BV-2 murine microglial cells were treated with (125 nM, 250 500...
Abstract Injecting α‐synuclein pre‐formed fibrils (αSyn PFFs) into various tissues and organs involves converting monomeric αSyn a fibrillar form, inducing extensive pathology that effectively models Parkinson's disease (PD). However, the distinct physicochemical properties of amyloid can potentially reduce their seeding activity, especially during storage. In this study, it is demonstrated PFFs exhibit significant sensitivity to low temperatures, with notable denaturation occurring between...
Objective To analyze the clinical intervention strategy of pre-hospital first aid for coma patients. Methods A total 208 cases emergency patients called from June 2017 to May 2018 in nine hospitals under jurisdiction Zhenjiang were analyzed retrospectively, including 116 males and 92 females, aged 18~98 years [(54.5±8.5) years]. More than females included standard (GCS score 3~14), onset age was concentrated 45~65 old, with 67 (23.93%) cerebrovascular accidents, 45 (21.63%) severe...
This study aimed to examine changes in electrolytes and acid-base status primary secondary hypokalaemic periodic paralysis (HypoPP), which will help early differential diagnosis of HypoPP. A total 64 HypoPP patients were enrolled relevant data from clinical records was collected. Overall, (mean age 28.2±7.3 years) 58(91%) males, with 39, 11 14 patients, respectively, diagnosed as HypoPP, thyrotoxic other HypoPPs at discharge, assessed. Those conditions than hyperthyroidism more likely...